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Levothyroxine

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Identification
Molecular formula
C15H11I4NO4
CAS number
51-48-9
IUPAC name
2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-2-methyl-propanoic acid
State
State
Solid at room temperature, typically found in pharmaceutical tablets.
Melting point (Celsius)
234.50
Melting point (Kelvin)
507.70
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
776.87g/mol
Molar mass
776.8700g/mol
Density
1.7000g/cm3
Appearence

Levothyroxine typically appears as a white to off-white crystalline powder. It is odourless and stable under normal conditions, but it exhibits sensitivity to light. This compound may also appear as tablets for pharmaceutical use.

Comment on solubility

Solubility of 2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-2-methyl-propanoic acid

The solubility of 2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-2-methyl-propanoic acid can be influenced by several factors, primarily due to its complex structure. Below are key points regarding its solubility:

  • Polarity: The presence of multiple hydroxyl groups and amino groups suggests that this compound may exhibit significant hydrophilic characteristics, potentially enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The compound can form hydrogen bonds with water molecules, which might assist in dissolving in aqueous solutions.
  • Iodine Atoms: The presence of iodine atoms in the structure could impart certain halogen-related solubility traits, possibly affecting overall solubility in organic solvents compared to water.
  • Acidity: As an acid, it may ionize in solution, increasing its solubility depending on the pH of the medium.

In summary, while the structural components suggest a tendency towards increased solubility in water due to ionic and hydrophilic interactions, the exact solubility can be variable and is influenced by environmental conditions. Factors such as temperature, pH, and the presence of other solutes can markedly alter its solubility behavior.

Interesting facts

Interesting Facts about 2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-2-methyl-propanoic acid

This compound, often abbreviated in scientific discussions, retails a unique structure that is of considerable interest in the fields of medicinal chemistry and biochemistry. Here are some intriguing aspects:

  • Pharmaceutical Potential: The presence of iodine and hydroxyl groups in its structure suggests potential applications in developing pharmaceuticals, particularly in targeting specific biological pathways.
  • Structural Complexity: Its intricate molecular architecture can serve as a fascinating study in stereochemistry and molecular interactions. The multiple iodine substituents can impact the compound's reactivity and interactions with biological molecules.
  • Bioactivity Studies: Several studies have investigated compounds similar to this one for their bioactivity, including antibacterial and antiviral properties, due to the presence of iodo and phenyl groups.
  • Analytical Challenges: The complexity of the molecule may present unique challenges in terms of synthesis and characterization, making it an excellent case study for advanced organic chemistry techniques.
  • Interdisciplinary Implications: This compound can bridge various disciplines such as organic chemistry, pharmacology, and environmental science, particularly concerning iodine’s role in human health and the ecosystem.

Overall, 2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-2-methyl-propanoic acid serves as an excellent compound for experimental and theoretical exploration, opening avenues for research and application in several scientific domains.