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Melphalan

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Identification
Molecular formula
C13H18Cl2N2O2
CAS number
148-82-3
IUPAC name
2-amino-3-[4-[bis(2-chloroethyl)aminomethyl]phenyl]propanoic acid
State
State

Melphalan is a solid at room temperature.

Melting point (Celsius)
89.00
Melting point (Kelvin)
362.15
Boiling point (Celsius)
283.00
Boiling point (Kelvin)
556.15
General information
Molecular weight
305.20g/mol
Molar mass
305.1980g/mol
Density
1.2672g/cm3
Appearence

Melphalan is typically a white to off-white crystalline powder. It may appear as fine, odorless crystals.

Comment on solubility

Solubility of 2-amino-3-[4-[bis(2-chloroethyl)aminomethyl]phenyl]propanoic acid

When discussing the solubility of 2-amino-3-[4-[bis(2-chloroethyl)aminomethyl]phenyl]propanoic acid, it is essential to consider several factors that influence its behavior in different solvents.

Factors Affecting Solubility

  • Polarity: The presence of both amino and carboxylic acid functional groups contributes to its polar nature, enhancing solubility in polar solvents.
  • Hydrogen Bonding: This compound can engage in hydrogen bonding, which generally increases solubility in water and alcohols.
  • Solvent Interactions: The specific interactions between solvent molecules and the compound can vary greatly, making some solvents more favorable than others.

Expected Behavior

In general, one can expect:

  • Good solubility in water due to polar interactions.
  • Potentially moderate solubility in organic solvents, depending on their polarity.
  • Limited solubility in non-polar solvents due to the overall polar structure.

It's important to keep in mind that the actual solubility may be influenced by factors such as temperature, pH, and the presence of other solutes.
As always, empirical testing should be conducted to ascertain precise solubility characteristics in various environments.

Interesting facts

Interesting Facts about 2-amino-3-[4-[bis(2-chloroethyl)aminomethyl]phenyl]propanoic acid

2-amino-3-[4-[bis(2-chloroethyl)aminomethyl]phenyl]propanoic acid, often referred to in scientific literature by its abbreviation or as an active pharmaceutical ingredient (API), presents a fascinating case in the field of medicinal chemistry. Here are some noteworthy insights:

  • Dual Functionality: This compound's structure features both an amino acid and a functional group that can interact with biological molecules, highlighting its potential as a drug candidate in treating various diseases.
  • Mechanism of Action: Compounds like this one are often designed to mimic natural processes in the body, suggesting potential pathways for therapeutic effects against specific conditions, particularly in oncology.
  • Chloroethyl Group: The presence of bis(2-chloroethyl) groups implies that this compound may possess alkylating properties, which allows it to chemically modify other molecules, an aspect that can be particularly useful in targeting cancer cells.
  • Importance in Drug Development: Compounds with similar structural features are often subjected to extensive study in drug development programs due to their unique interactions with protein targets and the possible reduction of side effects.
  • Synthetic Routes: The synthesis of this compound can be quite intricate, involving multiple steps of organic reactions which provide insights into the methodologies employed in creating complex pharmaceuticals.
  • Research Applications: Scientists are continuously exploring derivatives of this compound to enhance efficacy, reduce toxicity, and improve pharmacokinetic properties, making it a subject of considerable research interest.

In summary, 2-amino-3-[4-[bis(2-chloroethyl)aminomethyl]phenyl]propanoic acid stands out not only for its unique structure but also for its potential applications in medicine. The ongoing research in this area reflects the compound’s significance and the dynamic nature of chemical sciences.