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Floxuridine

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Identification
Molecular formula
C9H11FN2O5
CAS number
50-91-9
IUPAC name
2-amino-3-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)propanoic acid
State
State

Solid at room temperature.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.15
Boiling point (Celsius)
533.30
Boiling point (Kelvin)
806.50
General information
Molecular weight
246.19g/mol
Molar mass
246.1820g/mol
Density
2.0925g/cm3
Appearence

Floxuridine appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-amino-3-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)propanoic acid

The compound 2-amino-3-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)propanoic acid, with the chemical formula C9H11FN2O5, exhibits interesting solubility characteristics influenced by its functional groups.

Generally, the solubility of this compound can be summarized as follows:

  • Water Solubility: The presence of polar functional groups, including amino (-NH2) and carboxylic acid (-COOH), often contributes to enhanced solubility in water.
  • Organic Solvents: Due to the hydrophilic nature imparted by these groups, the solubility in organic solvents may vary; it is typically low to moderate depending on the solvent polarity.
  • pH Dependence: The carboxyl group may ionize at higher pH levels, resulting in increased solubility in alkaline conditions as it becomes negatively charged.

As a result, it is reasonable to expect that 2-amino-3-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)propanoic acid would be more soluble in aqueous solutions compared to less polar organic solvents. Overall, the solubility features of this compound underscore the importance of intermolecular interactions, such as hydrogen bonding, that significantly influence how well it can dissolve in various environments.

Interesting facts

Interesting Facts about 2-amino-3-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)propanoic Acid

2-amino-3-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)propanoic acid is a fascinating compound that merges structural complexity with significant biological implications.

Key Characteristics:

  • Amino Acid Connection: This compound serves as a derivative of an amino acid, which highlights its relevance in biological systems, particularly in protein synthesis and biochemical pathways.
  • Fluorine Substitution: The presence of a fluorine atom enhances the compound's bioactivity and can influence its interaction with biological targets, potentially leading to novel therapeutic applications.
  • Pyrimidine Framework: The incorporation of a pyrimidine ring contributes to the compound's ability to mimic nucleobases, thus promoting research in medicinal chemistry, especially in designing antiviral or anticancer agents.

Applications and Research Implications:

This compound's structural features make it a subject of interest in numerous fields:

  • Pharmaceutical Development: Researchers are actively exploring its potential as a lead compound in drug discovery due to its unique pharmacophore.
  • Biochemistry Studies: It may serve as a valuable tool in understanding amino acid metabolism, particularly with its unique substitutions.
  • Research on Fluorinated Compounds: The impacts of fluorine in drug design are extensively studied and this compound is no exception, showcasing how minor modifications can lead to enhanced activity.

Conclusion:

This compound exemplifies the intersection of chemistry and biology, merging organic synthesis with medicinal chemistry. As scientists continue to investigate 2-amino-3-(5-fluoro-2,4-dioxo-pyrimidin-1-yl)propanoic acid, we can expect to uncover further intriguing insights into its mechanisms of action and potential therapeutic benefits.

Synonyms
fluorowillardiine
SCHEMBL3676114
SCHEMBL8296644
DTXSID00861355
2-amino-3-(5-fluoro-2,4-dioxopyrimidin-1-yl)propanoic acid
AKOS013400289
3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)alanine
(alphaS)-alpha-Amino-5-Fluoro-3,4-Dihydro-2,4-Dioxo-1(2H)-Pyrimidinepropanoicacid