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Leucine

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Identification
Molecular formula
C6H13NO2
CAS number
61-90-5
IUPAC name
2-amino-4-methyl-pentanoic acid
State
State

At room temperature, leucine is typically in a solid state, appearing as a white crystalline powder.

Melting point (Celsius)
293.00
Melting point (Kelvin)
566.15
Boiling point (Celsius)
245.00
Boiling point (Kelvin)
518.15
General information
Molecular weight
131.18g/mol
Molar mass
131.1750g/mol
Density
1.2930g/cm3
Appearence

Leucine appears as a white crystalline powder.

Comment on solubility

Solubility of 2-amino-4-methyl-pentanoic acid (C6H13NO2)

2-amino-4-methyl-pentanoic acid, commonly known as a form of amino acid, exhibits notable solubility properties that are essential to its functionality.

Key Points about Solubility:

  • Water Solubility: It is generally considered to be soluble in water due to its ability to form hydrogen bonds, which is a characteristic feature of amino acids.
  • pH Sensitivity: The solubility can vary significantly with pH, especially due to the ionizable nature of its amino (–NH2) and carboxyl (–COOH) functional groups. At physiological pH (around 7.4), it tends to exist in its ionic form, enhancing solubility.
  • Solvent Interactions: While water is the primary solvent, 2-amino-4-methyl-pentanoic acid may show differing solubility in organic solvents, generally being less soluble in non-polar solvents.

In summary, 2-amino-4-methyl-pentanoic acid's solubility is a pivotal aspect of its chemical reactivity and biological interactions, governed primarily by its ionic nature and the surrounding solvent conditions. Understanding this property is essential for applications in biological systems and pharmaceuticals.

Interesting facts

Exploring 2-Amino-4-methyl-pentanoic Acid

2-amino-4-methyl-pentanoic acid, also known as leucine in the context of amino acids, is one of the essential building blocks of protein. This compound is classified as one of the branched-chain amino acids (BCAAs) and plays a pivotal role in various biological processes.

Key Characteristics and Functions

  • Protein Synthesis: Leucine is crucial for the synthesis of proteins in the body, particularly in muscle tissue recovery and growth.
  • Energy Production: It can be converted into glucose via gluconeogenesis, providing an energy source when carbohydrates are scarce.
  • Regulation of Metabolism: This amino acid has been shown to stimulate muscle protein synthesis by activating the mTOR pathway, which is essential for cell growth and metabolism.
  • Critical for Athletes: Leucine supplementation is popular among athletes and bodybuilders to enhance muscle recovery and performance.

Interesting Fact

Despite being just one of many amino acids, leucine’s unique structure, which includes a branched-chain configuration, makes it particularly effective in promoting muscle growth. In fact, it is often referred to as the "king of amino acids" due to its significant influence on muscle building.

Applications in Nutrition

Leucine is included in various dietary supplements, especially those aimed at enhancing exercise performance. It can be found in:

  • Protein Powders: Used by fitness enthusiasts to boost protein intake.
  • Meal Replacement Shakes: To ensure adequate nutritional supply for muscle repair.
  • BCAA Supplements: Often marketed specifically for muscle recovery and performance enhancement.

Overall, 2-amino-4-methyl-pentanoic acid represents a vital component of nutrition and metabolism, supporting muscle health and overall physiological function. Its role in both fundamental biology and applied sports science illustrates the intersection of biochemistry and practical health applications.

Synonyms
DL-Leucine
328-39-2
H-DL-Leu-OH
2-Amino-4-methylpentanoic acid
Leucine, DL-
(RS)-Leucine
25322-63-8
(+-)-Leucine
MFCD00063087
1QSS9D5DR6
DL-LEUCINE (15N)
( inverted exclamation markA)-Leucine
2-amino-4-methyl-pentanoic acid
NSC 9252
NSC-9252
NSC46709
EINECS 206-328-2
DL-LEUCINE [FCC]
AI3-26709
73579-45-0
CHEBI:25017
DTXSID00859050
(+/-)-Amino-4-methylpentanoic acid
Leuzin
DL-LEUCINE-4,5,5,5,6,6,6-D7
Hleu
Norvaline, 4-methyl-
L-Leucine, Non-animal origin
UNII-1QSS9D5DR6
NSC9252
L-Leucine (18O2, 94%)
Pentanoic acid, 2-amino-4-methyl-
d,l-leucine
3h-leucine
DL Leucine
d,1-leucine
Leucine #
.alpha.-Amino-.gamma.-methylvaleric acid
L(+)-Leucine
(.+-.)-Leucine
(.+/-.)-Leucine
Leu247
LEUCINE,(L)
SCHEMBL3888
.alpha.-Aminoisocaproic acid
2-amino-4-methylpentanoicacid
CHEMBL46575
WLN: QVYZ1Y1&1 -L
2-amino-4-methyl pentanoic acid
DTXCID60206122
WLN: QVYZ1Y1 & 1-D
Valeric acid, 2-amino-4-methyl-
DL-Leucine, >=99% (HPLC)
HY-B1674
NSC77687
AC7886
LMFA01100048
STL281857
AKOS000118923
AKOS016050505
CS-W020700
FL28874
PB47827
AC-24099
AS-12287
DA-65019
NCI60_004103
SY005863
SY006365
SY033229
DB-048277
DB-048278
DB-056575
DL-Leucine, Vetec(TM) reagent grade, 99%
L0028
NS00013838
(+/-)-2-AMINO-4-METHYLVALERIC ACID
EN300-18048
A817787
SR-01000944477
SR-01000944477-1
Q60662890
Z57127546
F2191-0181
8EB2668C-D303-4401-A7D5-8ABD6B79B75F
L-Leucine, from non animal origin,suitable for cell culture
206-328-2
25988-64-1