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Coenzyme B12

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Identification
Molecular formula
C72H100CoN18O17P
CAS number
13870-90-1
IUPAC name
[[2-amino-4-oxo-6,7-bis(sulfanyl)-1,5,5a,8,9a,10-hexahydropyrano[3,2-g]pteridin-8-yl]methoxy-hydroxy-phosphoryl] [5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
State
State

At room temperature, Coenzyme B12 is typically found as a solid. It is sensitive to air and light, requiring careful storage to maintain its stability.

Melting point (Celsius)
300.00
Melting point (Kelvin)
573.00
Boiling point (Celsius)
100.00
Boiling point (Kelvin)
373.00
General information
Molecular weight
1579.60g/mol
Molar mass
1 579.5950g/mol
Density
1.2500g/cm3
Appearence

Coenzyme B12, also known as adenosylcobalamin, typically appears as dark red crystals or powder. It is sensitive to light and can degrade if exposed for prolonged periods.

Comment on solubility

Solubility of the Compound

The solubility of the compound, C72H100CoN18O17P, can be quite complex due to its intricate structure and multiple functional groups. Generally speaking, the solubility of a compound is influenced by several factors:

  • Polarity: The presence of hydroxyl (-OH) and phosphate (-PO4) groups suggests that the compound may exhibit considerable polarity, likely contributing to its solubility in polar solvents, such as water.
  • Sulfanyl Groups: The bis(sulfanyl) moieties can enhance solubility, potentially enabling interactions with water molecules due to the ability to form hydrogen bonds.
  • Hydrophobic Regions: Despite the polar functional groups, the overall large hydrophobic hydrocarbon backbone can hinder solubility in highly polar solvents; therefore, it may show variable solubility depending on the solvent system.

As a result, one might say that this compound is likely to show:

  • Good solubility in: polar solvents like methanol or ethanol.
  • Poor solubility in: non-polar solvents due to the substantial hydrophobic character.

In conclusion, predicting the solubility of this compound necessitates a thorough examination of its interactions with solvents, and experimental testing may be required for precise quantification of its solubility characteristics.

Interesting facts

Interesting Facts about the Compound

This compound, with its intricate structure and diverse functionalities, represents a fascinating example of how complexity in chemical design can lead to significant biological applications.

Key Features:

  • Dual Functionality: This compound possesses both amino and phosphoryl groups, allowing it to engage in a variety of biochemical interactions. Such features can enhance its role in cellular signaling or as a building block in medicinal chemistry.
  • Structural Uniqueness: Its hexahydropyrano[3,2-g]pteridin framework is notable for its potential in pharmaceutical applications, as many bioactive compounds feature similar bicyclic arrangements that can interact with biological targets.
  • Potential Uses: Due to the presence of purine derivatives and phosphoryl groups, this compound can be explored for its roles in nucleotide metabolism and could potentially serve as a therapeutic agent in metabolic disorders or cancer.

As chemists delve deeper into the synthesis and exploration of such complex molecules, they often find themselves at the frontier of novel drug discovery. A quote that resonates here is, “Creativity in design leads to innovation in application.” This compound embodies that principle, showcasing the intricate relationship between structure and function.

Future Implications:

Ongoing research into compounds like this emphasizes the role of interdisciplinary approaches in chemistry, biology, and medicine. The use of phosphorothioate modifications, as present in this structure, can lead to enhanced stability and bioactivity, making them prime candidates for therapeutic exploration.

In conclusion, the intricate nature of this compound is not just a testament to the beauty of chemical science but a reflection of the potential each molecule holds in unraveling solutions to pressing health challenges.