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Monochloroacetanilide

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Identification
Molecular formula
C13H9Cl2NO
CAS number
86-98-6
IUPAC name
(2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone
State
State

At room temperature, (2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone is in a solid state.

Melting point (Celsius)
73.00
Melting point (Kelvin)
346.00
Boiling point (Celsius)
443.70
Boiling point (Kelvin)
716.90
General information
Molecular weight
267.12g/mol
Molar mass
267.1170g/mol
Density
1.4043g/cm3
Appearence

(2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone typically appears as a white to light yellow crystalline solid.

Comment on solubility

Solubility of (2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone

The solubility of the compound (2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone can be influenced by various factors including its molecular structure and intermolecular interactions. Generally, the presence of both amino and chloro groups in the molecular structure can affect solubility in polar and nonpolar solvents differently.

Key Considerations for Solubility:

  • Polarity: The amino group (-NH2) contributes to the compound's ability to engage in hydrogen bonding, which typically enhances solubility in polar solvents such as water.
  • Hydrophobic Character: The presence of chlorinated phenyl groups may introduce hydrophobic characteristics, reducing solubility in aqueous environments.
  • Solvent Affinity: Solubility may vary significantly depending on the solvent used, with an increased likelihood of solubility in organic solvents due to the aromatic nature of the structure.

It is often observed that "like dissolves like," meaning polar compounds tend to dissolve well in polar solvents, while nonpolar compounds favor nonpolar solvents. Thus, this compound may exhibit variable solubility profiles depending on the solvent context.

Experimental determination is advisable to accurately gauge the solubility properties of this compound as it may demonstrate unique interactions that influence its behavior in solution.

Interesting facts

Interesting Facts about (2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone

(2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone is a fascinating chemical compound that has captured the interest of researchers and chemists alike due to its unique structure and potential applications. Here are some intriguing facts about this compound:

  • Versatile Intermediate: This compound serves as a valuable intermediate in the synthesis of various pharmaceuticals, particularly in the development of anti-cancer drugs.
  • Biological Activity: The presence of amino and chloro groups in its molecular structure contributes to its biological activity, making it a subject of study in medicinal chemistry.
  • Research Potential: Studies have shown that derivatives of this compound may exhibit properties such as anti-inflammatory and antimicrobial activities, raising interest in its potential therapeutic uses.
  • Structure-Activity Relationship (SAR): Chemists often investigate how modifications in the structure of such compounds influence their biological activities, paving the way for the design of more effective medications.
  • Analytical Techniques: Techniques such as NMR and mass spectrometry play a crucial role in characterizing this compound, allowing chemists to determine its purity and structural integrity.

In summary, (2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone represents a compound with significant relevance in medicinal chemistry, owing to its potential biological activities and versatile applications. As research continues, it may very well contribute to groundbreaking discoveries in therapeutic development.

Synonyms
2-Amino-2',5-dichlorobenzophenone
2958-36-3
(2-Amino-5-chlorophenyl)(2-chlorophenyl)methanone
Methanone, (2-amino-5-chlorophenyl)(2-chlorophenyl)-
Adb, benzophenone
EINECS 220-985-2
G806VEO3KE
BRN 0652774
BENZOPHENONE, 2-AMINO-2',5-DICHLORO-
NSC-611905
DTXSID7062742
LORAZEPAM IMPURITY A [EP IMPURITY]
2,5'-DICHLORO-2'-AMINOBENZOPHENONE
LORAZEPAM IMPURITY A (EP IMPURITY)
DTXCID7038020
220-985-2
(2-amino-5-chlorophenyl)-(2-chlorophenyl)methanone
2-amino-5-chloro-2'-chlorobenzophenone
4-chloro-2-(2-chlorobenzoyl)aniline
2-Amino-5,2'-dichlorobenzophenone
MFCD00007840
(2-Amino-5-chlorophenyl)(2-chlorophenyl)methanone (2-Amino-2',5-dichlorobenzophenone)
UNII-G806VEO3KE
NSC611905
Cambridge id 6738138
Oprea1_589897
MLS000665105
SCHEMBL333313
CHEMBL1488083
KWZYIAJRFJVQDO-UHFFFAOYSA-
2-Amino-2 inverted exclamation mark ,5-dichlorobenzophenone
HMS2564H04
STR05137
2-Amino-5,2'-dichlor-benzophenone
2-amino-2', 5-dichlorobenzophenone
STK108874
AKOS000120909
CS-W010122
FA17439
HY-W009406
PS-7318
NCGC00245639-01
AC-10281
SMR000270335
SY018433
2-Amino-2',5-dichlorobenzophenone, 99%
DB-020371
A1128
NS00028728
EN300-20662
F11228
AB00117816-01
SR-01000242277
(2-amino-5-chlorophenyl) (2-chlorophenyl)methanone
SR-01000242277-1
(2-Amino-5-chlorophenyl)(2-chlorophenyl)methanone #
Q27278905
Z104479678
(2-Amino-5-chlorophenyl)(2-chlorophenyl)-methanone;Lorazepam IMP A;2',5-Dichloro-2-aminobenzophenone
InChI=1/C13H9Cl2NO/c14-8-5-6-12(16)10(7-8)13(17)9-3-1-2-4-11(9)15/h1-7H,16H2