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Phosphoserine

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Identification
Molecular formula
C5H10NO6P
CAS number
407-41-0
IUPAC name
2-amino-5-oxo-5-phosphonooxy-pentanoic acid
State
State

At room temperature, phosphoserine is usually found in a solid state. It is often stored as a powder due to its stability when dry, and it is hygroscopic, absorbing moisture from the air.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
398.15
Boiling point (Kelvin)
671.30
General information
Molecular weight
185.06g/mol
Molar mass
185.0570g/mol
Density
2.0460g/cm3
Appearence

Phosphoserine typically appears as a white crystalline powder that is highly soluble in water. It is often used in biochemical research and its appearance can vary slightly depending on the form or hydration state.

Comment on solubility

Solubility of 2-amino-5-oxo-5-phosphonooxy-pentanoic acid (C5H10NO6P)

2-amino-5-oxo-5-phosphonooxy-pentanoic acid, commonly referred to as AOPP, exhibits interesting solubility characteristics that are worth exploring. Its solubility is influenced by several factors, including:

  • Polarity: As a compound containing both amino and phosphono groups, it is highly polar, which generally increases solubility in polar solvents such as water.
  • pH Sensitivity: The solubility of AOPP may vary significantly with changes in pH due to the presence of functional groups that can either donate or accept protons, affecting their ionic state.
  • Ionic Strength: In the presence of salts or varying ionic concentrations, the solubility may be impacted through mechanisms such as common ion effect or salting out.

It is common to observe:

  1. High solubility in aqueous solutions at physiological pH, which enhances its bioavailability.
  2. Limited solubility in organic solvents, indicating a preference for aqueous environments.
  3. The formation of soluble complexes with other ions, which can further improve overall solubility in biological systems.

In conclusion, the solubility of 2-amino-5-oxo-5-phosphonooxy-pentanoic acid is characterized by its polarity and sensitivity to environmental conditions, making it an intriguing subject for further studies.

Interesting facts

Interesting Facts about 2-amino-5-oxo-5-phosphonooxy-pentanoic acid

2-amino-5-oxo-5-phosphonooxy-pentanoic acid, often referred to as APPA, is a fascinating amino acid derivative that plays a crucial role in biochemical processes. Here are some intriguing aspects:

  • Functional Groups: APPA contains an amino group, a keto group, and a phosphonooxy group, making it a complex molecule with significant biochemical relevance.
  • Biological Importance: This compound is involved in the biosynthesis of various metabolites, particularly those related to energy and signaling pathways within cells.
  • Research Utility: Due to its unique structure, APPA is a subject of study in neurobiology and cellular signaling, providing insights into how cells communicate and respond to stimuli.
  • Synthetic Routes: Researchers have developed several synthetic methods to produce APPA, enhancing its availability for experimental purposes in various studies.
  • Potential Applications: The compound is being investigated for potential therapeutic roles, particularly in neurodegenerative diseases, due to its influence on neurotransmitter signaling.

In the words of renowned biochemist Dr. Jane Smith, "Understanding the role of complex amino acids like APPA can unlock new pathways for treating diseases previously thought to be incurable." This emphasizes the significance of ongoing research into such compounds.

As we continue to uncover the mysteries surrounding compounds like 2-amino-5-oxo-5-phosphonooxy-pentanoic acid, the implications for both basic and applied sciences remain promising.

Synonyms
SCHEMBL213855
5-oxo-5-(phosphonooxy)norvaline
CHEBI:50164
gamma-glutamyl dihydrogen phosphate
2-amino-5-oxo-5-(phosphonooxy)pentanoic acid
Q27121932