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Guanosine

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Identification
Molecular formula
C10H13N5O5
CAS number
118-00-3
IUPAC name
2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
State
State

At room temperature, guanosine is in a solid state. It is stable and does not readily sublimate or vaporize in typical ambient conditions.

Melting point (Celsius)
231.00
Melting point (Kelvin)
504.15
Boiling point (Celsius)
820.00
Boiling point (Kelvin)
1 093.15
General information
Molecular weight
283.24g/mol
Molar mass
283.2410g/mol
Density
2.1500g/cm3
Appearence

Guanosine is typically a white crystalline powder. It is known for its purity and consistent crystalline texture, which is representative of many nucleosides. The compound does not have any distinctive odor and appears colorless in solution.

Comment on solubility

Solubility of 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

The solubility of 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one can vary significantly based on several factors, including temperature, pH, and the presence of solvents. Generally, its solubility characteristics can be summarized as follows:

  • Polar Solvents: This compound exhibits good solubility in polar solvents such as water and methanol, largely due to its multiple hydroxyl groups that facilitate hydrogen bonding.
  • Non-Polar Solvents: Conversely, its solubility in non-polar solvents tends to be quite low, which is typical for compounds containing numerous polar functional groups.
  • Temperature Effects: Increased temperature may enhance solubility to some extent, especially in aqueous solutions.
  • pH Dependence: Changes in pH can impact protonation states, potentially altering solubility. The compound could become more soluble in lower pH environments.

In conclusion, the solubility of this compound is predominantly influenced by its structure and environmental conditions. This allows it to have distinct interactions in different media. As always, for specific applications, it is advisable to conduct experimental solubility tests to determine optimal conditions.

Interesting facts

Exploring 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

This fascinating compound, known commonly in the scientific community, is an important nucleoside derivative that plays a critical role in biochemistry. Here are some intriguing aspects:

  • Biological Significance: This compound is closely related to ribonucleosides and has implications in cellular metabolism and genetic information storage.
  • Structural Features: The tetrahydrofuran moiety within the structure contributes to its unique spatial arrangement, influencing its biological activity.
  • Functionality: As a part of nucleic acids, the compound is involved in the synthesis of RNA and DNA, playing a crucial role in protein synthesis.
  • Interaction with Enzymes: This compound may interact with various enzymes, making it a point of interest for researchers aiming to understand metabolic pathways.
  • Potential Therapeutic Applications: Given its structural characteristics, scientists are investigating its potential as a therapeutic agent in treating viral infections and certain cancers.

As one of the building blocks of life, 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one epitomizes the intersection of chemistry and biology, showcasing the complexity and elegance of molecular interactions in living organisms.

As chemistry students and researchers explore this compound further, they are bound to uncover even more mysteries behind its vital role in biological processes. Remember, “Every compound tells a story, and this one is woven intricately into the fabric of life.”