Guanosine | Solubility of Things

Identification

Molecular formula

C₁₀H₁₃N₅O₅

CAS number

118-00-3

IUPAC name

2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

State

At room temperature, guanosine is in a solid state, typically as a crystalline powder.

Melting point (Celsius)

228.00

Melting point (Kelvin)

501.15

Boiling point (Celsius)

806.00

Boiling point (Kelvin)

1 079.15

General information

Molecular weight

283.27g/mol

Molar mass

283.2680g/mol

Density

2.1700g/cm³

Appearence

Guanosine typically appears as a white crystalline powder. It is relatively soluble in water but sparingly soluble in alcohol.

Comment on solubility

Solubility of 2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

The solubility of 2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one, with the chemical formula C₁₀H₁₃N₅O₅, is influenced by several factors related to its chemical structure. Understanding its solubility can be crucial for applications in pharmaceuticals and biochemistry.

Factors Influencing Solubility:

Polarity: The presence of multiple hydroxyl groups (–OH) in the compound enhances its polarity, typically leading to increased solubility in polar solvents such as water.
Hydrogen Bonding: The ability of the molecule to form hydrogen bonds with solvent molecules contributes significantly to its solubility. Compounds capable of extensive hydrogen bonding generally dissolve better in water.
Molecular Size: Larger molecules may exhibit reduced solubility due to steric hindrance which can hinder interactions with solvents.

It is often observed that:

Highly polar compounds tend to be more soluble in water.
Compounds with significant hydrogen-bonding capabilities have improved solubility.
Molecular structure plays a vital role in determining how well a compound will dissolve.

In conclusion, the solubility of this compound can be categorized as potentially high in polar solvents, particularly due to its numerous hydroxyl functional groups. However, specific conditions such as temperature and pH may further affect its behavior in solution.

Interesting facts

Exploring 2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one is a fascinating compound that falls within the realm of purines, which are essential building blocks in biochemistry. This compound not only has structural significance but also plays pivotal roles in various biological processes.

Key Features

Biosynthesis Insight: The presence of the purine base suggests its involvement in nucleotide metabolism, which is crucial for cellular processes such as DNA and RNA synthesis.
Functional Groups: The hydroxymethyl and hydroxy groups on the tetrahydrofuran moiety highlight its potential to participate in hydrogen bonding, impacting its reactivity and interaction with other biomolecules.
Amino Group Impact: The amino group can be a site for protonation, affecting how this compound behaves in physiological conditions.

Interesting Applications

This compound holds promise in various fields, including:

Drug Design: Due to its structural characteristics, it can serve as a lead compound in the development of new pharmaceuticals targeting purine metabolism disorders.
Biochemical Research: Its unique structure allows for probing into cellular mechanisms and can facilitate the study of enzyme activity related to nucleic acids.

Quote to Ponder

As renowned chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas." This highlights the potential of compounds like 2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one in stimulating innovative thoughts in chemical research.

Through such intriguing structural attributes and possible applications, 2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one stands out as a compound worth exploring further in the context of molecular biology and medicinal chemistry.