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Guanosine

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Identification
Molecular formula
C10H13N5O5
CAS number
118-00-3
IUPAC name
2-amino-9-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
State
State
At room temperature, guanosine is typically a solid. It is stable under ordinary conditions and does not easily vaporize from the solid state.
Melting point (Celsius)
239.00
Melting point (Kelvin)
512.00
Boiling point (Celsius)
645.00
Boiling point (Kelvin)
918.00
General information
Molecular weight
283.24g/mol
Molar mass
283.2410g/mol
Density
2.0200g/cm3
Appearence
Guanosine typically appears as a white to off-white crystalline powder.

It may also appear in the form of colorless crystals. This compound is hygroscopic, absorbing moisture from the air.

Comment on solubility

Solubility of 2-amino-9-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

The solubility of 2-amino-9-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one is influenced by several factors, owing to its complex structure and functional groups. This compound contains both amino and hydroxyl groups, which often enhance solubility in polar solvents such as water. The presence of the hydroxymethyl substituent also contributes to the potential for hydrogen bonding with solvent molecules.

Consider the following key points regarding its solubility:

  • Polarity: The compound’s molecular structure suggests that it is relatively polar, which would likely facilitate its solubility in polar solvents.
  • Hydrogen Bonding: The ability to form multiple hydrogen bonds can increase interactions with water, potentially boosting solubility.
  • Temperature: In general, increased temperature can enhance solubility, especially for organic compounds.
  • pH Influence: The solubility may vary with changes in pH, as ionization of amino groups can alter the compound's charge and solubility profile.

In summary, while it is reasonable to expect that 2-amino-9-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one is soluble in polar solvents due to its structural features and potential for hydrogen bonding, the exact solubility might still require empirical investigation to ascertain specific conditions under which optimal solubility is achieved.

Interesting facts

Interesting Facts about 2-amino-9-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one

This intriguing compound, often referred to as a purine derivative, is notable for its role in various biological processes. The complex structure features a tetrahydrofuran backbone, which contributes to its unique functionality within biochemical pathways.

Key Characteristics:

  • Biological Activity: This compound is involved in the synthesis of nucleotides, which are essential for DNA and RNA synthesis. Nucleotides are the building blocks of genetic material.
  • Potential Therapeutic Applications: Its unique structure allows it to interact with enzymes, making it a candidate for drug development in managing genetic disorders and certain cancers.
  • Stereochemistry: The (4S,5R) configuration indicates a specific arrangement of atoms that crucially influences its biochemical interactions, a prime example of how chirality can play a significant role in medicinal chemistry.

As a researcher or chemistry student, you may find it fascinating that such complex molecules can exhibit profound effects on biological systems. The interplay between structure and function is a critical theme in organic chemistry. As noted by renowned chemist Linus Pauling, "The interface between mathematics and chemistry is a fertile field of exploration." This compound exemplifies that idea perfectly as it straddles the line between simple organic chemistry and intricate biological systems.

Moreover, ongoing studies are continuously unveiling new properties and potential applications of this compound in fields such as pharmacology and biochemistry, highlighting the importance of compounds like this in advancing scientific knowledge and therapeutic options.