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Kanamycin A

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Identification
Molecular formula
C18H36N4O11
CAS number
59-01-8
IUPAC name
2-amino-N-[4-amino-3-[3-amino-6-(1-aminoethyl)tetrahydropyran-2-yl]oxy-2,5-dihydroxy-6-methoxy-cyclohexyl]-N-methyl-acetamide
State
State
Kanamycin A is a solid at room temperature. It is commonly provided as a sulfate salt to improve its solubility in water and its stability in storage.
Melting point (Celsius)
268.00
Melting point (Kelvin)
541.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
484.51g/mol
Molar mass
484.5100g/mol
Density
1.4500g/cm3
Appearence

Kanamycin A typically appears as a white to off-white crystalline powder. It is often supplied as a sulfate salt. The powder is hygroscopic and should be stored in a cool, dry place. It may become yellowish upon prolonged exposure to air or light.

Comment on solubility

Solubility of 2-amino-N-[4-amino-3-[3-amino-6-(1-aminoethyl)tetrahydropyran-2-yl]oxy-2,5-dihydroxy-6-methoxy-cyclohexyl]-N-methyl-acetamide

The solubility of the compound with the formula C18H36N4O11, known as 2-amino-N-[4-amino-3-[3-amino-6-(1-aminoethyl)tetrahydropyran-2-yl]oxy-2,5-dihydroxy-6-methoxy-cyclohexyl]-N-methyl-acetamide, can be intriguing due to its complex structure and functional groups. When considering solubility, the following factors are particularly relevant:

  • Polarity: The presence of multiple hydroxyl groups (-OH) and amino groups (-NH2) contributes to the polarity of the molecule, likely enhancing its ability to dissolve in polar solvents like water.
  • Hydrogen Bonding: The compound's ability to form hydrogen bonds can significantly impact its solubility, especially in aqueous solutions.
  • Solvent Compatibility: It may also exhibit varying solubility in organic solvents; for example, while it might dissolve well in methanol or ethanol due to moderate polarity, it may have lower solubility in non-polar solvents like hexane.
  • Temperature Influence: Temperature can play a crucial role in solubility; typically, higher temperatures result in increased solubility for many compounds.

In conclusion, while the compound is expected to show good solubility in polar solvents and limited solubility in non-polar environments, specific experimental data would be needed to quantify its solubility under various conditions. As with many substances, "the solubility is often contingent upon the interactions between the solute and solvent," underscoring the importance of understanding its chemical behavior in different environments.

Interesting facts

Interesting Facts about 2-amino-N-[4-amino-3-[3-amino-6-(1-aminoethyl)tetrahydropyran-2-yl]oxy-2,5-dihydroxy-6-methoxy-cyclohexyl]-N-methyl-acetamide

This compound, with its intricate structure and unique properties, belongs to a class of pharmaceuticals that often serve as templates for drug design. Here are some fascinating insights into its characteristics:

  • Complex Structure: The compound contains multiple functional groups and a rich array of nitrogen atoms, which contribute to its biological activity. This complexity is typical of many bioactive molecules.
  • Medical Relevance: It is closely related to compounds found in therapeutic agents aimed at various conditions. The presence of amino groups suggests potential interactions with biological receptors or enzymes, making it of interest in medicinal chemistry.
  • Versatile Applications: Due to its ability to form hydrogen bonds, this compound could be explored in diverse applications such as drug delivery systems, where it can facilitate cellular uptake and targeted delivery.
  • Research Interest: Scientists are particularly interested in how alterations to components within its structure can influence both its pharmacodynamics and pharmacokinetics. Understanding how the arrangement and presence of certain groups affect activity can lead to more effective treatments.
  • Analytical Techniques: Researchers utilize techniques like NMR spectroscopy, mass spectrometry, and X-ray crystallography to study compounds such as this one. These methods help elucidate the 3D conformation, enhancing our understanding of its functional mechanisms.

In summary, 2-amino-N-[4-amino-3-[3-amino-6-(1-aminoethyl)tetrahydropyran-2-yl]oxy-2,5-dihydroxy-6-methoxy-cyclohexyl]-N-methyl-acetamide exemplifies the complexity and potential inherent in small organic compounds. Its study not only contributes to chemical knowledge but also opens doors for innovations in therapeutic agents.

Synonyms
Fortimicin
KW-1070
SCHEMBL14269845
DTXSID20860688
DB-052792
2-Amino-5-[glycyl(methyl)amino]-3,6-dihydroxy-4-methoxycyclohexyl 2,6-diamino-2,3,4,6,7-pentadeoxyheptopyranoside