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Melphalan

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Identification
Molecular formula
C13H18Cl2N2O2
CAS number
148-82-3
IUPAC name
2-amino-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide
State
State

At room temperature, melphalan is a solid. As a pharmaceutical agent, it may be presented in various formulations, including tablets or powder, depending on its intended medical use.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
305.20g/mol
Molar mass
305.2030g/mol
Density
1.6460g/cm3
Appearence

Melphalan typically appears as a white to off-white crystalline powder. Due to its form and composition, it can also be described as having a faint yellowish tint in certain cases.

Comment on solubility

Solubility of 2-amino-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide

The solubility of 2-amino-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide presents important implications for its applications in various chemical and biological contexts. Understanding its solubility characteristics is crucial, as it influences the compound's behavior in solutions and its efficacy in pharmaceutical formulations.

Key Aspects of Solubility:

  • Solvent Dependence: The solubility of this compound is typically evaluated in polar solvents such as water or methanol. Its complex structure suggests varying solubility rates based on the solvent used.
  • Temperature Effects: Like many compounds, an increase in temperature generally enhances solubility. It is beneficial to conduct solubility assessments at different temperatures to get a comprehensive understanding.
  • pH Influence: The solubility can be significantly impacted by the pH of the solution, particularly because amino groups can gain or lose protons. Thus, examining solubility across a range of pH conditions is vital.
  • Hydrophobic and Hydrophilic Interactions: The presence of both hydrophobic (due to chloroethyl groups) and hydrophilic (amine groups) features in the compound creates a unique balance that affects its overall solubility.

In summary, the solubility of 2-amino-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide cannot be generalized easily. Factors such as solvent choice, temperature, pH, and the structural characteristics play crucial roles in determining how well this compound dissolves. As is often stated in the field, "the devil is in the details," making precise measurements and conditions vital for accurate solubility profiles.

Interesting facts

Interesting Facts about 2-amino-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide

2-amino-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide is a fascinating compound that serves as an important example in the field of medicinal chemistry. Below are some intriguing aspects of this compound:

  • Anticancer Research: This compound is a derivative of the well-known alkylating agent chlorambucil, which has shown efficacy in treating certain types of cancers. Researchers are continually studying its mechanism and potential therapeutic uses in oncology.
  • Mechanism of Action: The compound’s structure allows it to form DNA cross-links, which is crucial to its ability to inhibit cancer cell proliferation. It interacts with cellular processes, making it a target of interest for developing new cancer therapies.
  • Structure-Activity Relationship (SAR): Chemists analyze the compound's various functional groups and their contributions to its biological activity. This study helps in designing more effective analogs while minimizing side effects.
  • Toxicity Concerns: The presence of chlorinated ethyl groups raises concerns regarding its cytotoxicity. Understanding the relationship between structure and toxicity can guide the development of safer derivatives.
  • Research Opportunities: This compound serves as a valuable research template for medicinal chemists aiming to synthesize novel agents with improved selectivity for cancer cells, possibly leading to fewer side effects than existing treatments.

In summary, 2-amino-N-[4-[bis(2-chloroethyl)amino]phenyl]acetamide continues to attract attention for its potential application in cancer treatment and its role as a pivotal compound in ongoing pharmaceutical research. As scientists delve deeper into its properties and interactions, it may pave the way for advancements in targeted cancer therapies.