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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
2-amino-N-[4-(diethylamino)-2-methyl-phenyl]benzamide
State
State

At room temperature, lidocaine is typically found as a solid crystalline powder. It is often formulated into different pharmaceutical forms, such as creams, gels, and injections.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3390g/mol
Density
1.0261g/cm3
Appearence

Lidocaine appears as a white or slightly yellow crystalline powder. It is often odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 2-amino-N-[4-(diethylamino)-2-methyl-phenyl]benzamide

The solubility of 2-amino-N-[4-(diethylamino)-2-methyl-phenyl]benzamide in various solvents is an important characteristic that can dictate its applications and behavior in diverse chemical environments. Understanding its solubility profile can be elucidated through the following points:

  • Polarity: This compound has both polar and non-polar functional groups, affecting its solubility in different solvents.
  • Water Solubility: Generally, this compound is expected to have low water solubility due to its large hydrophobic aromatic moiety.
  • Organic Solvents: It is likely to be more soluble in organic solvents such as ethanol, methanol, and dichloromethane due to its non-polar character.
  • Temperature Effect: Solubility may also increase with temperature; hence, conducting experiments at varying temperatures can provide more insight.
  • pH Sensitivity: Since it contains an amine group, the solubility may change significantly with pH, influencing the compound's ionization state.

In conclusion, the solubility of this compound is influenced by its structural features and the environment in which it is placed. Careful consideration of the solvent choice and conditions is essential for practical applications.

Interesting facts

Interesting Facts about 2-amino-N-[4-(diethylamino)-2-methyl-phenyl]benzamide

The compound 2-amino-N-[4-(diethylamino)-2-methyl-phenyl]benzamide is a fascinating subject of study characterized by its unique chemical structure and potential applications. Here are some engaging insights:

  • Structure: This compound features a benzamide backbone, which is an essential structure in medicinal chemistry. The presence of an amino group and a diethylamino substituent imparts interesting properties and reactivity.
  • Pharmacological Importance: Compounds with similar structural characteristics are often explored for their biological activities. They may manifest functions as:
    • Antidepressants
    • Antitumor agents
    • Antimicrobial properties
  • Synthetic Versatility: The synthetic routes to obtain this compound often involve modification of aromatic amines, which makes synthetic chemists keenly interested in optimizing reactions to improve yield and minimize by-products.
  • Research Potential: Given its structure, researchers are continuously exploring its potential in drug development and material science, particularly in the formation of dyes or polymers.
  • Historical Context: Compounds in the benzamide family have had a long history in the pharmaceutical industry, giving this compound a fascinating legacy in drug discovery.

In summary, 2-amino-N-[4-(diethylamino)-2-methyl-phenyl]benzamide stands as a prime example of how intricate molecular design can lead to promising compounds that may revolutionize medicinal chemistry. Its complexity and potential keep scientists intrigued, as they delve deeper into the world of synthetic organic chemistry.

Synonyms
ATOLIDE
16231-75-7
Atolida
Go 1213
W 5733
2-Amino-N-(4-(diethylamino)-2-methylphenyl)benzamide
OBN5I4B08W
2-amino-N-[4-(diethylamino)-2-methylphenyl]benzamide
Benzamide, 2-amino-N-(4-(diethylamino)-2-methylphenyl)-
2-Amino-4'-(diethylamino)-o-benzotoluidide
GO-1213
W-5733
Go 1213; Goe 1213; W 5733
Atolidum
Atolide [USAN:INN]
UNII-OBN5I4B08W
4'-Diethylamino-2'-methylanthranilanilid
Atolide (USAN/INN)
ATOLIDE [USAN]
ATOLIDE [INN]
SCHEMBL636237
orb1698288
CHEMBL2106015
DTXSID30167357
AKOS022181398
DB-346927
NS00123511
D03007
Q27285557