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GSK-3 Inhibitor VIII

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Identification
Molecular formula
C32H34N8O2
CAS number
667463-62-9
IUPAC name
2-amino-N1,N4-bis[4-(5-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]terephthalamide
State
State

At room temperature, GSK-3 Inhibitor VIII is typically in a solid state. It is stable under normal conditions of use and storage. The compound is primarily used in laboratory research settings.

Melting point (Celsius)
252.50
Melting point (Kelvin)
525.60
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.00
General information
Molecular weight
523.62g/mol
Molar mass
523.6180g/mol
Density
1.2400g/cm3
Appearence

GSK-3 Inhibitor VIII appears as a white to off-white crystalline powder. Its solid state is characterized by a fine texture and uniform appearance, typical of many organic compounds used in research and development.

Comment on solubility

Solubility of 2-amino-N1,N4-bis[4-(5-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]terephthalamide

The solubility of 2-amino-N1,N4-bis[4-(5-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]terephthalamide can be characterized as follows:

  • Solvent Dependence: This compound may exhibit varied solubility depending on the choice of solvent. Common solvents include dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and dichloromethane (DCM).
  • Polarity Effects: Polar solvents might enhance solubility due to the presence of amino and imidazole functional groups that can form hydrogen bonds.
  • Temperature Influence: Increasing temperature generally leads to higher solubility, a common phenomenon for many organic compounds.

It is essential to note that the presence of the imidazole ring can also contribute to hydrophilicity, while the phenyl groups may introduce hydrophobic characteristics. Consequently, this compound may demonstrate:

  • Low to moderate solubility in water, depending on the specific conditions and concentrations.
  • A dual nature of hydrophilic and hydrophobic properties, influencing how it dissolves in mixed solvent systems.

As a result, *“understanding the solubility profile is crucial for applications in drug development and formulation.”* Exploring various conditions can help identify the most effective medium for achieving optimal solubility.

Interesting facts

Interesting Facts about 2-amino-N1,N4-bis[4-(5-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]terephthalamide

This fascinating compound, often recognized for its complex structure, serves as an excellent example of how molecular modifications can lead to diverse functionalities in chemical compounds. Here are some intriguing points about it:

  • Biological Relevance: Compounds like this one have been researched for their potential biological activities, particularly in the field of drug design. The substitution of imidazole rings could enhance interactions with biological targets.
  • Polymeric Applications: The amide linkages in this structure point to its potential usage in creating polyamides, which are critical in materials science for high-performance polymers.
  • Versatile Synthesis: The synthetic pathways to obtain this compound are quite broad, involving various coupling reactions that could be utilized in developing novel materials or pharmaceuticals.
  • Imidazole Functionality: Imidazole rings are known for their role in biologically active molecules, making this compound interesting for medicinal chemistry research.
  • Structural Diversity: The presence of multiple phenyl groups and branched chains increases this compound's structural diversity, allowing for multiple derivatives that can be synthesized by altering the side chains.

In summary, 2-amino-N1,N4-bis[4-(5-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]terephthalamide is not just a compound with a complex name, but also a versatile building block in chemistry that could pave the way for innovative applications across numerous scientific disciplines.

Synonyms
GNF-Pf-5022
2-Amino-4',4''-bis(5-methyl-2-imidazolin-2-yl)terephthalanilide
4607-27-6
NSC 66761
CHEMBL585815
SCHEMBL15788276
BDBM97432
DTXSID70863422
Terephthalanilide, 2-amino-4',4''-bis(5-methyl-2-imidazolin-2-yl)-