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Chloramphenicol

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Identification
Molecular formula
C11H12Cl2N2O5
CAS number
56-75-7
IUPAC name
2-aminoethanol;5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide
State
State

Chloramphenicol is typically found as a solid at room temperature. It is a crystalline powder and remains stable under prescribed storage conditions.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
323.13g/mol
Molar mass
323.1320g/mol
Density
1.6980g/cm3
Appearence

Chloramphenicol is a white to grayish-white, fine crystalline powder or elongated crystals. It is free or practically free from odour and has a slightly bitter taste. As a solid, it appears slightly yellowish when impure.

Comment on solubility

Solubility of 2-aminoethanol; 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide

The solubility of the compound 2-aminoethanol; 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide reflects the interactions between its hydrophilic and hydrophobic components. This compound contains both amino and hydroxyl functional groups, typically leading to increased solubility in polar solvents. Here are some notable aspects of its solubility:

  • Polar Nature: The presence of amino (-NH2) and hydroxyl (-OH) groups enhances hydrogen bonding with water molecules, promoting higher solubility in aqueous environments.
  • Hydrophobic Region: The aromatic rings and chlorinated groups may introduce some hydrophobic characteristics, potentially limiting solubility in purely polar solvents.
  • Solvent Interaction: This compound is likely more soluble in solvents like ethanol or methanol, which can accommodate both polar and slightly non-polar regions effectively.
  • Temperature Dependence: As is common for many compounds, the solubility may increase with temperature, helping disrupt intermolecular forces.

In summary, while this compound is expected to exhibit good solubility in a range of polar solvents, its exact solubility profile would certainly depend on the specific solvent used and environmental conditions. Understanding these characteristics is crucial for applications in fields such as pharmaceuticals, where solubility can influence bioavailability and efficacy.

Interesting facts

Interesting Facts about 2-aminoethanol; 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide

2-aminoethanol, commonly known as ethanolamine, plays a significant role in the field of chemistry due to its unique properties and versatile applications. Here are some fascinating insights into this compound:

  • Dual Functionality: Ethanolamine serves both as an amine and as an alcohol, making it capable of participating in a wide range of chemical reactions. This dual functionality allows it to be a critical building block in organic synthesis.
  • Biological Relevance: Ethanolamine is vital in biological systems as it is involved in the synthesis of phospholipids. These molecules are essential components of cell membranes, contributing to cell structure and fluidity.
  • Surfactant Properties: It is utilized as a surfactant in various industrial applications, especially in detergents, emulsifiers, and personal care products. This ability to reduce surface tension is crucial in enhancing product effectiveness.
  • Applications in Pharmaceuticals: The compound is also found in numerous pharmaceutical formulations, where it aids in the absorption and delivery of active ingredients. Its ability to enhance the solubility of certain drugs is particularly valuable.
  • Safety and Handling: While ethanolamine is useful, safety measures should be emphasized. It can be corrosive and irritating to the skin and eyes, making proper handling protocols essential in laboratory and industrial settings.

5-Chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide

This compound's complex name infers a rich structure and multiple functional groups which increase its potential applications:

  • Pharmacological Potential: Due to its intricate molecular structure, this compound may exhibit interesting pharmacological properties. Compounds with similar structures have been studied for their effects on various biological pathways.
  • Environmentally Relevant: The presence of chlorine and nitro groups suggests that this compound may be relevant in environmental chemistry, particularly regarding persistence in biological systems and potential bioaccumulation.
  • Synthetic Routes: The synthesis of such compounds often involves multi-step processes, highlighting the creativity and planning required in synthetic organic chemistry.
  • Research Interest: Compounds like this are frequently subjects of research, examining their potential as antibacterial or anticancer agents. Their efficacy often promotes exploration into modifying chemical structures for improved activity.

In summary, both 2-aminoethanol and 5-chloro-N-(2-chloro-4-nitro-phenyl)-2-hydroxy-benzamide hold significant importance in chemistry, food, and pharmaceutical industries, showcasing the interconnectedness of chemical research and practical applications. As scientists and students explore these compounds further, their potential to revolutionize various fields continues to grow.

Synonyms
1420-04-8
Niclosamide-olamine
Clonitralid
Niclosamide ethanolamine salt
Bayluscide
CLONITRALIDE
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)
Niclosamide-olamine [ISO]
Niclosamide olamine
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 2-aminoethanol salt
Niclosamide (olamine)
QT8YUD1Z0W
Mollutox
Baylucit
2-aminoethanol;5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Phenasal ethanolamine salt
Caswell No. 314
Molluscicide bayer 73
Bay 73
Bayer 25648
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide - 2-aminoethanol (1:1)
CCRIS 178
HSDB 4045
NCI-C00431
BAY 6076
EINECS 215-811-7
Niclosamide-(2-hydroxyethyl)ammonium
UNII-QT8YUD1Z0W
EPA Pesticide Chemical Code 077401
HL 2448
M 73
UCCMALUSCIDE
5,2'-Dichloro-4'-nitrosalicylanilide, ethanolamine salt
2',5-Dichloro-4'-nitrosalicylanilide, 2-aminoethanol salt
2',5-Dichloro-4'-nitrosalicyloylanilide ethanolamine salt
5,2-Dichloro-4-nitrosalicylic anilide 2-aminoethanol salt
Salicylanilide, 2',5-dichloro-4-nitro-, ethanolamine salt
Ethanolamine salt of 5,2'-dichloro-4'-nitrosalicyclicanilide
Salicylanilide, 2',5-dichloro-4'-nitro-, compd with 2-aminoethanol (1:1)
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compd with 2-aminoethanol
Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd with 2-aminoethanol (1:1)
C15H15Cl2N3O5
SCHEMBL1871351
CHEMBL3794255
DTXSID3020338
HY-B0497C
2-Aminoethanol salt of 2',5-dichloro-4'-nitrosalicyanalide
NICLOSAMIDE-OLAMINE [HSDB]
BAY-6076
AC-646
MFCD01941566
AKOS015914140
AS-10732
Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compound with 2-aminoethanol (1:1)
DA-66085
FC151081
M-73
NICLOSAMIDE ETHANOLAMINE SALT [MI]
CS-0129002
W13429
Niclosamide-olamine 100 microg/mL in Acetonitrile
Q26841012
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide2-aminoethanolsalt
5716-19-8
Niclosamide-olamine; 2',5-Dichloro-4'-nitrosalicyloylanilide ethanolamine salt; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzami de 2-aminoethanol