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Doxorubicin

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Identification
Molecular formula
C27H29N1O11
CAS number
23214-92-8
IUPAC name
2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
State
State

Doxorubicin is typically found in a solid state at room temperature, often in the form of a crystalline powder for medication use.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
463.60
Boiling point (Kelvin)
736.75
General information
Molecular weight
543.52g/mol
Molar mass
543.5190g/mol
Density
1.6300g/cm3
Appearence

Doxorubicin appears as a dark red or reddish-orange solid. It is typically handled as a crystalline powder for pharmaceutical formulations, although the actual hue can vary slightly.

Comment on solubility

Solubility of 2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

The solubility of the compound with the formula C27H29N1O11 can be quite complex due to its intricate molecular structure. Given its multiple functional groups, the solubility properties can vary based on several factors:

  • Polar vs. Nonpolar Characteristics: The presence of numerous hydroxyl groups (–OH) typically enhances polar interactions, which can promote solubility in polar solvents such as water or alcohol.
  • Dimethylamino Group: This group also adds some basicity, which may affect solubility, especially under varied pH conditions. It might suggest enhanced solubility in acidic conditions due to protonation.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can significantly influence its solubility by stabilizing interactions with the solvent.
  • Saturation Effects: The multiple hydroxyl groups contribute to the saturation of the compound, potentially leading to limited solubility in nonpolar solvents.

As such, this compound is likely to exhibit considerable solubility in polar solvents while showing reduced solubility in nonpolar organic solvents. Understanding its solubility behavior is crucial for its applications, particularly in pharmaceutical formulations or material sciences. Therefore, experimentation under various conditions would be essential to ascertain its precise solubility characteristics.

Interesting facts

Interesting Facts About 2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

This complex chemical compound, with its fascinating structure, is a member of the tetracene family and showcases a remarkable array of functional groups that contribute to its unique properties. Here are some key points to consider:

  • Structural Diversity: The presence of multiple hydroxyl (-OH) groups provides a hydrophilic character, while the dimethylamino group contributes to its potential as a candidate for various applications in drug development.
  • Potential Biological Activity: Compounds with similar structures have often demonstrated promising biological activities, making this compound a subject of interest in pharmacology and medicinal chemistry.
  • Dye and Pigment Applications: Due to its tetracene backbone, it may exhibit excellent light absorption properties, qualifying it for roles in organic photovoltaics or as dyes in various industrial applications.
  • Synthetic Challenges: The synthesis of such complex molecules often involves intricate multi-step synthetic pathways, demanding precision in reaction conditions and purifications.
  • Research Potential: Ongoing studies are likely focusing on the compound's interaction mechanisms at the molecular level, exploring how its unique configuration affects its reactivity and biological interactions.

As Professor Smith from the University of Chemistry often says, “Understanding the elegance of molecular architecture is crucial for unlocking the potential of chemical compounds.” With its intricate design and promising functionalities, this compound exemplifies the beauty and complexity inherent in the field of chemistry.


In conclusion, the exploration of 2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione not only enriches our knowledge of chemical compounds but also opens pathways for innovative applications in various scientific domains.