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Duloxetine

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Identification
Molecular formula
C18H19NS
CAS number
116539-59-4
IUPAC name
2-[amino(methyl)amino]-1-phenyl-propan-1-ol
State
State

Duloxetine at room temperature is typically found in a solid state. It is chemically stable and does not oxidize spontaneously when exposed to air.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
487.50
Boiling point (Kelvin)
760.65
General information
Molecular weight
297.42g/mol
Molar mass
13.1450g/mol
Density
1.3560g/cm3
Appearence

Duloxetine is typically a white to slightly brownish white solid powder. It does not have a particularly distinct odour and is generally provided in a crystalline form that is suitable for pharmaceutical formulations.

Comment on solubility

Solubility of 2-[amino(methyl)amino]-1-phenyl-propan-1-ol

The solubility of 2-[amino(methyl)amino]-1-phenyl-propan-1-ol, often referred to as a *phenylpropanolamine derivative*, can be quite intriguing due to its amino group and alcohol functional groups. Here are some key points to consider regarding its solubility:

  • Polar Nature: The presence of the hydroxyl group (-OH) and the amino groups (-NH₂ and -NH-) indicates a high polarity, which typically enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The potential for hydrogen bonding due to these functional groups can facilitate interactions with solvent molecules, further promoting solubility.
  • Low Solubility in Non-Polar Solvents: Conversely, this compound is likely to exhibit poor solubility in non-polar solvents like hexane or benzene, where such polar interactions are minimal.
  • Impact of pH: The solubility may also vary with pH changes, particularly due to the ionizable nature of the amino group, which can either increase or decrease solubility based on protonation states.

In summary, 2-[amino(methyl)amino]-1-phenyl-propan-1-ol exhibits a tendency towards high solubility in polar environments and may have limited solubility in non-polar conditions, making it a compound of interest within pharmaceutical and chemical research.

Interesting facts

Interesting Facts About 2-[amino(methyl)amino]-1-phenyl-propan-1-ol

2-[amino(methyl)amino]-1-phenyl-propan-1-ol, often referred to in the scientific community as an important compound for various applications, showcases unique characteristics that are crucial for both medicinal chemistry and organic synthesis. Here are some compelling facts:

  • Diverse Applications: This compound serves as a vital intermediate in the synthesis of various pharmaceuticals, particularly in the development of analgesics and anti-inflammatory agents.
  • Structure-Activity Relationship: The presence of the amino and phenyl groups significantly influences its biological activity, making it an ideal candidate for studies focused on drug action mechanisms.
  • Research Interest: Due to its complex structure, it has attracted attention in research communities aiming to explore chiral compounds and their effects on drug efficacy. As stated by a leading chemist, "Understanding the interactions of such compounds at a molecular level can lead to breakthroughs in targeted therapies."
  • Chirality: Notably, this compound possesses chiral centers, which complicates its stereochemistry and opens avenues for studying enantiomer-specific effects in biological systems.
  • Pharmacophore Model: In medicinal chemistry, it serves as an exemplary model for designing new pharmacophores, assisting chemists in identifying essential features required for target interactions.

In summary, 2-[amino(methyl)amino]-1-phenyl-propan-1-ol represents a fascinating entity within chemical research, bridging the gap between complex organic synthesis and practical applications in pharmacology. Its intricate design and diverse functionality underscore its significance in the field.


Synonyms
SCHEMBL647926