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Thiotepa

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Identification
Molecular formula
C6H12N3PS
CAS number
52-24-4
IUPAC name
2-(aziridin-1-yl)-N-[[4-[[[2-(aziridin-1-yl)acetyl]amino]methyl]phenyl]methyl]acetamide
State
State
At room temperature, thiotepa is a solid. It is usually handled as a powder and should be stored under conditions that minimize light exposure, as prolonged exposure may lead to decomposition or loss of potency.
Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
428.20
Boiling point (Kelvin)
701.35
General information
Molecular weight
189.24g/mol
Molar mass
189.2370g/mol
Density
1.1400g/cm3
Appearence

Thiotepa is typically encountered as a white crystalline powder. The solid is stable under normal conditions but should be protected from light to prevent degradation.

Comment on solubility

Solubility Characteristics of 2-(aziridin-1-yl)-N-[[4-[[[2-(aziridin-1-yl)acetyl]amino]methyl]phenyl]methyl]acetamide (C6H12N3PS)

The solubility of 2-(aziridin-1-yl)-N-[[4-[[[2-(aziridin-1-yl)acetyl]amino]methyl]phenyl]methyl]acetamide can be influenced by several factors, primarily due to its unique structure featuring aziridine rings and various functional groups. Understanding its solubility is crucial for applications in pharmaceuticals and chemical synthesis.

Key Factors Affecting Solubility:

  • Polarity: The overall polarity of the compound impacts its ability to dissolve in polar or non-polar solvents.
  • Hydrogen Bonding: The presence of amide and amino groups could enhance solubility in polar solvents through hydrogen bonding interactions.
  • Temperature: Solubility often increases with temperature; thus, heating the solvent may improve the dissolution of this compound.
  • pH Levels: The solubility of the compound might also vary in different pH environments, especially if it involves ionizable groups.

In practical terms, one might find that this compound exhibits moderate solubility in organic solvents such as ethanol or methanol, while possibly being less soluble in non-polar solvents like hexane. Always consider solubility testing in various solvents to fully characterize its behavior under different conditions.

As with many specialized compounds, the evaluation of solubility is not merely a matter of "yes" or "no" but a spectrum of behavior.

Interesting facts

Interesting Facts about 2-(aziridin-1-yl)-N-[[4-[[[2-(aziridin-1-yl)acetyl]amino]methyl]phenyl]methyl]acetamide

This intriguing chemical compound showcases the fascinating world of multifunctional derivatives, where complex biochemistry merges with novel drug design. Here are some key points about this compound:

  • Pharmacological Potential: Compounds that contain aziridine rings are often studied for their potential as anticancer agents. The aziridine moiety can form covalent bonds with nucleophiles in biological systems, making such compounds a focus of pharmaceutical research.
  • Structural Complexity: The combination of aziridine and acetamide functional groups in this compound indicates a sophisticated structural framework. The interplay between these elements can lead to diverse biological interactions and affect the compound's properties.
  • Applications: Given its structure, this compound may be explored for applications in drug delivery systems, potentially allowing targeted therapies to be developed. Its design reflects the precision that modern medicinal chemistry strives for.
  • Derivatization: The incorporation of various functional groups, such as the amino and methyl components, may allow for modulation of activity, altering solubility, and absorption rates, ultimately influencing therapeutic outcomes.

In the words of a renowned chemist, “The best synthetic challenges lead to discoveries that shape the future of healthcare.” The continued study of compounds like 2-(aziridin-1-yl)-N-[[4-[[[2-(aziridin-1-yl)acetyl]amino]methyl]phenyl]methyl]acetamide exemplifies this idea as researchers work to unveil their full potential.

As new research emerges, the prospects surrounding this compound's applications and effects will surely broaden our understanding of its role in science and medicine. Stay tuned for more innovative advancements in the field of chemistry!

Synonyms
10328-31-1
N,N'-(p-Phenylenedimethylene)bis(1-aziridineacetamide)
N,N'-Bis(aziridineacetyl)-1,4-xylylenediamine
1-AZIRIDINEACETAMIDE, N,N'-(p-PHENYLENEDIMETHYLENE)BIS-
2-(aziridin-1-yl)-N-[[4-[[[2-(aziridin-1-yl)acetyl]amino]methyl]phenyl]methyl]acetamide
NSC-115615
N,N/'-(p-Phenylenedimethylene)bis(1-aziridineacetamide)
1-Aziridineacetamide, N,N'-(1,4-phenylenebis(methylene))bis-
1-Aziridineacetamide, N,N'-[1,4-phenylenebis(methylene)]bis-
N,4-xylylenediamine
N,N'-Bis-aziridinylacetyl-1,4-xylenediamine
NSC 115615
BRN 1326686
N,N'-(p-Xylylene)bis(2-(1-aziridinyl)acetamide)
Acetamide, N,N'-(p-xylylene)bis(2-(1-aziridinyl)-
NSC115615
T97KDL3JMZ
DTXSID20145740
1-Aziridineacetamide,N'-(p-phenylenedimethylene)bis-
1-Aziridineacetamide,N'-[1,4-phenylenebis(methylene)]bis-