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Thiotepa

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Identification
Molecular formula
C6H12N2OS
CAS number
52-24-4
IUPAC name
2-(aziridin-1-yl)-N-[7-[[2-(aziridin-1-yl)acetyl]amino]heptyl]acetamide
State
State

At room temperature, thiotepa is typically observed in a solid state.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
365.00
Boiling point (Kelvin)
638.15
General information
Molecular weight
189.24g/mol
Molar mass
189.2370g/mol
Density
1.1238g/cm3
Appearence

Thiotepa appears as a white crystalline solid.

Comment on solubility

Solubility Overview

The compound 2-(aziridin-1-yl)-N-[7-[[2-(aziridin-1-yl)acetyl]amino]heptyl]acetamide exhibits unique solubility characteristics that can be influenced by various factors. Understanding its solubility properties is crucial for its applications in different chemical environments.

Key Factors Affecting Solubility

  • Polarity: The presence of aziridine rings and acetamide functional groups typically suggests a degree of polarity, which can enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the amide and acetyl groups may further promote solubility in aqueous solutions.
  • Temperature: As with many compounds, increasing the temperature often increases solubility, as molecules can gain enough energy to overcome intermolecular forces.
  • pH of the Solution: The solubility of this compound may also vary with pH, as ionization of nitrogen atoms in the amide group can occur, influencing solubility dynamics.

General Observations

Based on its structure, one can suggest:

  • This compound is likely to be more soluble in polar solvents.
  • It may show limited solubility in non-polar solvents, given its polar functional groups.

In summary, the solubility of 2-(aziridin-1-yl)-N-[7-[[2-(aziridin-1-yl)acetyl]amino]heptyl]acetamide is influenced by several factors, making it essential to consider these characteristics during practical applications.

Interesting facts

Interesting Facts about 2-(aziridin-1-yl)-N-[7-[[2-(aziridin-1-yl)acetyl]amino]heptyl]acetamide

This compound is part of a fascinating class known as aziridine derivatives, which are recognized for their unique three-membered nitrogen-containing ring structures. These compounds often exhibit a range of biological activities, making them valuable in pharmaceutical research.

Key Features

  • Biological Relevance: Aziridine derivatives are known for their roles in medicinal chemistry, where they can serve as intermediates in the synthesis of more complex molecules.
  • Potential Applications: Due to their unique structural characteristics, these compounds may have potential applications in the development of anti-tumor agents and other therapeutic drugs.
  • Reactivity: The strained nature of the aziridine ring makes these compounds highly reactive. This can enable them to participate in various chemical reactions, which is a subject of interest for organic chemists.

Furthermore, compounds like 2-(aziridin-1-yl)-N-[7-[[2-(aziridin-1-yl)acetyl]amino]heptyl]acetamide are often explored for their ability to selectively interact with biological targets. This can lead to highly specific therapeutic actions, which is a key goal in drug design.

Research Insights

In recent studies, aziridine-containing compounds have been highlighted for their potential to act as DNA-targeting agents. The reactivity associated with the aziridine ring can facilitate the formation of covalent bonds with nucleophilic sites in DNA, paving the way for innovative cancer treatment strategies.

The exploration of such compounds is not only significant in medicinal chemistry but also presents opportunities for the development of advanced materials. Scientists are keen to uncover the full scope of reactivity and applications that these compounds can offer.

As research continues to advance, the insights gained from studying compounds like 2-(aziridin-1-yl)-N-[7-[[2-(aziridin-1-yl)acetyl]amino]heptyl]acetamide may lead to groundbreaking discoveries in both the fields of therapeutics and material science.

Synonyms
6580-77-4
1-AZIRIDINEACETAMIDE, N,N'-(HEPTAMETHYLENE)BIS-
N,N'-Bis(aziridineacetyl)-1,7-heptamethylenediamine
1-Aziridineacetamide, N,N'-1,7-heptanediylbis-
8PE65M0PFC
NSC-111719
N,N'-1,7-Heptanediylbis(1-aziridineacetamide)
N,N'-(Heptamethylene)bis(1-aziridineacetamide)
NSC 111719
NSC111719
UNII-8PE65M0PFC
DTXSID30215988
1-Aziridineacetamide,N'-heptamethylenebis-
1-Aziridineacetamide,N'-1,7-heptanediylbis-
1-Aziridineacetamide, N,N'-heptamethylenebis-
N,N'-BIS(AZIRIDINYLACETYL)-1,7-HEPTAMETHYLENEDIAMINE