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Flutamide

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Identification
Molecular formula
C11H11ClFNO3
CAS number
13311-84-7
IUPAC name
2-benzamido-3-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]propanoic acid
State
State

Solid

At room temperature, Flutamide is a stable solid, usually handled in its powdered form for laboratory and pharmacological applications.

Melting point (Celsius)
110.00
Melting point (Kelvin)
383.15
Boiling point (Celsius)
502.90
Boiling point (Kelvin)
776.05
General information
Molecular weight
276.70g/mol
Molar mass
276.7040g/mol
Density
1.6108g/cm3
Appearence

Flutamide is a synthetic compound that appears as a yellow to yellow-green crystalline powder. It has no significant odor.

Comment on solubility

Solubility of 2-benzamido-3-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]propanoic acid

The solubility of 2-benzamido-3-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]propanoic acid is an intriguing aspect due to its complex chemical structure. Several factors can influence its solubility profile:

  • Polarity: The compound contains both polar and non-polar groups, which can lead to differential solubility in various solvents. Typically, compounds with polar functionalities are more soluble in polar solvents (like water) while non-polar groups favor non-polar solvents (like organic solvents).
  • Hydrogen Bonding: The presence of amide groups in the structure allows for potential hydrogen bonding with solvents, which may enhance solubility in water.
  • Chain Length: The extended hydrocarbon chains can hinder solubility in polar media by increasing hydrophobic interactions.
  • Ionization: The acid functional group can ionize, particularly at higher pH levels, which tends to increase solubility in aqueous solutions.

In summary, the solubility of this compound is influenced by its molecular structure, interactions with solvents, and environmental conditions. It may exhibit variable solubility, which could lead to differing outcomes depending on the medium in which it is placed. As a general guideline, one may often observe that such compounds demonstrate higher solubility in polar solvents while potentially remaining less soluble in non-polar environments.

Interesting facts

Interesting Facts about 2-Benzamido-3-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]propanoic Acid

This fascinating compound belongs to the class of synthetic molecules that have garnered attention in medicinal chemistry and pharmaceutical research. Here are some key insights:

  • Potential Therapeutic Uses: Due to its unique molecular structure, 2-benzamido-3-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]propanoic acid has been studied for its potential role in targeting specific cancer pathways, making it a subject of interest in oncological drug development.
  • Structure-Activity Relationship: The presence of both chloro and fluoro groups contributes to the compound's biological activity. This structural diversity allows chemists to optimize pharmacological effects and reduce toxicity in drug design.
  • Research and Innovation: Researchers are continuously exploring modifications of the core structure to enhance efficacy and selectivity, which highlights the ever-evolving nature of medicinal chemistry.
  • Analytical Techniques: Understanding compounds like this one often involves sophisticated analytical techniques, such as NMR spectroscopy and LC-MS (Liquid Chromatography-Mass Spectrometry), to accurately characterize their composition and properties.
  • Historical Context: The development of similar compounds has played a significant role in the evolution of therapeutic agents, leading to breakthroughs in treating various diseases.

In summary, 2-benzamido-3-[4-[2-chloroethyl(2-fluoroethyl)amino]phenyl]propanoic acid is more than just a chemical formula; it represents a complex interaction of structure, function, and potential in the realm of modern pharmacology. As with many compounds in medicinal chemistry, its study not only deepens our understanding of chemistry but also opens doors to new treatment options.

Synonyms
4252-37-3
N-Benzoyl-3-(p-((2-chloroethyl)(2-fluoroethyl)amino)phenyl)alanine
ALANINE, N-BENZOYL-3-(p-((2-CHLOROETHYL)(2-FLUOROETHYL)AMINO)PHENYL)-
NCIOpen2_009255
DTXSID20962550
NSC81147
NSC-81147
4-[(2-Chloroethyl)(2-fluoroethyl)amino]-N-[hydroxy(phenyl)methylidene]phenylalanine
1921-12-6