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Diphenhydramine

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Identification
Molecular formula
C17H21NO2
CAS number
147-24-0
IUPAC name
2-[[(benzhydrylamino)-(4-cyanoanilino)methylene]amino]acetic acid
State
State

Diphenhydramine exists as a solid at room temperature. It is typically handled as a crystalline powder for formulation into medicinal products.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
524.30
Boiling point (Kelvin)
797.50
General information
Molecular weight
255.34g/mol
Molar mass
255.3440g/mol
Density
1.1030g/cm3
Appearence

Diphenhydramine is a white, crystalline powder. It is nearly odorless and possesses a slightly bitter taste.

Comment on solubility

Solubility of 2-[[(benzhydrylamino)-(4-cyanoanilino)methylene]amino]acetic acid

The solubility of 2-[[(benzhydrylamino)-(4-cyanoanilino)methylene]amino]acetic acid (C17H21NO2) can be quite intriguing due to its complex structure. This compound exhibits specific solubility characteristics that are influenced by several factors:

  • Polarity: The presence of polar functional groups, such as carboxyl (-COOH) and amino (-NH2), leads to enhanced interaction with polar solvents, notably water.
  • Hydrogen bonding: The ability of the amino and carboxylic acid groups to form hydrogen bonds can increase solubility in polar solvents.
  • Solvent type: This compound is likely to be more soluble in solvents like methanol, ethanol, and water compared to non-polar solvents.
  • Temperature: As is common with many organic compounds, solubility can increase with temperature, potentially allowing for greater dissolution in warm solvents.

However, it is important to note that due to the presence of bulky benzhydryl and cyanoaniline groups, the overall solubility may still be limited in highly polar solvents, leading to a situation where:

"The intricate balance of structure and functional groups dictates the solubility landscape."

In summary, while 2-[[(benzhydrylamino)-(4-cyanoanilino)methylene]amino]acetic acid shows promise for solubility in polar solvents, the unique characteristics imparted by its hydrophobic and bulky components will undoubtedly play a significant role in its overall solubility profile. Areas of further research may shed light on optimizing conditions for dissolution in various applications.

Interesting facts

Interesting Facts about 2-[[(benzhydrylamino)-(4-cyanoanilino)methylene]amino]acetic acid

2-[[(benzhydrylamino)-(4-cyanoanilino)methylene]amino]acetic acid is a fascinating compound due to its unique structural characteristics and potential applications in various fields. Here are some notable facts about this chemical:

  • Complex Structure: The compound features a complex molecular structure that includes both benzhydrylamino and cyanoanilino moieties. This intricate arrangement contributes to its interesting chemical reactivity and biological interactions.
  • Potential Pharmacological Uses: Research has indicated that compounds like this have the potential to act as drug candidates, particularly in the fields of cancer therapy and anti-inflammatory treatments. The presence of the cyano group can enhance certain pharmacokinetic properties.
  • Synthesis Exploration: Synthesis of this compound presents a fascinating challenge for chemists. Methods often involve multi-step reactions, showcasing the ingenuity required to construct complex organic molecules.
  • Research Applications: Its structural components make it a valuable tool in medicinal chemistry research. Scientists can utilize this compound to study interactions with biological targets and develop new therapeutics.
  • Biological Activity: Preliminary studies indicate that similar compounds exhibit biological activity, which makes them interesting candidates for further investigation into their mechanism of action and efficacy.

In summary, 2-[[(benzhydrylamino)-(4-cyanoanilino)methylene]amino]acetic acid stands out as a compound worthy of further study, as its diverse structural elements may lead to groundbreaking discoveries in the fields of medicinal and organic chemistry.

Synonyms
CP-Dpm-GA
138460-25-0
N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
NC-174
MW7J9SU4JQ
CHEBI:385425
N-(4-Cyanophenyl)-N'-(diphenylmethyl)guanidineacetic acid
N-(p-Cyanophenyl)-N'-(diphenylmethyl)-N''-(carboxymethyl)guanidine
2-[[(benzhydrylamino)-(4-cyanoanilino)methylidene]amino]acetic acid
(N-(p-Cyanophenyl)-N'-(diphenylmethyl)guanidine)acetic acid
[N-(4-cyanophenyl)-N'-(diphenylmethyl)guanidine]acetic acid
(N(Z))-N-(((4-Cyanophenyl)amino)((diphenylmethyl)amino)methylene)glycine
2-[[(benzhydrylamino)-[(4-cyanophenyl)amino]methylidene]amino]ethanoic acid
Glycine, N-(((4-cyanophenyl)amino)((diphenylmethyl)amino)methylene)-, (N(Z))-
1808181-85-2
Glycine, N-[[(4-cyanophenyl)amino][(diphenylmethyl)amino]methylene]-
NC 174
GAS
nc174
N-(((4-Cyanophenyl)amino)((diphenylmethyl)amino)methylene)glycine
N-{[(4-cyanophenyl)amino][(diphenylmethyl)amino]methylene}glycine
Glycine, N-(((4-cyanophenyl)amino)((diphenylmethyl)amino)methylene)-
(z)-n-{[(4-cyanophenyl)amino][(diphenylmethyl)amino]methylidene}glycine
UNII-MW7J9SU4JQ
Epitope ID:161503
CHEMBL170077
DTXSID70930123
AKOS040753224
DB07816
PD004984
HY-117868
NS00068833
Q27097026
N-{(4-Cyanoanilino)[(diphenylmethyl)amino]methylidene}glycine
(E)-N-{[(4-cyanophenyl)amino][(diphenylmethyl)amino]methylidene}glycine