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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
2-benzhydryloxy-N,N-diethyl-ethanamine
State
State

At room temperature, diphenhydramine is a solid, often encountered in the form of tablets or capsules used for its antihistamine properties.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
291.00
Boiling point (Kelvin)
564.15
General information
Molecular weight
255.36g/mol
Molar mass
255.3580g/mol
Density
1.0000g/cm3
Appearence

Diphenhydramine is typically found as a white crystalline compound. It may appear as a slightly yellow powder when not pure. It is commonly encountered in a variety of formulations, such as tablets or capsules when used in medications.

Comment on solubility

Solubility of 2-benzhydryloxy-N,N-diethyl-ethanamine

2-benzhydryloxy-N,N-diethyl-ethanamine, also known as a tertiary amine with substituents contributing to its structure, exhibits particular characteristics with respect to its solubility behavior. Here are some key points regarding its solubility:

  • Solvent Dependency: The solubility of this compound is largely influenced by the nature of the solvent. Generally, organic solvents such as ethyl acetate or dichloromethane may dissolve it due to its non-polar characteristics.
  • Polarity: Being a tertiary amine, its solubility in water can be limited, especially when compared to primary and secondary amines. The presence of bulky benzhydryl groups can hinder the interaction with polar solvents.
  • pH Influence: The solubility may also vary with changes in pH. In an acidic environment, the amine can become protonated, potentially increasing its solubility in aqueous solutions.
  • Temperature Effects: Like many organic compounds, solubility can increase with temperature, leading to a greater dissolution of 2-benzhydryloxy-N,N-diethyl-ethanamine in heated solvents.

In summary, when studying the solubility of 2-benzhydryloxy-N,N-diethyl-ethanamine, it is essential to consider various factors such as solvent choice, polarity, pH, and temperature. These factors play a crucial role in determining how well this compound will dissolve in different environments.

Interesting facts

Interesting Facts about 2-benzhydryloxy-N,N-diethyl-ethanamine

2-benzhydryloxy-N,N-diethyl-ethanamine is a fascinating compound primarily studied in the field of medicinal chemistry. This compound can provide valuable insights into the interactions of drugs with biological systems. Here are some intriguing aspects of this compound:

  • Structure and Function: The molecule features a 2-benzhydryloxy group which is instrumental in enhancing stability and binding affinity to specific targets in the body. The presence of the N,N-diethyl groups contributes to its lipophilicity, facilitating its ability to cross cellular membranes.
  • Pharmacological Potential: Compounds like 2-benzhydryloxy-N,N-diethyl-ethanamine are often explored for their potential as therapeutic agents. Its structural characteristics may allow it to act on various neurotransmitter systems, making it a candidate for research in neurology and psychiatry.
  • Research Applications: The synthesis and study of such amines give chemists the tools to innovate new drugs. This compound can serve as a model for exploring structure-activity relationships (SAR), which is crucial for the design of more effective pharmaceuticals.
  • Chemical Behavior: Due to its functional groups, this compound may exhibit unique reactivity patterns. Understanding these patterns can lead to the development of novel synthetic pathways for other related compounds.
  • Continued Exploration: As science progresses, the investigation into the behavioral properties and biological effects of compounds like this one remains a dynamic area of study. Scientists continue to explore various analogs to expand our understanding of medicinal chemistry and pharmacology.

To quote a notable chemist, “Every molecule tells a story.” In the case of 2-benzhydryloxy-N,N-diethyl-ethanamine, the story is one of potential, exploration, and the ongoing quest to unlock new medical therapies.

Synonyms
Ethylbenzhydramine
642-58-0
Triethylamine, 2-(diphenylmethoxy)-
AH 966
Ethanamine, 2-(diphenylmethoxy)-N,N-diethyl-
UNII-B90W89D34H
BRN 1885294
N,N-Diethyl-2-(diphenylmethoxy)ethylamine
B90W89D34H
ETHYLBENZHYDRAMINE [MI]
ETHYLBENZHYDRAMINE [WHO-DD]
4-06-00-04660 (Beilstein Handbook Reference)
ETHYLAMINE, N,N-DIETHYL-2-(DIPHENYLMETHOXY)-
2-(BENZHYDRYLOXY)-N,N-DIETHYLETHYLAMINE
2-(DIPHENYLMETHOXY)-N,N-DIETHYLETHANAMINE
yjbneixmflqjpc-uhfffaoysa-n
2-benzhydryloxy-N,N-diethylethanamine
Oprea1_419041
CBDivE_003181
SCHEMBL147711
CHEMBL2097125
DTXSID90982745
2-(Diphenylmethoxy)-N,N-diethylethan-1-amine
Q27274518
Z197201018