Skip to main content

Orphenadrine citrate

ADVERTISEMENT
Identification
Molecular formula
C24H31NO9
CAS number
4682-36-4
IUPAC name
2-benzhydryloxy-N,N-dimethyl-ethanamine;8-chloro-1,3-dimethyl-7H-purine-2,6-dione
State
State

Orphenadrine citrate is typically found in a solid state at room temperature. Its crystalline structure is responsible for its stability and ease of handling as a solid.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.15
Boiling point (Celsius)
218.00
Boiling point (Kelvin)
491.15
General information
Molecular weight
461.95g/mol
Molar mass
461.9510g/mol
Density
0.9700g/cm3
Appearence

Orphenadrine citrate typically appears as a white crystalline powder. It is odorless and has a bitter taste. In its pure form, the compound is mostly used in pharmaceutical preparations.

Comment on solubility

Solubility of 2-benzhydryloxy-N,N-dimethyl-ethanamine; 8-chloro-1,3-dimethyl-7H-purine-2,6-dione

The solubility characteristics of a compound can significantly influence its application and effectiveness in various fields. When examining 2-benzhydryloxy-N,N-dimethyl-ethanamine and 8-chloro-1,3-dimethyl-7H-purine-2,6-dione, several factors must be considered:

  • Polarity: These compounds exhibit varying polarities due to the presence of functional groups, which can affect how well they dissolve in different solvents.
  • Solvent Interaction: The solubility may depend heavily on the solvent used. For instance, non-polar solvents may struggle to dissolve polar components whereas polar solvents might better accommodate these compounds.
  • Temperature Influence: Increasing the temperature typically enhances solubility, as molecules gain kinetic energy and interact more favorably with the solvent.
  • pH Levels: The solubility of the compounds is also affected by the pH of the solution. Ionizable groups can lead to increased solubility in basic or acidic environments.

It is crucial to consider these factors when determining the solubility of complex compounds like the ones mentioned. According to various studies, appropriate solvent selection and environmental conditions can lead to the best results in solubility endeavors. Understanding these elements not only aids in practical applications but also enriches academic discussions on such intriguing chemical substances.

Interesting facts

Interesting Facts about 2-benzhydryloxy-N,N-dimethyl-ethanamine; 8-chloro-1,3-dimethyl-7H-purine-2,6-dione

This compound is a fascinating example of how diverse chemical structures can lead to significant biological activity. It consists of two parts that highlight the complexity of modern organic chemistry.

Part 1: 2-benzhydryloxy-N,N-dimethyl-ethanamine

This segment of the compound showcases aminomethyl and benzhydryloxy functionalities, which play crucial roles in medicinal chemistry.

  • Drug Development: Compounds with similar structures are often researched for their potential CNS (Central Nervous System) applications.
  • Synthesis Pathways: It can be synthesized through several complex organic reactions, making it a subject of interest for synthetic chemists.
  • Biological Activity: Preliminary studies have shown promising activity, making it a candidate for new pharmaceuticals targeting specific receptors.

Part 2: 8-chloro-1,3-dimethyl-7H-purine-2,6-dione

As a member of the purine family, this segment is integral to various biological functions:

  • Base Analog: This compound acts as a structural analog of nucleobases, influencing DNA and RNA synthesis.
  • Research Applications: Often studied in the context of anti-cancer drugs, it highlights the ongoing search for effective chemotherapeutic agents.
  • Inhibition Studies: Its ability to inhibit certain enzymes adds to its significance in pharmacological research.

Overall, this compound exemplifies the merging of organic synthesis and medicinal chemistry, showcasing the importance of chemical research in developing new therapeutic agents. As scientists delve deeper into compounds like this, they continue to uncover the profound connections between molecular structure and biological function, paving the way for breakthroughs in treatment and drug design.

Synonyms
DIMENHYDRINATE
523-87-5
Travelin
Chloranautine
Diphenhydrinate
Vomex A
Anautine
Amosyt
Menhydrinate
Andramine
Diamarin
Dimenest
Dimentabs
Dramalen
Dramamin
Dramarin
Dramilin
Eldodram
Hydrinate
Novamine
Permital
Supremal
Teodramin
Travelmin
Troversin
Xamamina
Antemin
Dramyl
Dromyl
Reise-Engletten
Neo-Navigan
Diphenhydramine Theoclate
Dimenhidrinato
Lomarin
Reidamine
Removine
Emedyl
Faston
Gravinol (antiemetic)
Dimenhydrinatum
Dimenidrinato
Diphenhydramine 8-chlorotheophylline
JB937PER5C
Diphenhydramine 8-chlorotheophyllinate
NSC 117855
CCRIS 4798
DTXSID9025087
HSDB 3064
NCI-C60639
EINECS 208-350-8
UNII-JB937PER5C
Dimenhydrinatum [INN-Latin]
Dimenhidrinato [INN-Spanish]
O-Benzhydryldimethylaminoethanol 8-chlorotheophyllinate
DTXCID705087
(o-Benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate
Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline
N,N-Dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate
2-(Diphenylmethoxy)-N,N-dimethylethylamine 8-chlorotheophyllinate
beta-Dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine
NSC117855
8-Chlorotheophylline, compound with 2-(diphenylmethoxy)-N,N-dimethylethylamine (1:1)
2-(Benzhydryloxy)-N,N-dimethylethylamine 8-chlorotheophyllinate
Ethylamine 2-(diphenylmethoxy)-N,N-dimethyl-, compd with 8-chlorotheophylline (1:1)
Theophylline, 8-chloro-, compd with 2-(diphenylmethoxy)-N,N-dimethyethylamine (1:1)
Dimenhydrinatum (INN-Latin)
Dimenhidrinato (INN-Spanish)
DIMENHYDRINATE (MART.)
DIMENHYDRINATE [MART.]
DIMENHYDRINATE (USP-RS)
DIMENHYDRINATE [USP-RS]
DIMENHYDRINATE (EP IMPURITY)
Dimenhydrinate (USP:INN:BAN:JAN)
DIMENHYDRINATE [EP IMPURITY]
Dimenhydrinate [USP:INN:BAN:JAN]
DIMENHYDRINATE (EP MONOGRAPH)
DIMENHYDRINATE [EP MONOGRAPH]
DIMENHYDRINATE (USP MONOGRAPH)
DIMENHYDRINATE [USP MONOGRAPH]
Theoclate, Diphenhydramine
[o-Benzhydryl(dimethylamino)ethanol] 8-chlorotheophyllinate
Driminate
Emes
Epha
Airmit Ace
Dramamine Orange
Wal-dram
Dramamine for Kids
Dimenhydrinate 50mg
XAMAMINE
Dramamine Original Formula
2-(BENZHYDRYLOXY)-N,N-DIMETHYLETHYLAMINE 8-CHLOROTHEOPHTHEOPHYLLINATE
2-(BENZHYDRYLOXY)-N,N-DIMETHYLETHYLAMINE CMPD WITH 8 CHLOROTHEOPHYLLINE
2-(DIPHENYLMETHOXY)-N,N-DIMETHYLETHYLANIME CMPD WITH 8-CHLOROTHEOPHYLLINE (1:1
8-CHLOROTHEOPHYLLINE CMPD WITH 2-(DIPHENYLMETHOXY)-N,N-DIMETHYLAMINE (1:1)
1H-PYRINE-2,6-DIONE, 8-CHLORO-3,7-DIHYDRO-1,3-DIMETHYL-, COMPD WITH 2-(DIPHENYLMETHOXY)-N,N-DIMETHYLETHANAMINE (1:1)
2-(Diphenylmethoxy)-N,N-dimethylethylamine - 8-chloro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione (1/1)
208-350-8
8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
8-CHLORO-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE CMPD WITH 2-(DIPHENYLMETHOXY)-N,N-DIMETHYLETHANAMINE (1:1)
ETHANAMINE, 2-(DIPHENYLMETHOXY)-N,N-DIMETHYL-, COMPOUND WITH 8-CHLORO-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE (1:1)
ETHYLAMINE, 2-(DIPHENYLMETHOXY)-N,N-DIMETHYL-, COMPOUND WITH 8-CHLOROTHEOPHYLLINE (1:1)
THEOPHYLLINE, 8-CHLORO-, COMPOUND WITH 2-(DIPHENYLMETHOXY)-N,N-DIMETHYLETHYLAMINE (1:1)
chebi:4604
Dramamine
Aviomarin
Gravol
Gravinol
Dimate
MFCD00054265
NSC-117855
8-Chloro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione 2-(benzhydryloxy)-N,N-dimethylethanamine salt
Theohydramine
Dommanate
2-benzhydryloxy-N,N-dimethylethanamine;8-chloro-1,3-dimethyl-7H-purine-2,6-dione
8-chloro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione compound with 2-(benzhydryloxy)-N,N-dimethylethanamine (1:1)
Dimenidrinato [DCIT]
SR-05000001608
Dimenhydrinat
Dramamine (TN)
2-(diphenylmethoxy)-N,N-dimethylethanamine and 8-chloro-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione
Spectrum_000974
Prestwick3_000265
Spectrum2_000992
Spectrum3_000397
Spectrum4_000517
Spectrum5_000909
Dimenhydrinate (Standard)
DIMENHYDRINATE [MI]
SCHEMBL5128
DIMENHYDRINATE [INN]
DIMENHYDRINATE [JAN]
BSPBio_000110
BSPBio_002213
DIMENHYDRINATE [HSDB]
KBioGR_001093
KBioSS_001454
DIMENHYDRINATE [VANDF]
DivK1c_000049
SPECTRUM1500251
SPBio_001083
BPBio1_000122
DIMENHYDRINATE [WHO-DD]
CHEMBL1200406
CHEBI:94848
HMS500C11
HY-B1215R
KBio1_000049
KBio2_001454
KBio2_004022
KBio2_006590
KBio3_001433
Dimenhydrinate (JP18/USP/INN)
NINDS_000049
HMS1920G20
HMS2091O08
HMS2095F12
HMS3712F12
Pharmakon1600-01500251
Dimenhydrinate - Bio-X trade mark
HY-B1215
DIMENHYDRINATE [ORANGE BOOK]
Tox21_200323
CCG-40210
NSC756740
s4672
Dimenhydrinate for peak identification
AKOS015896341
AC-8241
CS-4841
DB00985
FD22159
NSC-756740
IDI1_000049
NCGC00021154-01
NCGC00021154-02
NCGC00021154-03
NCGC00021154-04
NCGC00021154-05
NCGC00021154-06
NCGC00021154-07
NCGC00091928-01
NCGC00091928-02
NCGC00091928-03
NCGC00257877-01
AS-13166
BD166163
SBI-0051350.P003
AB00053833
NS00076452
D00520
D82297
WLN: T56 BM DN FNVNVJ CG F H &622
EN300-37158633
Q420439
SR-05000001608-1
SR-05000001608-2
BRD-M98649031-001-01-1
BRD-M98649031-001-08-6
BRD-M98649031-001-09-4
8-chloro-6-hydroxy-1,3-dimethylpurin-2-one; diphenhydramine
Dimenhydrinate, European Pharmacopoeia (EP) Reference Standard
Dimenhydrinate, United States Pharmacopeia (USP) Reference Standard
Dimenhydrinate for peak identification, European Pharmacopoeia (EP) Reference Standard
Dimenhydrinate, Pharmaceutical Secondary Standard; Certified Reference Material
8-chloro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dionecompoundwith2-(benzhydryloxy)-N,N-dimethylethanamine(1:1)
8-chloro-1,3-dimethyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione; [2-(diphenylmethoxy)ethyl]dimethylamine
8-Chlorotheophylline 2-(diphenylmethoxy)-N,N-dimethylethylamine;2-(Diphenylmethoxy)-N,N-dimethylethylamine 8-chlorotheophyllinate;Am osyt
8-Chlorotheophylline 2-(diphenylmethoxy)-N,N-dimethylethylamine;2-(Diphenylmethoxy)-N,N-dimethylethylamine 8-chlorotheophyllinate;Am osyt
Diphenhydramine [2-(diphenylmethoxy)-N,N-dimethylethan-amine] 8-chlorotheophylline (8-chloro-1,3-dimethyl-3,7-dihy-dro-1H-purine-2,6-dione)