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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
147-24-0
IUPAC name
2-benzhydryloxyethyl(trimethyl)ammonium
State
State

At room temperature, diphenhydramine is usually found in a solid state as its hydrochloride salt form, which is a crystalline powder.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
214.00
Boiling point (Kelvin)
487.15
General information
Molecular weight
255.35g/mol
Molar mass
255.3530g/mol
Density
1.0093g/cm3
Appearence

Diphenhydramine hydrochloride, the form most commonly used in medications, typically appears as a white, crystalline powder. It is odorless and has a slightly bitter taste. This compound is highly soluble in water and alcohol.

Comment on solubility

Solubility of 2-benzhydryloxyethyl(trimethyl)ammonium

The solubility of 2-benzhydryloxyethyl(trimethyl)ammonium in various solvents is an intriguing aspect of this compound. Understanding its solubility profile can be essential for applications in chemical synthesis and formulation processes. Here are some key points regarding its solubility:

  • Polar Solvents: Compounds with quaternary ammonium groups, such as 2-benzhydryloxyethyl(trimethyl)ammonium, are typically soluble in polar solvents, including water and alcohols.
  • Non-Polar Solvents: On the other hand, the presence of the bulky benzhydryl groups may hinder its ability to dissolve in non-polar solvents, which can lead to poor solubility.
  • pH Dependence: The solubility can also be affected by the pH of the solution—an important consideration for any practical application.
  • Temperature Influence: Increasing temperature may enhance the solubility of this compound in solvents, facilitating its use in various chemical reactions.

In conclusion, while 2-benzhydryloxyethyl(trimethyl)ammonium exhibits good solubility in polar environments, its overall solubility can vary significantly depending on the presence of other chemical groups and environmental conditions. Therefore, it is crucial to evaluate the solubility characteristics when designing experiments involving this compound.

Interesting facts

Interesting Facts about 2-Benzhydryloxyethyl(trimethyl)ammonium

2-Benzhydryloxyethyl(trimethyl)ammonium is a fascinating compound that plays a significant role in the field of medicinal chemistry and pharmacology. Here are some intriguing aspects of this compound:

  • Quaternary Ammonium Compound: As a quaternary ammonium compound, it carries a permanent positive charge, which enhances its solubility in water and biological fluids, making it ideal for various applications in drug formulation.
  • Therapeutic Potential: Compounds of this type are often explored for their potential use as pharmacological agents, particularly in the treatment of neurological disorders due to their ability to cross the blood-brain barrier.
  • Structure-Activity Relationship (SAR): The unique structural features of 2-benzhydryloxyethyl(trimethyl)ammonium allow scientists to conduct SAR studies, aiding in the design of more effective and selective drugs. This can lead to varied activity against specific targets in biological systems.
  • Antimicrobial Properties: Many quaternary ammonium compounds exhibit antimicrobial activity, making them valuable in disinfectants and antiseptic formulations, showing promise for application in both healthcare and public health settings.

In summary, 2-benzhydryloxyethyl(trimethyl)ammonium stands out in the realm of chemistry not just for its structural complexity, but also for its versatile applications. Its ongoing study continues to unlock new therapeutic possibilities for enhancing human health. As the eminent chemist Linus Pauling once stated, "The structure of a substance is a key to its properties." Understanding and manipulating such compounds can lead to groundbreaking advancements in medicinal science.

Synonyms
Mefenidramium
Mefenidramium ion
Mefenidramium cation
UNII-65AZ72LF4X
65AZ72LF4X
29869-74-7
(2-(Diphenylmethoxy)ethyl)trimethylammonium
Ethanaminium, 2-(diphenylmethoxy)-N,N,N-trimethyl-
MEFENIDRAMIUM [WHO-DD]
DTXSID10274816
DTXCID70203465
CHEMBL540139
2-(diphenylmethoxy)-N,N,N-trimethylethanaminium
MLS006011448
CHEMBL1190119
SCHEMBL16887882
BDBM50225481
STK993694
AKOS005657804
NCGC00328846-01
SMR004703252
AB01322021-02
SR-01000945157
SR-01000945157-1
Q27263868