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2-Benzyl-1-(3,4-dichlorophenyl)guanidine

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Identification
Molecular formula
C14H13Cl2N3
CAS number
73439-57-7
IUPAC name
2-benzyl-1-(3,4-dichlorophenyl)guanidine
State
State
At room temperature, 2-benzyl-1-(3,4-dichlorophenyl)guanidine is typically a solid. It is not typically soluble in water but can be dissolved in organic solvents.
Melting point (Celsius)
188.50
Melting point (Kelvin)
461.65
Boiling point (Celsius)
441.00
Boiling point (Kelvin)
714.15
General information
Molecular weight
308.17g/mol
Molar mass
308.1710g/mol
Density
1.3470g/cm3
Appearence

This compound typically appears as a solid crystalline powder. The exact color can vary slightly but it is often off-white to light yellow.

Comment on solubility

Solubility of 2-benzyl-1-(3,4-dichlorophenyl)guanidine

The solubility of 2-benzyl-1-(3,4-dichlorophenyl)guanidine can be classified based on its chemical structure and interactions with various solvents. Understanding its solubility is crucial for applications in chemical research and pharmaceutical development.

Key Points on Solubility:

  • Polar vs. Non-Polar Solvents: This compound possesses polar functional groups (guanidine) that may enhance its solubility in polar solvents such as water and ethanolic solutions. However, its overall hydrophobic characteristics due to the benzyl and dichlorophenyl groups may limit this solubility.
  • Temperature Influence: Solubility is often temperature-dependent. It's expected that higher temperatures could increase solubility, allowing for better dissolution in various solvents.
  • pH Sensitivity: The ionization state of the guanidine functional group can be affected by the pH of the solution. In acidic environments, it may become protonated, enhancing its solubility in aqueous solutions.

In summary, while 2-benzyl-1-(3,4-dichlorophenyl)guanidine displays a level of solubility influenced by its structural characteristics, the precise solubility behavior can vary significantly with changes in solvent, temperature, and pH. As such, empirical experimentation is essential for determining the exact solubility profile of this compound in different conditions.

Interesting facts

Interesting Facts about 2-benzyl-1-(3,4-dichlorophenyl)guanidine

2-benzyl-1-(3,4-dichlorophenyl)guanidine is a fascinating compound that has garnered attention in various fields of research and medicinal chemistry. Below are some interesting insights into this compound:

  • Potent Pharmacological Activity: This compound exhibits significant pharmacological properties, particularly in the realm of anti-inflammatory and analgesic effects. It is often investigated for its potential therapeutic applications in treating pain and inflammation.
  • Structure-Activity Relationship (SAR): Understanding the SAR of this compound is crucial for optimizing its therapeutic efficacy. The presence of the benzyl and dichlorophenyl groups is believed to enhance its activity compared to other guanidine derivatives.
  • Mechanism of Action: Research suggests that this compound may interact with specific receptors in the nervous system, which could lead to modulation of pain pathways. Its ability to cross the blood-brain barrier makes it a strong candidate for neurological studies.
  • Synthesis Challenges: The synthesis of 2-benzyl-1-(3,4-dichlorophenyl)guanidine can be quite complex. Chemists often face challenges in achieving high yields and purity, making the development of efficient synthetic routes a topic of ongoing research.
  • Environmental Impact: Due to the presence of chlorine atoms in its structure, there is consideration regarding the environmental impact of this compound. The safety and biodegradability of pharmaceuticals are critical factors guiding current research.
  • Future Perspectives: With ongoing discoveries in medicinal chemistry, 2-benzyl-1-(3,4-dichlorophenyl)guanidine could pave the way for new drug formulations. The exploration of its analogs might lead to even more effective compounds.

In summary, 2-benzyl-1-(3,4-dichlorophenyl)guanidine stands out as a compound with promising biological activity, complex synthesis challenges, and potential for future development in therapeutic applications. Researchers continue to explore its properties and mechanisms, driving forward the field of medicinal chemistry.

Synonyms
Bayer 81174
BAY 81174
1-Benzyl-3-(3,4-dichlorophenyl)guanidine
17826-48-1
GUANIDINE, 1-BENZYL-3-(3,4-DICHLOROPHENYL)-
DTXSID60170450
Guanidine, N-(3,4-dichlorophenyl)-N'-(phenylmethyl)-
DTXCID1092941
Guanidine, N-(3,4-dichlorophenyl)-N'-(phenylmethyl)-(9CI)