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2-benzyl-3,4-dihydroisoquinoline

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Identification
Molecular formula
C16H17N
CAS number
30442-10-9
IUPAC name
2-benzyl-3,4-dihydro-1H-isoquinoline
State
State

At room temperature, 2-benzyl-3,4-dihydroisoquinoline is in a solid state, typically appearing as a powder or crystalline solid.

Melting point (Celsius)
36.00
Melting point (Kelvin)
309.15
Boiling point (Celsius)
416.00
Boiling point (Kelvin)
689.15
General information
Molecular weight
221.32g/mol
Molar mass
221.3020g/mol
Density
1.0898g/cm3
Appearence

2-Benzyl-3,4-dihydroisoquinoline typically appears as a pale yellow to off-white powder. It may also be found as a crystalline solid in some instances.

Comment on solubility

Solubility of 2-benzyl-3,4-dihydro-1H-isoquinoline

2-benzyl-3,4-dihydro-1H-isoquinoline, a compound with a complex structure, exhibits specific solubility characteristics that are worth noting:

  • Solvent Compatibility: This compound is generally more soluble in organic solvents such as ethanol, methanol, and chloroform. Its aromatic and cyclic structure facilitates interactions with non-polar and weakly polar solvents.
  • Water Solubility: Like many isoquinoline derivatives, 2-benzyl-3,4-dihydro-1H-isoquinoline has limited solubility in water. This is primarily due to the hydrophobic nature of the benzyl group and the isoquinoline ring system.
  • Temperature and pH Effects: The solubility can be influenced by temperature; higher temperatures typically improve solubility. Additionally, the pH of the solution may also play a role in solubility, particularly when considering possible ionization or protonation at different pH levels.

In summary, while 2-benzyl-3,4-dihydro-1H-isoquinoline showcases notable solubility in certain organic solvents, it remains relatively insoluble in aqueous environments. Its unique properties can facilitate its application in various organic synthesis reactions and pharmaceutical formulations.

Interesting facts

Interesting Facts about 2-benzyl-3,4-dihydro-1H-isoquinoline

2-benzyl-3,4-dihydro-1H-isoquinoline is an intriguing compound with a range of noteworthy characteristics. Here are some fascinating aspects of this compound that highlight its significance:

  • Structure and Chemistry: This compound contains a unique isoquinoline core, which is a bicyclic structure that is well-regarded in organic chemistry for its diverse reactivity and versatility in synthesis.
  • Bioactivity: Isoquinolines, including 2-benzyl-3,4-dihydro-1H-isoquinoline, have been recognized for their potential biological activities. Many compounds of this class exhibit important pharmaceutical properties. For example, they may possess antimicrobial, anticancer, and anti-inflammatory effects.
  • Synthetic Relevance: The synthesis of benzyl-substituted isoquinolines is often employed in the development of novel drugs. This compound can serve as a valuable precursor in the synthesis of more complex molecules, opening pathways for chemical innovations.
  • Research and Development: Ongoing research into isoquinoline derivatives continues to reveal their potential in medicinal chemistry. This highlights the importance of compounds like 2-benzyl-3,4-dihydro-1H-isoquinoline in drug discovery and development.
  • Citation of Significance: In academic literature, researchers often note that “the structural motifs present in isoquinolines are critical for modulating biological activity,” illustrating the compound's relevance in various fields.

In summary, 2-benzyl-3,4-dihydro-1H-isoquinoline stands out for its structural depth, biological potential, and significant contribution to synthetic organic chemistry. Investigating compounds like this not only enhances our understanding of chemical reactivity but also paves the way for new therapeutic agents in healthcare.

Synonyms
2-benzyl-1,2,3,4-tetrahydroisoquinoline
13605-95-3
Isoquinoline, 1,2,3,4-tetrahydro-2-(phenylmethyl)-
2-benzyl-3,4-dihydro-1H-isoquinoline
CHEMBL21272
Oprea1_499214
SCHEMBL693732
SCHEMBL697563
SCHEMBL2764499
SCHEMBL6640751
SCHEMBL8016854
SCHEMBL8016857
SCHEMBL10978742
SCHEMBL28205078
DTXSID60274780
BDBM50017029
STK119107
AKOS005400725
N-benzyl-1,2,3,4-tetrahydroisoquinoline
2-Benzyl-1,2,3,4-tetrahydro-isoquinoline
CS-0259386
G81693
EN300-7314996
Z54752168