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4-chloro-2-benzylphenol

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Identification
Molecular formula
C13H11ClO
CAS number
120-32-1
IUPAC name
2-benzyl-4-chloro-phenol
State
State

At room temperature, 4-chloro-2-benzylphenol is in a solid state. The substance is generally stable under recommended storage conditions, with its crystalline structure helping it maintain form.

Melting point (Celsius)
79.50
Melting point (Kelvin)
352.65
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
218.67g/mol
Molar mass
218.6730g/mol
Density
1.2650g/cm3
Appearence

4-Chloro-2-benzylphenol typically appears as a white to off-white crystalline powder. It may also sometimes present as a flake-like solid. The compound is known for its structural robustness due to the chlorine and benzyl substitutions on the phenolic ring, which also contribute to its distinct aromatic odor.

Comment on solubility

Solubility of 2-benzyl-4-chloro-phenol

2-benzyl-4-chloro-phenol, often referred to as a chlorinated phenolic compound, exhibits some intriguing solubility characteristics. Its solubility profile can be primarily influenced by factors such as temperature, pH, and the presence of other solvents. Here are some key points regarding its solubility:

  • Solvent Polarity: This compound tends to be more soluble in organic solvents such as ethanol and acetone compared to water due to its hydrophobic aromatic rings.
  • Aqueous Solubility: In water, 2-benzyl-4-chloro-phenol has limited solubility. Its polar phenolic -OH group provides some degree of interaction with water molecules; however, the bulky benzyl and chlorophenyl groups hinder full solvation.
  • Temperature Effects: Increasing temperature typically enhances the solubility of organic compounds, and this case is no exception. As temperature rises, so does its solubility in both organic and aqueous systems.
  • pH Dependency: The solubility may vary with pH changes; for instance, in strong alkaline conditions, deprotonation can occur which enhances solubility.

As a general observation, it is safe to say that while 2-benzyl-4-chloro-phenol finds greater affinity for non-polar solvents, it demonstrates limited aqueous solubility, leading to its classification as a compound with moderate to low solubility in water.

Interesting facts

Interesting Facts About 2-benzyl-4-chloro-phenol

2-benzyl-4-chloro-phenol is an intriguing compound that showcases a blend of organic chemistry and industrial applications. Here are some fascinating aspects of this chemical:

  • Dual Functionalities: This compound features both a benzyl group and a chloro substituent on its aromatic ring, granting it unique chemical reactivity and potential interactions which can be exploited in various synthetic pathways.
  • Applications in Antimicrobial Products: Due to its phenolic structure, 2-benzyl-4-chloro-phenol is often utilized for its antimicrobial properties. It can be found in formulations aimed at inhibiting the growth of bacteria and fungi.
  • Use in Chemical Synthesis: This compound can serve as a versatile intermediate in organic synthesis, making it a valuable precursor in the manufacture of various pharmaceuticals and fine chemicals.
  • Research Opportunities: Chemists are continually exploring the potential modifications and derivatives of phenolic compounds like 2-benzyl-4-chloro-phenol, opening avenues for developing new drugs with enhanced therapeutic effects.
  • Environmental Considerations: Understanding the environmental impact of chlorinated phenols is crucial, as their presence in ecosystems can raise concerns regarding toxicity and bioaccumulation in aquatic organisms.

In summary, 2-benzyl-4-chloro-phenol is more than just a chemical formula; it embodies a wealth of research potential and practical applications. As one delves deeper into its properties and behaviors, the versatility and impact of this compound can be appreciated, highlighting the remarkable versatility of organic chemicals in our daily lives.

Synonyms
2-Benzyl-4-chlorophenol
120-32-1
Clorophene
Clorofene
Chlorophene
O-BENZYL-P-CHLOROPHENOL
Phenol, 4-chloro-2-(phenylmethyl)-
Santophen 1
5-Chloro-2-hydroxydiphenylmethane
4-Chloro-2-benzylphenol
Neosabenyl
Septiphene
Benzylchlorophenol
Bio-Clave
Santophen I germicide
p-Chloro-o-benzylphenol
Santophen I
Santophen 1 flake
Clorofeno
Clorophene [USAN]
Ketolin H
Ketolin-H
o-Benzylchlorophenol
Orthobenzylparachlorophenol
Orthobenzyl-p-chlorophenol
Clorofenum
4-Chloro-2-(phenylmethyl)phenol
Caswell No. 083
Clorofenum [INN-Latin]
4-Chloro-alpha-phenyl-o-cresol
Clorofene [INN]
Clorofeno [INN-Spanish]
2-benzyl-4-chloro-phenol
4-Chloro-.alpha.-phenyl-o-cresol
NCI-C61201
ortho-benzyl-para-chlorophenol
Phenol, 4-chloro-2-benzyl-
NSC-59989
CCRIS 6205
HSDB 5179
Preventol BP
Nipacide BCP
o-Cresol, 4-chloro-alpha-phenyl-
4-Chloro-alpha-phenyl-ortho-cresol
EINECS 204-385-8
NSC 59989
benzyl chloro phenol
EPA Pesticide Chemical Code 062201
Clorophene (USAN)
BRN 1959194
Santophen 1 (TN)
DTXSID5020154
AI3-08523
7560BB0BO3
CLOROPHENE [MI]
NSC59989
CLOROPHENE [HSDB]
NSC 59989;Santophen
o-Cresol, 4-chloro-.alpha.-phenyl-
CLOROFENE [WHO-DD]
CLOROPHENE [MART.]
DTXCID30154
2-Hydroxy-5-chlorodiphenylmethane
4-06-00-04636 (Beilstein Handbook Reference)
chlorofene
NCGC00091532-02
NCGC00091532-04
Clorofenum (INN-Latin)
Clorofeno (INN-Spanish)
CLOROPHENE (MART.)
Sentiphene
Orthosan
CAS-120-32-1
MFCD00020140
4-Chloro-2-benzyl phenol
Clorophen
BioClave
KetolinH
UNII-7560BB0BO3
oBenzylchlorophenol
oBenzylpchlorophenol
pChloroobenzylphenol
2Benzyl4chlorophenol
4Chloro2benzylphenol
Orthobenzylpchlorophenol
4Chloroalphaphenylocresol
CHLOROPHENE, USAN
CHLOROPHENE [INCI]
oCresol, 4chloroalphaphenyl
WLN: QR DG B1R
4Chloroalphaphenylorthocresol
orthobenzyl-para-chlorophenol
SANTOPHEN L GERMICIDE
4Chloro2(phenylmethyl)phenol
SCHEMBL78119
5Chloro2hydroxydiphenylmethane
SANTOPHEN 1 GERMICIDE
MLS002454423
Phenol, 4chloro2(phenylmethyl)
CHEMBL1328919
2-Benzyl-4-chlorophenol, 95%
NCKMMSIFQUPKCK-UHFFFAOYSA-
2-BENZYL-4-CHLORO PHENOL
CHEBI:228003
HMS3041D07
4-chloranyl-2-(phenylmethyl)phenol
Tox21_111146
Tox21_202985
Tox21_400046
AKOS001434264
Tox21_111146_1
USEPA/OPP Pesticide Code: 062201
NCGC00091532-01
NCGC00091532-03
NCGC00091532-05
NCGC00091532-06
NCGC00260530-01
AC-10752
BS-20052
SMR000777843
DB-041547
HY-118547
B0812
CS-0066335
NS00008968
clorofene;chlorophene;2-benzyl-4-chlorophenol
EN300-21338
D03564
D88696
SBI-0653892.0001
A804486
Q22829551
Z104495406
204-385-8
Chlorophene;o-Benzyl-p-Chlorophenol; 4-Chloro-2-(phenylmethyl)phenol; 5-Chloro-2-hydroxydiphenylmethane; Benzyl-p-chlorophenol
InChI=1/C13H11ClO/c14-12-6-7-13(15)11(9-12)8-10-4-2-1-3-5-10/h1-7,9,15H,8H2