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Berbamine

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Identification
Molecular formula
C20H23NO3
CAS number
478-61-5
IUPAC name
2-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
State
State

At room temperature, Berbamine is in a solid state, commonly found as a crystalline powder.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
533.50
Boiling point (Kelvin)
806.70
General information
Molecular weight
363.47g/mol
Molar mass
363.4650g/mol
Density
1.2400g/cm3
Appearence

Berbamine typically appears as a white to off-white crystalline powder. Its appearance can vary slightly depending on the purity and specific form in which it is prepared or isolated.

Comment on solubility

Solubility of 2-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline

The solubility of 2-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline can be influenced by several factors, including its molecular structure, polarity, and the presence of functional groups. Let's break down its solubility characteristics:

  • Polarity: This compound contains methoxy groups, which can enhance solubility in polar solvents like water due to their ability to form hydrogen bonds.
  • Hydrophobic Regions: The benzyl group contributes to hydrophobic interactions, which can limit solubility in highly polar solvents.
  • Solvent Systems: Solubility is often higher in organic solvents like ethanol, dichloromethane, and acetone compared to water. Thus, a mixed solvent approach may be optimal.
  • Temperature: Solubility may increase with temperature, as is common with many organic compounds.

Overall, while the presence of methoxy groups may suggest reasonable solubility in polar environments, the hydrophobic components might create challenges for dissolving in pure water. Therefore, it’s essential to evaluate specific solvent conditions for practical applications. As always, experiments should verify theoretical predictions to determine optimal solubility conditions.

Interesting facts

Interesting Facts about 2-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline

The compound 2-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline is a part of the isoquinoline family, which is known for its diverse biological and pharmacological properties. Here are some intriguing aspects regarding this compound:

  • Structural Complexity: The presence of multiple methoxy groups and a benzyl substituent contributes to its intricate structure. This complexity can affect the compound's reactivity and binding interactions in biological contexts.
  • Biological Activity: Isoquinoline derivatives are often explored for their potential pharmaceutical applications. Research suggests that compounds similar to this one may exhibit capabilities such as antitumor, antioxidant, and antimicrobial properties, making them attractive candidates in medicinal chemistry.
  • Natural Occurrence: Compounds within this structural family can be found in various natural sources, including plants. This connection to nature often piques the interest of natural product chemists who seek to discover new therapeutic agents.
  • Synthetic Pathways: The synthesis of 2-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline can involve various strategies such as cyclization and alkylation. Understanding these synthetic routes not only enhances our knowledge of organic synthesis but also broadens the scope for creating related compounds.
  • Research Perspectives: Ongoing studies aim to elucidate the mechanisms through which this compound interacts at the molecular level, furthering our understanding of isoquinoline derivatives and their potential roles in therapeutic contexts.

This compound stands as a testament to the richness of organic chemistry and the exciting possibilities within the realm of drug discovery and development. With its promising properties and structural allure, it is certainly a molecule to keep an eye on in both academic and industrial research endeavors.

Synonyms
N-Benzyl salsolidine
19902-16-0
1-Methyl-2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
RefChem:162926
Benzylsalsolidine
N-Benzylsalsolidine
Salsolidine, 2-benzyl-
BRN 1543126
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-1-METHYL-2-(PHENYLMETHYL)-, (S)-
SCHEMBL28742794
DTXSID00941782
2-benzyl-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
2-Benzyl-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methyl-2-(phenylmethyl)isoquinoline