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2-Benzyloxyguanidine

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Identification
Molecular formula
C8H11N3O
CAS number
1033-26-1
IUPAC name
2-benzyloxyguanidine
State
State

At room temperature, 2-Benzyloxyguanidine is typically in a solid state. It can be handled as a stable solid powder under normal laboratory conditions.

Melting point (Celsius)
114.00
Melting point (Kelvin)
387.15
Boiling point (Celsius)
287.00
Boiling point (Kelvin)
560.15
General information
Molecular weight
177.21g/mol
Molar mass
177.2130g/mol
Density
1.2157g/cm3
Appearence

2-Benzyloxyguanidine appears as a white to off-white crystalline powder. It is generally crystalline in nature and can have a slightly grainy or chalky texture depending on the processing method used. The appearance is considered typical for many organic compounds with similar functional groups.

Comment on solubility

Solubility of 2-Benzyloxyguanidine

The solubility of 2-benzyloxyguanidine can be intriguing due to its unique structure. Understanding its solubility is key for applications in various chemical and biological contexts. Here are some primary considerations regarding its solubility:

  • Polarity: The compound features a benzyl group, which is hydrophobic, while the guanidine part enhances hydrophilicity. This dual characteristic can lead to varied solubility in different solvents.
  • Solvent Dependence: 2-benzyloxyguanidine is more likely to dissolve in polar solvents such as water or methanol due to its guanidine functionality, which can form hydrogen bonds.
  • Temperature Effects: As with many compounds, solubility often increases with temperature. Therefore, testing solubility at various temperatures may yield interesting results.
  • pH Influence: The solubility of guanidine derivatives is also pH-dependent. Under acidic conditions, the protonation of the guanidine group can significantly enhance solubility.

To summarize, the solubility of 2-benzyloxyguanidine is influenced by several factors including polarity, solvent choice, temperature, and pH. Understanding these aspects can aid researchers in effectively utilizing this compound in their specific applications.

Interesting facts

Interesting Facts About 2-Benzyloxyguanidine

2-Benzyloxyguanidine is a fascinating chemical compound known for its diverse applications in the field of medicinal chemistry. Here are some intriguing aspects of this compound:

  • Biological Activity: The compound has demonstrated considerable biological activity, particularly in the realm of neuroprotection and antioxidant properties, attracting interest for potential therapeutic uses.
  • Synthesis: Synthesizing 2-benzyloxyguanidine can be achieved through various chemical techniques, often involving the alkylation of guanidine derivatives, showcasing the rich chemistry underlying this process.
  • Role in Research: Due to its structural similarity to other biologically relevant compounds, it serves as a useful lead compound in drug design, enabling researchers to explore modifications that can enhance efficacy and safety.
  • Structure-Activity Relationships: Scientists study the structure-activity relationships (SAR) of 2-benzyloxyguanidine extensively to understand how variations in its structure can influence its biological properties and interactions with biological targets.
  • Field of Application: This compound is not only of interest in neuropharmacology but also shows promise in oncology and cardiovascular research, underscoring its potential versatility as a medicinal agent.

As we continue to explore the wonders of compounds like 2-benzyloxyguanidine, it becomes evident that even small structural changes can lead to significant implications in biological activity and therapeutic potential. The ongoing research into such compounds keeps the field of chemistry ever-evolving and ripe with opportunities for discovery.


Synonyms
GUANIDINE, (BENZYLOXY)-
705-98-6
benzyloxyguanidine
(Benzyloxy)guanidine
(Phenylmethoxy)guanidine
RP 13958
Guanidine, (phenylmethoxy)-
NSC 26368
BRN 1871521
SCHEMBL1741620
SCHEMBL8096704
DTXSID10220772
WWHZKHHZRIJLEM-UHFFFAOYSA-N
NSC26368
NSC-26368