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Edetic acid

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Identification
Molecular formula
C10H16N2O8
CAS number
60-00-4
IUPAC name
2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
State
State

At room temperature, edetic acid is in a solid state. It is stable under recommended storage conditions, which generally involve being kept in a cool, dry place away from direct sunlight.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
292.24g/mol
Molar mass
292.2430g/mol
Density
1.0100g/cm3
Appearence

Edetic acid typically appears as a white crystalline powder. The crystal form may vary, but it is often seen as fine, white crystals. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid

The compound 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid, with the formula C10H16N2O8, exhibits notable solubility characteristics that are quite fascinating. This chemical, often referred to as a polyamino acid derivative, has several functional groups that significantly influence its solubility.

Key Points on Solubility:

  • Highly Soluble in Water: Due to its multiple carboxymethyl groups, this compound is highly soluble in polar solvents, especially water. The presence of these carboxylate groups increases the compound's ability to interact with water molecules, facilitating dissolution.
  • pH Sensitivity: The solubility is also affected by the pH of the solution. Following an increase in pH, the deprotonation of carboxylic acid groups allows for even greater solubility, making it more effective in alkaline conditions.
  • Temperature Effects: Solubility may vary with temperature; generally, higher temperatures can enhance solubility as molecular motion increases, allowing for better interaction of solute and solvent.
  • Complexation with Metal Ions: This compound can form stable complexes with metal ions, which may alter its solubility profiles in solutions containing specific cations.

In summary, the solubility of 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid is profoundly influenced by its functional groups, environmental conditions such as pH and temperature, and the presence of other ions in solution. This makes it a versatile compound for various applications, particularly in biochemical and pharmaceutical formulations where solubility plays a crucial role.

Interesting facts

Interesting Facts about 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid

This fascinating compound is known for its complex structure and multifunctional properties, making it useful in various scientific applications.

Key Points:

  • Multi-Functional Ligand: This compound acts as a versatile ligand in coordination chemistry, linking metals and enhancing their solubility and reactivity.
  • Biological Significance: Its structure includes multiple carboxymethyl groups, which can bind metal ions effectively, making it useful in biological systems for metal transport.
  • Role in Chelation Therapy: Due to its affinity for metal ions, it can be utilized in chelation therapy, particularly for removing excess minerals or toxins from the human body.
  • Buffering Agent: This compound is an excellent buffering agent at physiological pH levels, which is beneficial in biochemical experiments and drug formulation.

Applications and Uses:

  • Chemistry Research: Employed as a reagent in various organic synthesis reactions, aiding in the study of reaction mechanisms.
  • Pharmaceutical Industry: Integral in the development of pharmaceuticals where metal ion binding is critical.
  • Biotechnology: Utilized in the purification processes for proteins and enzymes, assisting in achieving higher yields and purity.

The compound resembles a complex puzzle of interconnected amino acids, where every carboxymethyl group plays a distinctive role. As quoted in many studies, "the unique architecture of this compound allows it to interact with its environment in ways that simpler molecules cannot."

Its remarkable stability and chelation properties not only contribute to its scientific significance but also pave the way for new advancements in chemical and medical fields. Understanding its reactivity and interactions can lead to innovative applications in technology and healthcare.

Synonyms
Pentetic acid
diethylenetriaminepentaacetic acid
67-43-6
DTPA
Detapac
Detarex
Titriplex V
Perma kleer
Monaquest CAI
Hamp-Ex Acid
Penthanil
Dabeersen 503
CHEL 330 acid
Diethylenetriamine Pentaacetic Acid
Pentacarboxymethyldiethylenetriamine
Chel DTPA
Acido pentetico
Acide pentetique
Dissolvine D
H5dtpa
(Diethylenetrinitrilo)pentaacetic acid
Pentetate
Penthamil
Diethylenetriamine-N,N,N',N'',N''-pentaacetic acid
Acidum penteticum
DTP-A
1,1,4,7,7-Diethylenetriaminepentaacetic acid
DETPA
NSC 7340
Diethylene triamine pentaacetic acid
2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-
Monaquest
Diethylenetriaminepentacetic acid
N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine
NSC-7340
EINECS 200-652-8
UNII-7A314HQM0I
MFCD00004289
3,6,9-Triazaundecanedioic acid, 3,6,9-tris(carboxymethyl)-
BRN 1810219
NANODTPA
7A314HQM0I
Acide pentetique [INN-French]
Acido pentetico [INN-Spanish]
Acidum penteticum [INN-Latin]
N,N-bis[2-[bis(carboxymethyl)amino]ethyl]glycine
N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine
DTXSID2023434
CHEBI:35739
Glycine, N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-
NSC7340
(Diethylenetriamine)pentaacetic acid
Acetic acid, ((carboxymethylimino)bis(ethylenenitrilo))tetra-
N,N-Bis(2-(bis(carboxymethyl)amino)ethyl)glycine
2,2'-(Carboxymethylimino)bis(ethyliminodiessigsaeure)
NANODTPA COMPONENT DTPA
Acetic acid, 2,2',2'',2'''-(((carboxymethyl)imino)bis(2,1-ethanediylnitrilo))tetrakis-
DTXCID603434
Chel 330
(((Carboxymethyl)imino)bis(ethylenenitrilo))tetraacetic acid
EC 200-652-8
diethylenetriaminepentaacetate
4-04-00-02454 (Beilstein Handbook Reference)
N,N,N',N'',N''-diethylenetriaminepentaacetic acid
Pentetic acid [USAN:USP:INN:BAN]
Diethylenetriaminepentaacetic acid;DTPA
NANODTPA ZN-DTPA COMPONENT DTPA
CAS-67-43-6
NANO-DTPA CAPSULE COMPONENT DTPA
NCGC00015360-05
2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetic acid
Pentaind
2,2',2'',2''',2''''-(ethane-1,2-diylnitrilo)pentaacetic acid
PENTETIC ACID (II)
PENTETIC ACID [II]
N,N-Bis(2-[bis(carboxymethyl)amino]ethyl)glycine
Penthamil (VAN)
PENTETIC ACID (MART.)
PENTETIC ACID [MART.]
Acide pentetique (INN-French)
Acido pentetico (INN-Spanish)
Acidum penteticum (INN-Latin)
PENTETIC ACID (USP-RS)
PENTETIC ACID [USP-RS]
[[(Carboxymethyl)imino]bis(ethylenenitrilo)]tetraacetic acid
[[(carboxymethyl)imino]bis(1,2-ethanediylnitrilo)tetraacetic acid]
Pentetic acid (USAN:USP:INN:BAN)
PENTETIC ACID (USP MONOGRAPH)
PENTETIC ACID [USP MONOGRAPH]
Diethylenetriaminepentaacetic acid, 99%
2,2',2'',2'''-((((Carboxymethyl)azanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetraacetic acid
SR-01000075826
Acetic acid, [(carboxymethylimino)bis(ethylenenitrilo)]tetra-
pentetic-acid
(((carboxymethyl)imino)bis(1,2-ethanediylnitrilo)tetraacetic acid)
Diethylenetriaminepentaaceticacid
Acetic acid, 2,2',2'',2'''-[[(carboxymethyl)imino]bis(2,1-ethanediylnitrilo)]tetrakis-
Pentaacetic Acid, Diethylenetriamine
Penta(carboxymethyl)diethylenetriamine
Pentetic acid; DTPA
N-Carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)
Plexene D (Salt/Mix)
Syntron C (Salt/Mix)
Kiresuto P (Salt/Mix)
Tetralon B (Salt/Mix)
Prestwick0_000941
Prestwick1_000941
Prestwick2_000941
Prestwick3_000941
Lopac-D-6518
PENTETATE [VANDF]
Pentetic acid (Standard)
Chel 330 (Salt/Mix)
CHEMBL780
Pentetic acid (USP/INN)
PENTETIC ACID [MI]
PENTETIC ACID [INN]
Lopac0_000431
SCHEMBL17138
BSPBio_000902
PENTETIC ACID [USAN]
PENTETIC ACID [VANDF]
SPBio_003061
BPBio1_000994
PENTETIC ACID [WHO-DD]
(Carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid
HY-B1335R
V09AX01
V09CA01
BDBM610684
HMS1570N04
HMS2094E03
HMS2097N04
HMS3261G04
HMS3714N04
Pharmakon1600-01506082
HY-B1335
US10624871, Compound 12
Tox21_110131
Tox21_500431
AC-333
BBL002988
NSC759314
s4824
STK373226
WLN: QV1N1VQ2N1VQ2N1VQ1VQ
AKOS005446652
DTPA;Diethylenetriaminepentaacetic acid
Tox21_110131_1
CCG-204523
DB14007
FP29951
LP00431
NSC-759314
SDCCGSBI-0050416.P003
NCGC00015360-01
NCGC00015360-02
NCGC00015360-03
NCGC00015360-04
NCGC00015360-06
NCGC00015360-08
NCGC00015360-09
NCGC00015360-12
NCGC00093852-01
NCGC00093852-02
NCGC00093852-03
NCGC00261116-01
DA-52527
VS-01284
SBI-0050416.P002
1,4,7,7-Diethylenetriaminepentaacetic acid
AB00375916
CS-0013088
D0504
EU-0100431
NS00007493
D 6518
D05422
Diethylenetriaminepentaacetic acid, p.a., 99%
EN300-199939
AB00375916-04
AB00375916_05
DIETHYLENETRIAMINE PENTAACETIC ACID [VANDF]
Diethylenetriamine-N,N',N'',N''-pentaacetic acid
diethylenetriamine-n,n,n',n',n''-pentaacetic acid
Glycine,N-bis[2-[bis(carboxymethyl)amino]ethyl]-
Q416487
N,N-bis {2-[bis(carboxymethyl)amino]ethyl}glycine
SR-01000075826-1
SR-01000075826-4
BRD-K40621224-001-01-8
BRD-K40621224-001-06-7
Diethylenetriaminepentaacetic acid, >=98% (titration)
Diethylenetriaminepentaacetic acid, >=99% (titration)
N, {N-Bis[2-[bis(carboxymethyl)amino]ethyl]glycine}
Glycine, {N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-}
3,9-Triazaundecanedioic acid, 3,6,9-tris(carboxymethyl)-
DIETHYLENETRIAMINE- N,N,N',N',N''-PENTAACETIC ACID
DTPA, Diethylenetriamine-N,N,N',N'',N''-pentaacetic acid
(((Carboxymethyl)imino)bis(ethylenenitrilo))-tetraacetic acid
{[[(Carboxymethyl)imino]bis(ethylenenitrilo)]tetraacetic} acid
Acetic acid, {[(carboxymethylimino)bis(ethylenenitrilo)]tetra-}
Pentetic acid, United States Pharmacopeia (USP) Reference Standard
Acetic acid,2',2'',2'''-[[(carboxymethyl)imino]bis(2,1-ethanediylnitrilo)]tetrakis-
1004765-76-7
2,2',2'',2'''-(2,2'-(carboxymethylazanediyl)bis(ethane-2,1-diyl)bis(azanetriyl))tetraacetic acid
200-652-8