Skip to main content

Cyclophosphamide

ADVERTISEMENT
Identification
Molecular formula
C7H15Cl2N2O2P
CAS number
50-18-0
IUPAC name
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-one
State
State

At room temperature, Cyclophosphamide is typically a solid. For medical applications, it is usually dissolved and administered intravenously.

Melting point (Celsius)
50.00
Melting point (Kelvin)
323.00
Boiling point (Celsius)
489.00
Boiling point (Kelvin)
762.00
General information
Molecular weight
261.09g/mol
Molar mass
261.0940g/mol
Density
1.5800g/cm3
Appearence

Cyclophosphamide appears as a white crystalline powder. It is usually odorless or may have a slightly chloroform-like odor when in pure state. The compound is often supplied in its anhydrous form for medical uses which enhances stability and solubility.

Comment on solubility

Solubility of 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-4-one

The solubility of 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-4-one is a complex topic, influenced by a variety of factors related to its chemical structure. Understanding its solubility attributes can provide key insights into its behavior in different environments. Here are some notable points:

  • Polarity: The presence of polar functional groups may lead to increased solubility in polar solvents.
  • Hydrogen Bonding: This compound's ability to form hydrogen bonds can enhance its solubility in water and similar solvents.
  • Solvent Compatibility: Ideal solvents for solubility tests may include dimethyl sulfoxide (DMSO) or ethanol, as they can interact favorably with the functional groups present.
  • Temperature: Changes in temperature often influence the solubility of compounds, and elevated temperatures might improve the solubility of this compound as well.

The interplay of these factors means that solubility tests need to be conducted under controlled conditions to yield reliable results. Thus, while initial assumptions may suggest limited solubility due to its complex structure, it is essential to conduct thorough studies to accurately characterize its solubility behavior.

Interesting facts

Interesting Facts about 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2<lambda>5-oxazaphosphinan-4-one

This unique compound, often referred to as a member of the oxazaphosphinan family, showcases an intriguing combination of phosphorus and nitrogen chemistry. As a scientist, delving into this compound can be particularly enlightening due to its applications and structural characteristics.

Applications and Relevance

  • Chemotherapeutic Agent: This compound is notably studied for its potential use in cancer therapy, playing a role as an alkylating agent.
  • Pharmaceutical Research: Its unique structure makes it a target for synthesizing new medications, particularly in the development of anti-cancer drugs.
  • Research Tool: The synthesis and modification of this compound can help researchers understand the interactions between various functional groups and their biological activities.

Structural Insights

The structure of this compound is quite complex and features a remarkable blend of functional groups. Some key highlights include:

  • Oxazaphosphinan Ring: The oxazaphosphinan moiety contributes to the chemical uniqueness and stability of the compound.
  • Chloroethyl Amino Groups: The two bis(2-chloroethyl)amino groups provide reactive sites, enhancing its potential biological activity.
  • Phosphorus-oxygen Bonding: The presence of phosphorus introduces properties that are distinct compared to traditional organic compounds.

Important Considerations

While studying this compound, it is essential to take into account:

  • Toxicity Assessment: Understanding its potential toxicity is crucial for any medicinal application.
  • Mechanism of Action: Investigating how this compound interacts with biological molecules can unveil new pathways for therapeutic use.
  • Environmental Impact: As with many chemical compounds, evaluating its environmental footprint is important for responsible usage.

In summary, 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2<lambda>5-oxazaphosphinan-4-one stands as a fascinating example of the intersection between inorganic and organic chemistry, paving the way for innovative approaches in medicine and beyond.

Synonyms
4-Ketocyclophosphamide
27046-19-1
4-Oxocyclophosphamide
N9DU5QVF19
NSC-139488
DTXSID501031077
2-(Bis(2-chloroethyl)amino)tetrahydro-4H-1,3,2-oxazaphosphorin-4-one 2-oxide
2-[Bis(2-chloroethyl)amino]tetrahydro-4H-1,3,2-oxazaphosphorin-4-one 2-Oxide
2-(bis(2-chloroethyl)amino)-2-oxo-1,3,2$l^(5)-oxazaphosphinan-4-one
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2$l^{5}-oxazaphosphinan-4-one
RefChem:99536
DTXCID401516115
4-Oxo Cyclophosphamide
Oxo-Endoxan
Asta 5160
NSC 139488
CCRIS 5128
CHEBI:1887
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-one
4H-1,3,2-Oxazaphosphorin-4-one, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide
UNII-N9DU5QVF19
BRN 5582971
orb1694438
CHEMBL3544546
KETOCYCLOPHOSPHAMIDE, 4-
SCHEMBL23802152
VBMZHOCORXMDJU-UHFFFAOYSA-N
MFCD30720490
NSC139488
AKOS040754750
2-[bis(2-chloroethyl)amino]-1,3,2
HY-W740674
4H-1,3,2-Oxazophosphorin-4-one, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide
PD150830
C07644
G79445
Q27105518
2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinan-4-one 2-oxide
2-[bis(2-chloroethyl)amino]-1,3,2|E?-oxazaphosphinane-2,4-dione
2-[Bis(2-chloroethyl)amino]-1,3,2-oxazaphosphinan-4-one 2-oxide #
4H-1,2-Oxazaphosphorin-4-one, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide