Skip to main content

Chlorambucil

ADVERTISEMENT
Identification
Molecular formula
C14H19Cl2N3O2
CAS number
305-03-3
IUPAC name
2-[bis(2-chloroethyl)amino]-N-[2-[[2-[bis(2-chloroethyl)amino]acetyl]amino]ethyl]acetamide
State
State

At room temperature, Chlorambucil is typically in a solid state. It exists as a crystalline powder which is stable under prescribed storage conditions.

Melting point (Celsius)
64.00
Melting point (Kelvin)
337.15
Boiling point (Celsius)
550.00
Boiling point (Kelvin)
823.15
General information
Molecular weight
304.23g/mol
Molar mass
304.6770g/mol
Density
1.2850g/cm3
Appearence

Chlorambucil appears as a pale yellow to yellow-brown crystalline powder. It may exhibit varying shades of yellow depending on its purity and exposure to light or air over time.

Comment on solubility

Solubility of 2-[bis(2-chloroethyl)amino]-N-[2-[[2-[bis(2-chloroethyl)amino]acetyl]amino]ethyl]acetamide

The solubility of the compound 2-[bis(2-chloroethyl)amino]-N-[2-[[2-[bis(2-chloroethyl)amino]acetyl]amino]ethyl]acetamide can vary significantly depending on several factors. Understanding its solubility traits is crucial for its application in chemical processes. Here are some important points regarding its solubility:

  • Polar vs. Non-Polar Solvents: This compound is likely to display higher solubility in polar solvents due to the presence of multiple amine and acetamide functional groups. These groups can interact favorably with polar molecules.
  • Temperature Dependency: The solubility may also increase with temperature. As the temperature rises, the kinetic energy of the molecules increases, often leading to enhanced solubility.
  • pH Sensitivity: In aqueous solutions, the solubility might be influenced by pH levels. If the compound ionizes in specific pH ranges, its solubility can increase.
  • Concentration Effects: At very high concentrations, solubility limits might be reached, leading to precipitation. Understanding the critical concentration points is essential for practical applications.

In summary, the solubility of 2-[bis(2-chloroethyl)amino]-N-[2-[[2-[bis(2-chloroethyl)amino]acetyl]amino]ethyl]acetamide demonstrates complex behavior influenced by solvent choice, temperature, pH, and concentration. Such factors make it vital to conduct detailed solubility studies tailored to the intended application.

Interesting facts

Interesting Facts about 2-[bis(2-chloroethyl)amino]-N-[2-[[2-[bis(2-chloroethyl)amino]acetyl]amino]ethyl]acetamide

This compound, often referred to as a derivative of a well-known chemotherapeutic agent, brings a lot to the table in the world of medicinal chemistry. Here are some intriguing aspects:

  • Mechanism of Action: The presence of two 2-chloroethyl groups makes it an alkylating agent. This means it can react with DNA, leading to cross-linking and inhibiting cellular replication, particularly in rapidly dividing cancer cells.
  • Medical Application: Compounds like this are designed for cancer treatment, especially in targeting specific malignancies, showcasing the intersection of organic chemistry and oncology.
  • Derivative Nature: This compound's design echoes that of classic chemotherapeutic agents, showcasing how scientists modify existing structures to enhance efficacy or reduce toxicity.
  • Synthesis Complexity: The synthesis of such compounds often involves multi-step organic reactions, requiring a deep understanding of organic synthesis techniques and the reactivity of amines and acyl chlorides.
  • Research Status: Investigations are ongoing to determine its effectiveness and safety through clinical trials, emphasizing the continuous evolution of cancer treatment protocols.
  • Side Effects: As with many alkylating agents, there can be considerable side effects related to the non-specific nature of the drug, affecting healthy cells alongside cancerous ones.

As we advance in the field of medicinal chemistry, compounds like this epitomize the challenges and triumphs faced in drug development. It’s a reminder of the delicate balance between innovation and patient safety in the pursuit of effective therapies.