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Chlorambucil

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Identification
Molecular formula
C14H19Cl2NO2
CAS number
305-03-3
IUPAC name
2-[bis(2-chloroethyl)amino]-N-methyl-N-phenyl-acetamide
State
State

At room temperature, chlorambucil is typically a solid.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
341.14
Boiling point (Kelvin)
614.29
General information
Molecular weight
304.21g/mol
Molar mass
304.2090g/mol
Density
1.3980g/cm3
Appearence

Chlorambucil is a yellow, crystalline solid that can appear in the form of a powder or small crystals. It is typically stable when no light is present.

Comment on solubility

Solubility of 2-[bis(2-chloroethyl)amino]-N-methyl-N-phenyl-acetamide

2-[bis(2-chloroethyl)amino]-N-methyl-N-phenyl-acetamide is a compound with a notable solubility profile, particularly relevant in various chemical contexts. Understanding its solubility characteristics can provide insights into its behavior in different solutions.

Key Aspects of Solubility

  • Solvent Dependence: The solubility of this compound can vary significantly depending on the solvent used. It tends to be more soluble in polar solvents due to the presence of amine functional groups.
  • Temperature Influence: Generally, increasing the temperature enhances solubility. This property is crucial for applications requiring higher concentrations of the compound in solution.
  • pH Sensitivity: Changes in pH can affect its solubility, especially since it contains nitrogen atoms (from the amine groups) that can interact with protons. Therefore, it may show improved solubility in acidic conditions.
  • Concentration Limits: At high concentrations, precipitation can occur, indicating that there is a limit to how much of the compound can remain dissolved at a given temperature and solvent.

In practical applications, it's essential to consider these factors when formulating solutions or conducting experiments. The importance of achieving the right solubility cannot be overstated as it directly influences reactivity, bioavailability, and overall effectiveness in its intended use.

Interesting facts

Interesting Facts about 2-[bis(2-chloroethyl)amino]-N-methyl-N-phenyl-acetamide

This compound, known for its significant role in medicinal chemistry, offers a great deal of intriguing information that captures the attention of both researchers and students alike. Here are some noteworthy points:

  • Chemotherapy Connection: 2-[bis(2-chloroethyl)amino]-N-methyl-N-phenyl-acetamide is structurally similar to well-known alkylating agents often used in chemotherapy. Its ability to modify DNA through alkylation makes it a candidate for anti-cancer research.
  • Multi-functional Grouping: The existence of both chlorine and amine functionalities contributes to the compound's reactivity. This multifunctionality may increase its pharmacological potential by enabling interactions with various biological targets.
  • Toxicity Concerns: While compounds like this may exhibit therapeutic effects, they also pose toxicity risks. Understanding the mechanisms of cytotoxicity is crucial in developing safer derivatives for medical applications.
  • Structure-Activity Relationship (SAR): The exploration of the SAR allows chemists to optimize the efficacy and reduce side effects. Variations in the substituents can lead to significant changes in the compound's biological activity.
  • Impact on Drug Design: The development and study of such compounds pave the way for new drug formulations, enhancing tailored therapies for diseases that are otherwise difficult to treat.

In conclusion, the study of 2-[bis(2-chloroethyl)amino]-N-methyl-N-phenyl-acetamide helps illuminate the complexities of chemical interactions in biological systems. As researchers continue to delve deeper into the properties and effects of this compound, it stands as a testament to the evolving landscape of medicinal chemistry.