Skip to main content

2-bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone

ADVERTISEMENT
Identification
Molecular formula
C12H13BrN2O
CAS number
477600-75-2
IUPAC name
2-bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone
State
State
The compound is typically a solid at room temperature with a crystalline powder form.
Melting point (Celsius)
166.50
Melting point (Kelvin)
439.65
Boiling point (Celsius)
377.00
Boiling point (Kelvin)
650.15
General information
Molecular weight
295.15g/mol
Molar mass
295.1430g/mol
Density
1.4965g/cm3
Appearence

The compound appears as a crystalline solid, often presenting as a white to off-white powder. The appearance can vary slightly depending on the specific synthesis method used.

Comment on solubility

Solubility of 2-bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone

The solubility of 2-bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone is influenced by several factors due to its complex structure. Understanding the solubility characteristics of this compound is essential for its application in various chemical processes. Here are some key points regarding its solubility:

  • Solvent Dependence: This compound is likely to exhibit varying solubility in different solvents, with polar solvents such as methanol or ethanol potentially enhancing its solubility due to the presence of the dimethylamino group, which can engage in hydrogen bonding.
  • Hydrophobic Interactions: The presence of hydrophobic aromatic components may reduce solubility in purely polar solvents and favor solubility in organic solvents like dichloromethane.
  • Temperature Effects: In many cases, solubility increases with temperature, so heating the solution may improve the 2-bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone solubility.

As with many organic compounds, it is critical to perform empirical tests to ascertain the exact solubility profile, as theoretical predictions can often deviate from practical results. In summary, the solubility of 2-bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone is a multifaceted topic that calls for consideration of solvent choice, environmental conditions, and the specific interactions at play.

Interesting facts

Interesting Facts about 2-Bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone

2-Bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone is a fascinating chemical compound that resides at the intersection of medicinal chemistry and organic synthesis. Here are some key points worth noting:

  • Structural Complexity: This compound contains both a bromo-group and an indole moiety, contributing to its intriguing structural characteristics that are often explored in pharmaceuticals.
  • Indole Derivatives: Indoles are significant in medicinal chemistry due to their presence in numerous natural products and their importance in drug development.
  • Biological Activity: Compounds with similar structures are frequently studied for their potential anti-cancer and anti-inflammatory properties, making this compound of interest for therapeutic research.
  • Dimethylamino Group: The dimethylamino substitution enhances the compound's ability to interact with biological systems, affecting both its solubility and potential mechanism of action.
  • Potential Applications: Researchers are continually investigating the synthesis and reactivity of such compounds, looking into their roles as *precursors* in drug discovery and *lead compounds* in medicinal formulations.

In summary, 2-bromo-1-[5-(dimethylamino)-1H-indol-3-yl]ethanone exemplifies the **diverse possibilities** that exist within the realm of organic compounds. Its unique structure and potential applications continue to attract the attention of chemists and researchers aiming to harness its properties for future advancements in medicine.

Synonyms
6851-69-0
BRN 0398180
INDOLE, 3-BROMOACETYL-5-(DIMETHYLAMINO)-
5-(Dimethylamino)-3-bromoacetylindole
DTXSID80218641
DTXCID30141132