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2-Bromo-5-nitrothiazole

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Identification
Molecular formula
C3HBrN2O2S
CAS number
3034-47-5
IUPAC name
2-bromo-5-nitro-thiazole
State
State

At room temperature, 2-Bromo-5-nitrothiazole is a solid.

Melting point (Celsius)
101.00
Melting point (Kelvin)
374.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
211.02g/mol
Molar mass
211.0210g/mol
Density
2.0108g/cm3
Appearence

2-Bromo-5-nitrothiazole typically appears as a pale yellow to yellow crystalline powder. The compound can display a slightly dull or glowing texture depending on the granularity of the sample. Its appearance may vary slightly based on purity and method of crystallization.

Comment on solubility

Solubility of 2-bromo-5-nitro-thiazole

2-bromo-5-nitro-thiazole is a compound that exhibits notable characteristics concerning its solubility. Typically, the solubility of thiazole derivatives is influenced by their structural features, particularly the presence of halogens and nitro groups.

  • Polarity: The bromo and nitro groups contribute to the overall polarity of the molecule. This increased polarity can enhance interactions with polar solvents.
  • Solvent Compatibility: 2-bromo-5-nitro-thiazole is likely to be soluble in polar solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Dimethylformamide (DMF)
  • Insulation from Non-Polar Solvents: Conversely, it is expected to have low solubility in non-polar solvents due to its polar character.
  • Hydrogen Bonding: The presence of the nitro group may allow for potential hydrogen bonding with solvents, further influencing solubility.

In summary, while specific solubility values may vary, understanding the molecular interactions is key. As a general guideline, “the greater the polarity, the better the solubility in polar solvents.” Therefore, when working with 2-bromo-5-nitro-thiazole, it is advisable to use polar solvents for optimal dissolution.

Interesting facts

Interesting Facts about 2-Bromo-5-nitro-thiazole

2-Bromo-5-nitro-thiazole is a fascinating compound with a variety of applications in medicinal chemistry and organic synthesis. Here are some engaging details about this compound:

  • Structure and Function: The molecular structure of 2-bromo-5-nitro-thiazole features a thiazole ring, which is known for its unique properties. The presence of both a bromine and a nitro group makes it a valuable candidate for various chemical reactions.
  • Importance in Drug Discovery: This compound is often studied in the context of antimicrobial agents, as it displays potential activity against a range of pathogens. Compounds like these are crucial for developing new therapeutic agents in the fight against resistant strains of bacteria.
  • Chromogenic Properties: 2-Bromo-5-nitro-thiazole has been noted for its ability to act as a chromophore, which makes it useful in fluorescence studies and imaging. This application is particularly exciting in the realm of biosensors and diagnostics.
  • Versatile Synthetic Intermediate: In organic synthesis, it serves as an intermediate for creating other complex compounds. Its derivatives can lead to novel materials with desirable electronic or optical properties.
  • Environmental Considerations: As more research focuses on green chemistry, understanding the reactivity and degradation pathways of compounds like 2-bromo-5-nitro-thiazole is vital. This awareness fosters the development of safer chemical processes.

In summary, 2-bromo-5-nitro-thiazole exemplifies the intersection of organic chemistry and pharmaceutical research, showcasing its importance in both industrial applications and academic studies. Whether investigating its molecular properties or exploring its potential in drug development, this compound continues to intrigue scientists.

Synonyms
2-Bromo-5-nitrothiazole
3034-48-8
THIAZOLE, 2-BROMO-5-NITRO-
EINECS 221-226-8
NSC 91531
BRN 0004856
DTXSID4062804
4-27-00-00963 (Beilstein Handbook Reference)
DTXCID5038175
anijfzvzxzqfdh-uhfffaoysa-n
2-Bromo-5-nitro-1,3-thiazole
5-Nitro-2-bromothiazole
MFCD00005317
NSC-91531
D98LNW2P5U
SCHEMBL384751
2-Bromo-5-nitrothiazole, 98%
NSC91531
2-Bromo-5-nitro-1,3-thiazole #
BBL027514
STK937403
AKOS000279589
AC-7664
CS-W001966
FB12599
RS-1007
BP-13020
SY003502
B4413
NS00028902
EN300-122584