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2-Bromo-N-(2-tert-butyl-6-methylphenyl)acetamide

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Identification
Molecular formula
C13H18BrNO
CAS number
65947-90-2
IUPAC name
2-bromo-N-(2-tert-butyl-6-methyl-phenyl)acetamide
State
State

At room temperature, 2-Bromo-N-(2-tert-butyl-6-methylphenyl)acetamide is typically found as a solid. It is stable under normal conditions and should be stored in a dry place.

Melting point (Celsius)
73.50
Melting point (Kelvin)
346.70
Boiling point (Celsius)
257.50
Boiling point (Kelvin)
530.60
General information
Molecular weight
282.20g/mol
Molar mass
282.1810g/mol
Density
1.3260g/cm3
Appearence

2-Bromo-N-(2-tert-butyl-6-methylphenyl)acetamide appears as a crystalline solid, often colorless to white in appearance. It may exhibit a mild, characteristic odor typical of phenyl or brominated organic compounds.

Comment on solubility

Solubility of 2-bromo-N-(2-tert-butyl-6-methyl-phenyl)acetamide

2-bromo-N-(2-tert-butyl-6-methyl-phenyl)acetamide, a compound featuring both bromo and amide functional groups, presents an intriguing profile when it comes to solubility. Solubility is primarily influenced by the balance between polar and non-polar characteristics in a compound. In this case:

  • Polarity: The presence of the amide functional group typically enhances the polar character of the molecule, allowing it to engage in hydrogen bonding.
  • Hydrophobic Regions: The tert-butyl and methyl groups contribute significantly to the non-polar части, which can hinder solubility in polar solvents.
  • Solvent Interaction: This compound may exhibit limited solubility in water, while being more soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and methanol.

Considering these factors, it can be said that:

  1. In polar solvents, its solubility may be restricted due to the hydrophobic interactions.
  2. In non-polar solvents, the bulky groups may aid in increasing solubility.

In conclusion, understanding the solubility of 2-bromo-N-(2-tert-butyl-6-methyl-phenyl)acetamide requires a nuanced view of its functional groups and molecular structure. The balance between polar and non-polar aspects is crucial in predicting how this compound interacts with different solvents, emphasizing the complexity of solubility behavior in chemical compounds.

Interesting facts

Interesting Facts about 2-bromo-N-(2-tert-butyl-6-methyl-phenyl)acetamide

2-bromo-N-(2-tert-butyl-6-methyl-phenyl)acetamide is a fascinating compound within the realm of organic chemistry, primarily due to its unique structure and potential applications. Here are some key points to delve into:

  • Functional Groups: This compound contains both a bromo group and an amide functional group, influencing its reactivity and solubility in various solvents.
  • Use in Synthesis: It can serve as a valuable building block in the synthesis of more complex molecules, particularly in pharmaceuticals and agrochemicals.
  • Biological Activity: Compounds with bromo substituents often exhibit interesting biological activities, including antimicrobial and anti-inflammatory properties, which makes them worth studying for drug development.
  • Steric Hindrance: The tert-butyl group is noteworthy for introducing steric hindrance, which can impact the compound's interactions with biological targets, affecting its potency and selectivity.
  • Psychoactive Research: Investigations into related amides have led to discoveries in psychoactive properties, opening new avenues in neuropharmacology.

In the words of chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." 2-bromo-N-(2-tert-butyl-6-methyl-phenyl)acetamide exemplifies this sentiment by showcasing how varied structural features can be leveraged for innovative applications.

As research progresses, the exploration of this compound's potential continues to unveil new insights and opportunities in the fields of medicinal chemistry and beyond. Understanding its properties and behavior paves the way for innovative solutions in science and industry.

Synonyms
2-tert-Butyl-6-methylbromoacetanilide
CP 32179
BRN 2730035
6873-41-2
Acetamide, 2-bromo-N-(2-(1,1-dimethylethyl)-6-methylphenyl)-
DTXSID30218858
o-ACETOTOLUIDIDE, 2-BROMO-6'-tert-BUTYL-
DTXCID80141349
Acetamide, 2-bromo-N-(2-(1,1-dimethylethyl)-6-methylphenyl)-(9CI)
SCHEMBL7223579
Acetamide, 2-bromo-N-(2-(1,1-dimethylethyl)-6-methylphenyl)- (9CI)