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2-Bromo-N-methyl-N-phenylacetamide

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Identification
Molecular formula
C9H10BrNO
CAS number
2250-49-3
IUPAC name
2-bromo-N-methyl-N-phenyl-acetamide
State
State

At room temperature, 2-Bromo-N-methyl-N-phenylacetamide exists as a solid. Its solid state stems from the strong intermolecular forces present in the crystalline lattice of the compound.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
228.09g/mol
Molar mass
228.0770g/mol
Density
1.4030g/cm3
Appearence

2-Bromo-N-methyl-N-phenylacetamide typically appears as a white to off-white crystalline solid. Its crystalline nature gives it a solid appearance that might resemble fine particles or powder. The compound is often devoid of any significant odor. The appearance can slightly change based on purity and the presence of any impurities.

Comment on solubility

Solubility of 2-bromo-N-methyl-N-phenyl-acetamide

2-bromo-N-methyl-N-phenyl-acetamide, with the chemical structure featuring a bromine substituent on the nitrogen-containing acetamide backbone, exhibits interesting solubility characteristics. Understanding its solubility is crucial for applications in pharmaceuticals and chemical synthesis.

Key points about the solubility of this compound include:

  • Polar Functional Groups: The acetamide group contributes to its polar nature, enhancing the ability to interact with polar solvents.
  • Hydrophobic Phenyl Ring: The presence of the phenyl group introduces hydrophobic characteristics, which may limit solubility in highly polar solvents.
  • Solvents: Typically, 2-bromo-N-methyl-N-phenyl-acetamide may show better solubility in:
    • Organic solvents such as ethanol and dimethyl sulfoxide (DMSO)
    • Moderately polar solvents, depending on temperature and concentration
  • Temperature Dependency: Like many organic compounds, its solubility may increase with temperature, allowing for greater dissolution in target solvents.

In summary, 2-bromo-N-methyl-N-phenyl-acetamide's solubility is influenced by its unique molecular structure, where the balance between polar and non-polar characteristics plays a significant role in determining its behavior in various solvents. Understanding these solubility properties can aid in the development and application of this compound in numerous chemical contexts.

Interesting facts

Interesting Facts about 2-Bromo-N-methyl-N-phenyl-acetamide

2-Bromo-N-methyl-N-phenyl-acetamide is a fascinating compound in the field of organic chemistry, notable for its diverse applications and unique properties. Here are a few intriguing aspects of this compound:

  • Pharmaceutical Relevance: This compound and its derivatives have shown potential as intermediates in the synthesis of various pharmaceuticals, especially in the development of analgesics and anti-inflammatory agents.
  • Structure and Reactivity: The presence of the bromo substituent significantly alters the reactivity of the acetamide. It can facilitate nucleophilic substitution reactions, making it a valuable building block in organic synthesis.
  • Importance of Substituents: The N-methyl and N-phenyl groups contribute to the compound’s stability and influence its biological activity. Substituents can critically adjust how molecules interact at the molecular level.
  • Research Potential: Ongoing research into brominated compounds highlights their utility in medicinal chemistry, particularly in the context of developing compounds with enhanced potency and specificity.

As highlighted by one researcher, "Understanding the nuanced properties of halogenated amides like 2-bromo-N-methyl-N-phenyl-acetamide opens avenues for drug development and optimization that were previously unexplored." The versatility of this compound makes it a subject of continued interest and relevance in modern chemistry.

In summary, 2-bromo-N-methyl-N-phenyl-acetamide is not just another chemical entity, but a compound with significant implications for both academic research and practical applications in the pharmaceutical industry.

Synonyms
2-bromo-N-methyl-N-phenylacetamide
RefChem:467174
803-485-4
29182-97-6
Acetamide, 2-bromo-N-methyl-N-phenyl-
ACETANILIDE, 2-BROMO-N-METHYL-
MFCD01671340
2-Bromo-N-methyl-N-phenyl-acetamide
2-Bromo-N-methylacetanilide
(Bromoacetyl)methylaminobenzene
BRN 2091429
N-Fenyl-N-methylamid kyseliny bromoctove [Czech]
N-Fenyl-N-methylamid kyseliny bromoctove
3-12-00-00466 (Beilstein Handbook Reference)
SCHEMBL2189058
DTXSID80183441
ALBB-031585
N-methyl-N-phenyl-2-bromoacetamide
SBB080042
STL066906
AKOS000319659
AJ-32520
DA-18581
LS-11464
SY079355
CS-0314978
ST45048917
E85483
2-Bromo-N-methyl-N-phenylacetamide, AldrichCPR
182B976
F038506
F3310-0578