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2-Bromo-3-hydroxypyridine

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Identification
Molecular formula
C5H4BrNO
CAS number
6630-36-6
IUPAC name
2-bromopyridin-3-ol
State
State

At room temperature, 2-bromo-3-hydroxypyridine is a solid.

Melting point (Celsius)
112.00
Melting point (Kelvin)
385.00
Boiling point (Celsius)
243.00
Boiling point (Kelvin)
516.00
General information
Molecular weight
172.00g/mol
Molar mass
172.0100g/mol
Density
1.8200g/cm3
Appearence

2-Bromo-3-hydroxypyridine is a crystalline compound that appears as off-white to pale yellow solid.

Comment on solubility

Solubility of 2-bromopyridin-3-ol

2-bromopyridin-3-ol, with its unique structure, showcases a remarkable solubility profile that is influenced by its functional groups. This compound is known to exhibit:

  • Moderate solubility in polar solvents: Due to the presence of the -OH (hydroxyl) group, 2-bromopyridin-3-ol can readily dissolve in polar solvents like water and ethanol.
  • Limited solubility in non-polar solvents: The aromatic nature of the pyridinic ring restricts solubility in non-polar solvents, making it less effective in environments devoid of polarity.
  • Influence of temperature: Like many organic compounds, its solubility may increase with temperature, allowing for greater mixing and interaction in solutions.

It is important to consider the chemical’s environmental impact, as solubility can significantly affect its behavior in biological systems and its potential as a solvent or reagent. As stated, “solubility plays a crucial role in determining the functionality and application of a chemical compound,” which highlights the importance of understanding the solubility of 2-bromopyridin-3-ol in various contexts.

Interesting facts

Intriguing Insights into 2-bromopyridin-3-ol

2-bromopyridin-3-ol is a fascinating compound that belongs to the class of brominated pyridines, which are characterized by the presence of a bromine atom on the pyridine ring. This particular structure leads to some notable properties and uses:

  • Biological Activity: This compound has gained attention for its potential biological activity. Research indicates that brominated pyridines can exhibit antimicrobial, anti-inflammatory, and even anticancer properties.
  • Building Block: 2-bromopyridin-3-ol serves as an important synthetic intermediate in the chemical industry. It is frequently used as a precursor in the synthesis of pharmaceuticals and agrochemicals.
  • Reactivity: The presence of the hydroxyl (-OH) group and bromine atom makes this compound reactive in various chemical processes. Its reactivity allows it to undergo substitutions and facilitate various coupling reactions.
  • Research Applications: Scientists are increasingly exploring the use of 2-bromopyridin-3-ol in various fields, notably in medicinal chemistry where its derivatives may lead to the development of new therapeutic agents.
  • Stereochemistry: As a compound featuring a chiral center, studies surrounding its stereochemistry are crucial for understanding how different stereoisomers may exhibit varying biological activities.

As noted by researchers, *"The unique combination of functional groups in 2-bromopyridin-3-ol allows it to engage in intriguing chemical reactivity, making it a valuable compound in modern chemistry."*
This highlights the compound's versatility and relevance in advancing both chemical knowledge and practical applications in industries ranging from pharmaceuticals to agriculture.

Synonyms
2-Bromo-3-hydroxypyridine
2-Bromopyridin-3-ol
2-Bromo-3-pyridinol
BRN 0109829
EINECS 229-547-5
UNII-9DAB85H359
9DAB85H359
DTXSID8022242
YKHQFTANTNMYPP-UHFFFAOYSA-
5-21-02-00086 (Beilstein Handbook Reference)
SKF 75250
2Bromopyridin3ol
3Pyridinol, 2bromo
2Bromo3hydroxypyridine
DTXCID602242
inchi=1/c5h4brno/c6-5-4(8)2-1-3-7-5/h1-3,8h
ykhqftantnmypp-uhfffaoysa-n
6602-32-0
3-PYRIDINOL, 2-BROMO-
2-Bromo-pyridin-3-ol
MFCD00006220
2-bromanylpyridin-3-ol
2-bromo-3-hydroxy-pyridine
2-BROMO-3-HYDROXY PYRIDINE
2-Bromo3-pyridinol
2-Bromo-3-pyridol
2-Bromopyridine-3-ol
2-bromo-pyridine-3-ol
3-hydroxy-2-bromopyridine
2-Bromo-3-hydroxypyridine (2-Bromo-3-pyridinol)
SCHEMBL66814
2-Bromo-3-pyridinol, 99%
ALBB-008720
BCP22484
CS-D0714
BBL013305
STK505526
AKOS000321204
AC-3247
FB34400
PB28951
HY-20026
SY004806
TS-03587
DB-020604
B1478
NS00047004
EN300-53585
AC-907/30002046
Q27272396
F2147-0555
8N0