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Irbesartan

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Identification
Molecular formula
C25H28N6O
CAS number
138402-11-6
IUPAC name
2-butyl-6-hydroxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-4-one
State
State
Irbesartan is typically in a solid state at room temperature, presented in a crystalline form.
Melting point (Celsius)
180.00
Melting point (Kelvin)
453.20
Boiling point (Celsius)
754.50
Boiling point (Kelvin)
1 027.70
General information
Molecular weight
428.53g/mol
Molar mass
428.4970g/mol
Density
1.4150g/cm3
Appearence

Irbesartan is a white to off-white crystalline powder, often observed in pharmaceutical forms such as tablets.

Comment on solubility

Solubility of 2-butyl-6-hydroxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-4-one

The solubility of a compound like 2-butyl-6-hydroxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-4-one (C25H28N6O) can be quite complex due to its intricate structure. Several factors influence its solubility, which can be categorized as follows:

  • Polarity: The presence of hydroxyl groups typically increases solubility in polar solvents like water. However, the extensive hydrophobic aromatic components in this compound may hinder its overall polarity, affecting its solubility.
  • Functional Groups: The presence of both hydroxy and tetrazole functionalities indicates that this compound might exhibit varied solubility characteristics depending on the solvent used. For instance, a solvent that can engage in hydrogen bonding may dissolve the compound better.
  • Temperature: As with many organic compounds, elevating the temperature usually enhances solubility. However, this must be experimentally established, as compounds can behave differently at varied temperatures.

In general, it is crucial to **test the solubility** of this compound in various solvents to accurately determine its potential applications. One might hear the saying, “*Like dissolves like*,” which emphasizes the importance of matching solvent types to the compound’s structural attributes.

To fully assess the solubility behavior of this compound, systematic experiments in different environments are recommended. Understanding its solubility will not only impact its practical applications but also aid in predicting its behavior in biological systems.

Interesting facts

Interesting Facts about 2-butyl-6-hydroxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-4-one

This chemical compound is an intriguing member of the quinazolinone family, which has garnered attention in medicinal chemistry for its potential therapeutic properties. Here are some fascinating insights:

  • Versatile Chemical Structure: The molecular architecture of this compound is quite complex, featuring a quinazolin-4-one core linked to multiple functional groups, including a butyl chain and a tetrazole moiety. This diversity in structure can enhance its bioactivity.
  • Therapeutic Potential: Compounds like this one are often studied for their pharmacological properties. They may exhibit anti-inflammatory, anti-cancer, or antimicrobial activities, opening avenues for drug discovery.
  • Tetrazole Significance: The presence of the tetrazole ring lends distinct properties to the molecule. Tetrazoles are known for their bioisosteric behavior, often replacing carboxylic acids in drug design, thus improving drug action or bioavailability.
  • Research Applications: Compounds of this nature are frequently investigated in the fields of neuropharmacology and cancer research. Scientists are keen on exploring how modifications to their structure affect their biological activities.
  • Analytical Techniques: Understanding the behavior and interactions of this compound often requires advanced analytical methods such as NMR spectroscopy, mass spectrometry, and X-ray crystallography, which provide insights into its structure and function.

In conclusion, 2-butyl-6-hydroxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-4-one serves as a fine example of how intricate chemical structures can lead to significant scientific investigation. As researchers continue to uncover its potential, the implications for drug development remain a point of significant interest in the field.

Synonyms
l-159,061
CHEMBL26514
2-BUTYL-6-HYDROXY-3-[2'-(1H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-3H-QUINAZOLIN-4-ONE
SCHEMBL9402007
BDBM36640
UNVNHFHIKCWHHG-UHFFFAOYSA-N
2-butyl-6-hydroxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-4-one
Q27449865
2-Butyl-6-hydroxy-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-4(3H)-quinazolinone
2-butyl-6-hydroxy-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}quinazolin-4(3H)-one