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2-chloro-1-(5-nitro-2-furyl)ethanone

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Identification
Molecular formula
C6H4ClNO4
CAS number
709-44-0
IUPAC name
2-chloro-1-(5-nitro-2-furyl)ethanone
State
State

At room temperature, this compound is typically found as a solid.

Melting point (Celsius)
46.00
Melting point (Kelvin)
319.15
Boiling point (Celsius)
327.70
Boiling point (Kelvin)
600.90
General information
Molecular weight
191.55g/mol
Molar mass
191.5480g/mol
Density
1.5390g/cm3
Appearence

2-Chloro-1-(5-nitro-2-furyl)ethanone is a pale yellow solid. It is usually found in crystalline form and has a distinctive appearance due to its nitro group, which imparts a yellowish color.

Comment on solubility

Solubility of 2-chloro-1-(5-nitro-2-furyl)ethanone

The solubility of 2-chloro-1-(5-nitro-2-furyl)ethanone is an important characteristic that influences its behavior in chemical processes. This compound is known to exhibit specific solubility traits:

  • Polar Solvents: Generally, 2-chloro-1-(5-nitro-2-furyl)ethanone shows good solubility in polar solvents such as water, methanol, and ethanol. This is due to the presence of electronegative chlorine and nitro groups that enhance interactions with polar solvent molecules.
  • Non-Polar Solvents: On the other hand, its solubility in non-polar solvents is quite limited. Solvents like hexane or benzene may not effectively dissolve this compound due to lack of significant polarity.
  • Temperature Effects: As with many organic compounds, temperature can affect solubility. An increase in temperature usually promotes solubility, allowing better dissolution of the compound in various solvents.

In practical applications, understanding the solubility of 2-chloro-1-(5-nitro-2-furyl)ethanone is crucial for processes like extraction and formulation, making it vital for chemists to consider these solubility characteristics when working with this compound. As the solvent environment is crucial, it’s advisable to always conduct solubility tests under expected working conditions.

Interesting facts

Exploring 2-chloro-1-(5-nitro-2-furyl)ethanone

2-chloro-1-(5-nitro-2-furyl)ethanone is a fascinating compound that showcases the unique properties of chlorinated and nitro-substituted organic molecules. Here are some intriguing facts about this compound:

  • Reactivity: This compound contains both a chlorine atom and a nitro group, which significantly influence its chemical reactivity. The presence of chlorine makes it a potent electrophile, while the nitro group introduces remarkable electron-withdrawing capacity.
  • Biological Activity: 2-chloro-1-(5-nitro-2-furyl)ethanone is of interest in the pharmaceutical field, particularly in the synthesis of potential drug candidates. Compounds with a furan ring, like the one in this structure, often exhibit various biological activities, making them valuable in medicinal chemistry.
  • Versatile Synthetic Intermediate: Due to its functional groups, this compound can serve as an essential intermediate in organic synthesis. It allows for easy modifications and derivatizations, paving the way for creating more complex molecules.
  • Environmental Impact: The use of chlorinated compounds in various applications often raises environmental concerns. Understanding the degradation pathways of such substances is crucial, as they can have long-lasting effects on ecosystems.
  • Analytical Methods: Different spectroscopic techniques, including NMR and mass spectrometry, are utilized to characterize this compound and confirm its structure. This highlights the importance of analytical chemistry in studying complex organic compounds.

In summary, 2-chloro-1-(5-nitro-2-furyl)ethanone is a compound that not only holds synthetic potential but also serves as a reminder of the intricate relationships between molecular structure, reactivity, and biological activity. As with many organic compounds, understanding its properties can lead to exciting discoveries in both scientific research and practical applications.

Synonyms
NIFURMERONE
5579-95-3
Metofurone
Nifurmerona
Nifurmeronum
NF-71
Ethanone, 2-chloro-1-(5-nitro-2-furanyl)-
2-Chloro-1-(5-nitrofuran-2-yl)ethan-1-one
2-chloro-1-(5-nitrofuran-2-yl)ethanone
NF 71
Nifurmerone [USAN:INN]
Chloromethyl 5-nitro-2-furyl ketone
NSC-84429
Ketone, chloromethyl 5-nitro-2-furyl
F57Y390K2N
NIFURMERONE [INN]
(Chlormethyl)(5-nitro-2-furyl)keton
NIFURMERONE [USAN]
2-Chloro-1-(5-nitro-2-furyl)ethanone
5-NITRO-2-FURYL KETONE
DTXSID90204358
NSC 84429
DTXCID90126849
101-716-7
UNII-F57Y390K2N
Nifurmerone (USAN/INN)
2-chloroacetyl-5-nitrofuran
SCHEMBL398798
CHEMBL2106787
FAA57995
NSC84429
CCG-40502
AKOS006273133
AKOS040753267
NS00121107
D05163
EN300-1268482
Q27277663
Z1198155433