Interesting facts
Interesting Facts about 2-chloro-10-[3-(dimethylamino)propyl]phenothiazin-3-ol
This compound belongs to the phenothiazine class of drugs, which are primarily recognized for their properties as antipsychotics. Here are some remarkable features of 2-chloro-10-[3-(dimethylamino)propyl]phenothiazin-3-ol:
- Structure and Functionality: The phenothiazine structure consists of a three-ring system specifically designed to interact with various neurotransmitter systems, making it a crucial player in psychiatric medications.
- Mechanism of Action: As a diverse antipsychotic compound, it primarily works by blocking dopamine D2 receptors in the brain, which alleviates symptoms of schizophrenia and severe anxiety.
- Dimethylamino Group: The presence of the dimethylamino side chain enhances the compound's pharmacological activity, increasing its affinity for the dopamine receptors and enhancing its therapeutic effects.
- Historical Significance: Phenothiazines were among the first class of drugs used in psychiatry, marking a significant advancement in the treatment of mental disorders in the mid-20th century.
- Broad Therapeutic Use: Beyond its use in treating schizophrenia, this compound has been utilized to manage conditions such as severe nausea and vomiting due to its antiemetic properties.
In conclusion, 2-chloro-10-[3-(dimethylamino)propyl]phenothiazin-3-ol serves as a fascinating example of how specific chemical structures can profoundly influence biological activity and therapeutic use. Its development represents a critical milestone in pharmaceutical history, providing hope and improved quality of life to countless individuals.
Synonyms
3-Hydroxychlorpromazine
3930-47-0
PHENOTHIAZINE, 2-CHLORO-10-(3-(DIMETHYLAMINO)PROPYL)-3-HYDROXY-
2-Chloro-3-hydroxy-10-(3-(dimethylamino)propyl)phenothiazine
10H-Phenothiazin-3-ol, 2-chloro-10-(3-(dimethylamino)propyl)-
10H-Phenothiazin-3-ol, 2-chloro-10-[3-(dimethylamino)propyl]-
BRN 1224593
DTXSID90192544
SOUCXKDIHOVGPW-UHFFFAOYSA-N
Phenothiazin-3-ol, 2-chloro-10-[3-(dimethylamino)propyl]-
3-HYDROXY-2-CHLOROPROMAZINE
NS00113917
Q63399754
2-Chloro-10-[3-(dimethylamino)propyl]-10H-phenothiazin-3-ol #
Solubility of 2-chloro-10-[3-(dimethylamino)propyl]phenothiazin-3-ol
The solubility of 2-chloro-10-[3-(dimethylamino)propyl]phenothiazin-3-ol in various solvents exhibits interesting characteristics typical of complex organic compounds. Understanding its solubility profile is crucial for its applications in pharmaceuticals and related fields. Here are some key points regarding its solubility:
As a general rule, compounds containing hydroxyl, amine, and ionic groups tend to be more soluble in water. However, those with extensive hydrocarbon moieties may struggle to dissolve. Thus, the solubility of 2-chloro-10-[3-(dimethylamino)propyl]phenothiazin-3-ol can be summarized as
In conclusion, understanding the solubility behavior of this compound is essential for optimizing its usage in different chemical environments as well as in pharmaceutical formulations.