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Clonidine hydrochloride

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Identification
Molecular formula
C9H10Cl2N3
CAS number
4205-91-8
IUPAC name
2-chloro-3-(4,5-dihydro-1H-imidazol-1-ium-2-ylmethyl)aniline;chloride
State
State

Clonidine hydrochloride is typically in a solid state at room temperature, appearing as a crystalline powder.

Melting point (Celsius)
298.00
Melting point (Kelvin)
571.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
266.56g/mol
Molar mass
266.5580g/mol
Density
1.2817g/cm3
Appearence

Clonidine hydrochloride appears as a white to almost white crystalline powder. It is hygroscopic and soluble in water and alcohol, forming a clear, colorless solution.

Comment on solubility

Solubility of 2-chloro-3-(4,5-dihydro-1H-imidazol-1-ium-2-ylmethyl)aniline;chloride

The solubility of 2-chloro-3-(4,5-dihydro-1H-imidazol-1-ium-2-ylmethyl)aniline; chloride can be characterized by several key factors:

  • Polarity: The presence of the chloride ion and the imidazolium group suggests a certain degree of polarity in the compound, which may facilitate its solubility in polar solvents such as water.
  • Hydrogen Bonding: The imidazolic structure is capable of forming hydrogen bonds, which can enhance solubility in polar solvents. This characteristic is crucial because strong intermolecular interactions increase solubility.
  • Solvent Compatibility: It may demonstrate better solubility in organic solvents, such as methanol or ethanol, which are known to solubilize such cationic compounds effectively.

Overall, while specific quantitative solubility data can vary, it is anticipated that the cationic nature of the compound paired with its polar functional groups will result in good solubility in polar solvents and variable solubility in nonpolar solvents. The balance of these factors will ultimately define the practical applications of this compound in various fields.

Interesting facts

Interesting Facts about 2-chloro-3-(4,5-dihydro-1H-imidazol-1-ium-2-ylmethyl)aniline;chloride

The compound 2-chloro-3-(4,5-dihydro-1H-imidazol-1-ium-2-ylmethyl)aniline;chloride is a fascinating example of a chemical with potential implications in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Dual Functionality: This compound contains both a chlorinated aromatic aniline moiety and an imidazolium structure. This combination may enhance its biological activity, making it a candidate for various pharmaceutical applications.
  • Imidazolium Influence: Compounds containing imidazolium derivatives are often associated with ionic liquids, which have unique properties such as low volatility and high thermal stability. Their presence in this structure might suggest interesting solvent and catalytic properties.
  • Biological Relevance: The imidazole ring is known for its role in biological systems. It is a key component of the amino acid histidine and is involved in enzyme catalysis, suggesting potential biological significance for this compound in enzymatic reactions.
  • Applications in Drug Design: Compounds with similar structural motifs have been studied for their potential as antimicrobial agents, anticancer drugs, and anti-inflammatory compounds. This prompts further investigation into the pharmacological properties of this particular compound.
  • Structural Diversity: The presence of various functional groups, including the chloro group and the imidazolium ring, highlights the synthetic versatility and potential for modification in drug development, allowing chemists to explore a wide range of derivatives for enhanced efficacy.

In conclusion, 2-chloro-3-(4,5-dihydro-1H-imidazol-1-ium-2-ylmethyl)aniline;chloride exemplifies the complex interplay between structure and function in chemistry. Its multifaceted nature opens doors for further exploration in research and development.

Synonyms
ST 608
2-(2-Chloro-3-methylphenylamino)-2-imidazoline hydrochloride
16822-98-3
2-(2-Chloro-m-toluidino)-2-imidazoline HCl
1H-Imidazol-2-amine, 4,5-dihydro-N-(2-chloro-3-methylphenyl)-, monohydrochloride
2-IMIDAZOLINE, 2-(2-CHLORO-m-TOLUIDINO)-, MONOHYDROCHLORIDE
1H-Imidazol-2-amine, N-(2-chloro-3-methylphenyl)-4,5-dihydro-, monohydrochloride
1H-Imidazol-2-amine, N-(2-chloro-3-methylphenyl)-4,5-dihydro-, monohydrochloride (9CI)
1H-Imidazol-2-amine, 4,5-dihydro-N-(2-chloro-3-methylphenyl)-, monohydrochloride (9CI)