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Clonidine

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Identification
Molecular formula
C9H9Cl2N3
CAS number
4205-91-8
IUPAC name
2-chloro-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
State
State

At room temperature, clonidine is in a solid state. It is generally administered in the form of tablets or patches for medical use.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
405.20
Boiling point (Kelvin)
678.35
General information
Molecular weight
230.10g/mol
Molar mass
230.0960g/mol
Density
1.3000g/cm3
Appearence

Clonidine typically appears as a white or off-white crystalline powder. It does not have any characteristic odor. The powder form is commonly used in pharmaceutical preparations.

Comment on solubility

Solubility of 2-chloro-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline

The solubility of 2-chloro-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline can be influenced by several factors due to its unique structure. This compound is known to exhibit moderate solubility in organic solvents, while its solubility in water is generally limited.

Key factors affecting solubility include:

  • Polarity: The presence of both hydrophobic (aromatic rings) and hydrophilic (amino group) parts in the molecule affects its interaction with solvents.
  • Temperature: As with many compounds, increasing temperature often enhances solubility, potentially allowing for better dissolution in polar solvents like water.
  • pH of the solvent: The ionization of the amino group in acidic or basic conditions can significantly improve solubility.

In practical terms, this means that while 2-chloro-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline may dissolve adequately in organic solvents like dichloromethane or ethanol, one might encounter challenges when attempting to dissolve it in aqueous solutions. Thus, understanding its solubility characteristics is vital for its application in various chemical processes.

Interesting facts

Interesting Facts About 2-Chloro-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline

2-Chloro-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline is a fascinating compound that belongs to the class of substituted anilines. Its unique structure allows it to play significant roles in various chemical applications:

  • Pharmaceutical Intermediates: This compound serves as an important intermediate in the synthesis of various pharmaceuticals. Its ability to act as a building block for complex molecules is highly valued in medicinal chemistry.
  • Biological Activity: Compounds related to this structure have been studied for their biological activities, including potential antimicrobial and anti-cancer properties. The imidazole ring is known for its presence in several biologically active molecules.
  • Versatility in Reactions: As a chlorinated aniline, it is reactive towards nucleophilic substitution reactions, which further expands its utility in organic synthesis. Chemists often leverage this reactivity to develop new compounds.
  • Research Interest: The unique combination of the chlorinated aromatic system and the imidazole moiety draws significant interest from researchers exploring new synthetic methodologies and applications in materials science.

In summary, 2-chloro-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline stands out due to its reactivity, biological significance, and application in the pharmaceutical industry. Its study sheds light on the intricate relationships between molecular structure and function, making it a valuable subject of research for chemists and biologists alike.