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2-Chloro-4-methylsulfonyl aniline

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Identification
Molecular formula
C7H8ClNO2S
CAS number
5053-06-5
IUPAC name
2-chloro-4-methylsulfonyl-aniline
State
State

At room temperature, 2-Chloro-4-methylsulfonyl aniline is in a solid state. It remains stable under normal conditions and is commonly used in research and industrial applications in this form.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
358.00
Boiling point (Kelvin)
631.15
General information
Molecular weight
221.68g/mol
Molar mass
221.6830g/mol
Density
1.4300g/cm3
Appearence

2-Chloro-4-methylsulfonyl aniline is typically a crystalline solid with a white to off-white coloration. This compound may sometimes exhibit a faint odor typical of aromatic amines, but it is primarily characterized by its solid appearance at room temperature.

Comment on solubility

Solubility of 2-Chloro-4-methylsulfonyl-aniline

2-Chloro-4-methylsulfonyl-aniline, with the chemical formula C7H8ClNO2S, exhibits distinct solubility characteristics that are influenced by its functional groups and molecular structure. Understanding its solubility is crucial for applications in chemical synthesis and pharmaceutical formulation.

Solubility Characteristics:

  • Solvent Dependence: This compound is generally soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and ethanol, owing to its sulfonyl and amino groups which can interact favorably in these environments.
  • Water Solubility: The presence of the amino group suggests some potential for solubility in water; however, due to the bulkiness of the chloromethyl and sulfonyl groups, significant solubility in pure water is unlikely.
  • Temperature Influence: Solubility may increase with temperature, as is common with many organic compounds, enhancing the kinetic energy of molecules and facilitating interactions with solvent molecules.

As a general rule, the interaction of functional groups in a molecule will dictate its overall solubility behavior. In summary, while 2-chloro-4-methylsulfonyl-aniline shows promising solubility in certain organic solvents, its performance in water is limited, highlighting the importance of solvent selection in experimental applications.

Interesting facts

Interesting Facts about 2-chloro-4-methylsulfonyl-aniline

2-chloro-4-methylsulfonyl-aniline is a fascinating compound with numerous applications in the field of chemistry and medicinal research. Here are some intriguing facts:

  • Pharmaceutical Relevance: This compound, often utilized in the synthesis of pharmaceuticals, plays a critical role in developing various therapeutic agents.
  • Structural Significance: The presence of chlorine and the sulfonyl group on the aniline ring contributes to its unique reactivity, making it a valuable substrate for further chemical transformations.
  • Industrial Applications: Beyond its medicinal uses, 2-chloro-4-methylsulfonyl-aniline is employed in dye manufacturing and agricultural chemicals, showcasing its versatility in both chemical industries.
  • Synthesis Pathways: The synthetic routes to producing this compound are of great interest, often involving electrophilic aromatic substitution, which demonstrates fundamental principles of organic chemistry.
  • Toxicity Considerations: As with many chlorinated compounds, there are important safety and toxicity considerations surrounding 2-chloro-4-methylsulfonyl-aniline, emphasizing the need for proper handling and disposal in laboratory settings.

Quotes from notable chemists highlight its importance: "The study of novel compounds like 2-chloro-4-methylsulfonyl-aniline opens new avenues in drug discovery."

In summary, 2-chloro-4-methylsulfonyl-aniline is a compound that not only embodies the complexity of organic chemistry but also offers wide-ranging implications for pharmaceutical development and industrial applications.

Synonyms
2-Chloro-4-mesylaniline
4-Amino-3-chlorophenylmethylsulphone
Benzenamine, 2-chloro-4-(methylsulfonyl)-
BRN 2093959
1-Amino-2-chloro-4-methylsulfonylbenzene
4-Amino-3-chlorofenylomethylosulfon
4-Amino-3-chlorophenylmethylsulfone
EINECS 236-225-8
ANILINE, 2-CHLORO-4-(METHYLSULFONYL)-
4-Amino-3-chlorofenylomethylosulfon [Polish]
3-13-00-01327 (Beilstein Handbook Reference)
2-Chloro-4-(methylsulfonyl)benzenamine
236-225-8
2-Chloro-4-(methylsulfonyl)aniline
13244-35-4
2-chloro-4-methylsulfonylaniline
2-chloro-4-methylsulphonylaniline
MFCD00152349
3-Chloro-4-aminophenylmethylsulfone
4-Amino-3-chlorophenyl methyl sulfone
2-chloro-4-(methylsulfonyl)phenylamine
2-chloro-4-(methylsulphonyl)aniline
Benzenamine,2-chloro-4-(methylsulfonyl)-
SCHEMBL303829
2-chlor-4-methylsulfonylanilin
DTXSID4051669
2-chloro-4-methylsulfonyl aniline
2-chloro-4-(methanesulfonyl)aniline
2-chloro-4-(methylsulfonyl)-aniline
SBB003494
aniline, 2-chloro-4-methylsulphonyl-
AKOS015850117
FS-4558
BP-12646
SY062676
CS-0128075
NS00024215
ST45027462
F82694