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Clotiazepam

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Identification
Molecular formula
C21H23ClN2O
CAS number
33671-46-4
IUPAC name
2-chloro-5-[2-(1-piperidyl)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one
State
State

At room temperature, Clotiazepam is in a solid state. It is usually distributed in its solid form and can be processed into tablets or capsules for medical use, as it is commonly used in pharmacological settings.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
376.00
Boiling point (Kelvin)
649.15
General information
Molecular weight
353.88g/mol
Molar mass
353.8380g/mol
Density
1.4000g/cm3
Appearence

Clotiazepam typically appears as a crystalline powder. It is usually white or off-white in color, highlighting its purity when synthesized for pharmaceutical purposes. Due to its crystalline nature, it may exhibit some light-reflecting properties, but primarily maintains a matte finish.

Comment on solubility

Solubility of 2-chloro-5-[2-(1-piperidyl)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of the compound 2-chloro-5-[2-(1-piperidyl)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one can be influenced by various factors, including its molecular structure, intermolecular interactions, and the solvent used. Here are some key points regarding its solubility:

  • Polarity: The presence of the chlorine atom and piperidyl group introduces polarity in the molecule, which can enhance solubility in polar solvents.
  • Solvent Compatibility: This compound is likely to show better solubility in organic solvents such as ethanol, dichloromethane, or acetone rather than in water due to its structural characteristics.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds with solvents can greatly affect its solubility; if the solvent can adequately interact with the existing functional groups, solubility will be improved.
  • Temperature Influence: Increased temperature often enhances the solubility of organic compounds by increasing molecular motion; thus, evaluating solubility across a temperature range can provide more insights.

Overall, while general trends can be noted, definitive solubility values should be determined experimentally for precise applications, especially when considering different environmental conditions. As always, it is vital to conduct solubility tests under specified conditions to achieve accurate results.

Interesting facts

Discovering 2-chloro-5-[2-(1-piperidyl)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one

The compound 2-chloro-5-[2-(1-piperidyl)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one is a fascinating member of the benzodiazepine family, known for its pharmacological significance. Here are several intriguing facts about this compound:

  • Structural Complexity: This compound features a unique *benzo[b][1,4]benzodiazepine* scaffold, which contributes to its complex properties. The incorporation of both a *chloro* group and a *piperidyl* substituent adds to its structural diversity, potentially influencing its biological activity.
  • Potential Therapeutic Applications: Like other benzodiazepines, this compound may exhibit properties such as anxiolytic (anxiety-reducing), sedative, and muscle relaxant effects. Further studies could shed light on its potential use in treating conditions such as anxiety disorders or insomnia.
  • Action Mechanism: Benzodiazepines generally act by enhancing the effect of the neurotransmitter *gamma-aminobutyric acid (GABA)* at the GABAA receptor, leading to increased inhibitory neurotransmission. Understanding how our compound interacts with these receptors could elucidate its pharmacological profile.
  • Research Significance: The synthesis and study of such derivatives are critical in medicinal chemistry, offering pathways to developing more effective and selective therapeutic agents that minimize side effects typically associated with benzodiazepines.

In summary, 2-chloro-5-[2-(1-piperidyl)ethyl]-11H-benzo[b][1,4]benzodiazepin-6-one stands out for its intricate structure and potential applications in medicine. As with many compounds in its class, further exploration may unlock new insights into treatment strategies for various psychological conditions.

Synonyms
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-7-chloro-10-(2-(piperidino)ethyl)-
3910-26-7
BRN 0899979
10,11-Dihydro-11-oxo-5H-dibenzo(b,e)(1,4)diazepine, 7-chloro-10-(2-(piperidino)ethyl)-
DTXSID50192348