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Clonazepam

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Identification
Molecular formula
C15H10ClN3O3
CAS number
1622-61-3
IUPAC name
2-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one
State
State

Clonazepam is a solid at room temperature. It is usually found in the form of tablets for clinical and pharmaceutical applications.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.15
Boiling point (Celsius)
201.50
Boiling point (Kelvin)
474.65
General information
Molecular weight
353.79g/mol
Molar mass
353.7870g/mol
Density
1.3000g/cm3
Appearence

Clonazepam is a yellow crystalline powder. It is not very soluble in water but can dissolve in organic solvents such as ethanol and chloroform. The crystalline nature of the compound gives it an appearance typical of solid benzodiazepines.

Comment on solubility

Solubility of 2-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one

The solubility of 2-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one can be complex, influenced by several factors including molecular structure and the solvent used. Key considerations include:

  • Polarity: This compound contains a chloro group and a dimethylamino group, which can enhance its polarity. Polar compounds typically show better solubility in polar solvents.
  • Hydrogen bonding: The presence of amine groups may enable hydrogen bonding, potentially increasing solubility in water.
  • Solvent choice: Solubility may vary significantly in different solvents. For example, it may dissolve better in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol rather than in pure water.
  • Temperature effects: Increased temperature often enhances solubility, allowing for more effective interactions between solute and solvent.
  • Concentration: At higher concentrations, solubility limits may be observed, leading to precipitation or phase separation.

Generally speaking, “the solubility of a compound reflects its chemical nature and interactions with solvents,” making it crucial to consider these factors for practical applications in pharmaceuticals and chemical formulations.

In summary, while 2-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one may exhibit moderate solubility in certain conditions, its effective use in various contexts will depend heavily on the solvent system employed and specific experimental conditions.

Interesting facts

Interesting Facts about 2-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one

This compound belongs to the class of benzodiazepines, known for their significant impact in the field of medicinal chemistry.

Key Characteristics:

  • Pharmacological Properties: Benzodiazepines are well-known for their anxiolytic, sedative, hypnotic, muscle-relaxant, and anticonvulsant effects. This compound, in particular, demonstrates a unique profile that makes it of interest in pharmacological research.
  • Chemical Structure: The presence of both chlorine and dimethylamino groups enhances its activity and specificity, potentially influencing the drug-receptor interaction mechanisms.
  • Applications: This compound could be explored for applications in treating anxiety disorders, insomnia, and other neurological conditions.

Research and Development:

Significant ongoing research is being conducted to understand the efficacy and safety of benzodiazepine derivatives. The exploration of such compounds aids in the development of novel therapeutic agents, providing improved patient outcomes and reduced side effects.

Quote from Research:

As stated by a leading pharmacologist, "Understanding the intricate designs of benzodiazepines can unlock new avenues in developing safer and more effective medications."

In summary, 2-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one exemplifies the complex and fascinating world of medicinal chemistry and serves as a reminder of the potential of benzodiazepine compounds in therapeutic contexts.