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Diltiazem

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Identification
Molecular formula
C22H26ClN2O4S
CAS number
42399-41-7
IUPAC name
2-chloro-5-[2-(dimethylamino)ethyl]-11,11-dioxo-benzo[b][1,4]benzothiazepin-6-one
State
State

At room temperature, Diltiazem is in a solid state. It is a solid crystalline powder, which allows for its use in various pharmaceutical formulations.

Melting point (Celsius)
213.00
Melting point (Kelvin)
486.15
Boiling point (Celsius)
318.00
Boiling point (Kelvin)
591.15
General information
Molecular weight
414.97g/mol
Molar mass
414.9300g/mol
Density
1.5049g/cm3
Appearence

Diltiazem is a white to off-white crystalline powder with a bitter taste. It is odorless and typically appears as fine, divided particles. The crystalline structure of the compound contributes to its unique physical properties.

Comment on solubility

Solubility of 2-chloro-5-[2-(dimethylamino)ethyl]-11,11-dioxo-benzo[b][1,4]benzothiazepin-6-one

The solubility of 2-chloro-5-[2-(dimethylamino)ethyl]-11,11-dioxo-benzo[b][1,4]benzothiazepin-6-one can be influenced by various factors due to its complex structure. Understanding how this compound interacts with different solvents is essential for practical applications. Here are the key points regarding its solubility:

  • Polarity: The presence of dimethylamino and chlorine functionalities suggests some polar character, which may improve solubility in polar solvents like water or alcohols.
  • Hydrophobic Regions: The large aromatic system and the dioxo groups may limit solubility in non-polar solvents, despite having polar substituents.
  • pH Sensitivity: The ionization state of the compound can change with pH, potentially affecting solubility. For example, it may be more soluble in acidic conditions.
  • Temperature Effects: Increased temperature generally enhances solubility; thus, heating the solvent may be beneficial.
  • Concentration Dependencies: Solubility may decrease at higher concentrations, indicating potential saturation limits in solutions.

In conclusion, while this compound possesses features that indicate it may be soluble in certain polar solvents, factors such as pH, temperature, and the solvent's nature will ultimately govern its solubility. Proper experimentation is recommended to determine its exact solubility profile in various conditions.

Interesting facts

Interesting Facts about 2-Chloro-5-[2-(dimethylamino)ethyl]-11,11-dioxo-benzo[b][1,4]benzothiazepin-6-one

This compound belongs to the complex family of benzothiazepinones, which are known for their diverse biological activities and potential therapeutic applications. Benzothiazepines are notable for their multi-functional nature, often engaging in various interactions that make them valuable in medicinal chemistry.

Key Features:

  • Pharmacological Importance: Compounds in this class are frequently studied for their potential as calcium channel blockers, which can be instrumental in treating cardiovascular diseases.
  • Mechanism of Action: By modulating the influx of calcium ions, these compounds can help in regulating muscle contraction and vascular tone.
  • Potential as Antidepressants: Research has indicated that certain derivatives may exhibit antidepressant properties, presenting possibilities for new treatments in mental health.
  • Structural Diversity: The presence of the dimethylamino group enhances the compound's lipophilicity, possibly affecting its pharmacokinetic profile and overall efficacy.
  • Research Tool: This compound serves as a valuable scaffold for medicinal chemists aiming to design new derivatives with improved activity and selectivity.

In the realm of synthetic organic chemistry, the ability to manipulate the various functional groups in compounds like 2-chloro-5-[2-(dimethylamino)ethyl]-11,11-dioxo-benzo[b][1,4]benzothiazepin-6-one opens up avenues for customized drug development. The intricate synthesis and varying substitutions allow chemists to explore and optimize biological effects.

As we continue to unravel the potential of such compounds, it is evident that the interplay between structure and function is crucial. As one researcher aptly put it, "Understanding the nuances of chemical structure is key to unlocking therapeutic potential."

In conclusion, the exploration of this compound not only highlights the richness of benzothiazepine derivatives but also emphasizes the importance of continued research in discovering new medications that can better serve human health.

Synonyms
BRN 1226570
Dibenzo(b,f)(1,4)thiazepin-11-one, 10,11-dihydro-7-chloro-10-(2-(dimethylamino)ethyl)-S,S-dioxide
19190-30-8
DTXSID20172738
DTXCID8095229
RefChem:337125