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Clotiazepam

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Identification
Molecular formula
C16H16ClN3O
CAS number
33671-46-4
IUPAC name
2-chloro-5-[2-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one
State
State
Clotiazepam is typically a solid at room temperature, appearing as a crystalline powder. It is stable under normal conditions and does not volatilize easily.
Melting point (Celsius)
187.00
Melting point (Kelvin)
460.00
Boiling point (Celsius)
535.85
Boiling point (Kelvin)
809.00
General information
Molecular weight
353.77g/mol
Molar mass
353.8320g/mol
Density
1.3040g/cm3
Appearence

Clotiazepam is typically found as a crystalline solid. It may appear as a white or pale yellow powder, depending on purity and form. It is usually odorless and stable under normal conditions.

Comment on solubility

Solubility of 2-chloro-5-[2-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 2-chloro-5-[2-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one is an important consideration in its application and effectiveness. Typically, the solubility of such compounds can be influenced by several key factors:

  • Polarity: The presence of polar groups often enhances solubility in polar solvents like water.
  • Hydrophobicity: Conversely, hydrophobic parts of the molecule can lead to low solubility in aqueous environments.
  • Functional Groups: The dimethylamino and chloro functional groups play a significant role in solubility characteristics.

In general, it is common for compounds with a complex structure like this one to exhibit:

  • Low solubility in water, due to their large hydrophobic regions.
  • Increased solubility in organic solvents, such as ethanol or dimethyl sulfoxide (DMSO).

As a summary, understanding the solubility of this compound provides valuable insights for researchers and professionals, as it impacts parameters such as bioavailability and dosage formulation. As always, laboratory testing is recommended to obtain accurate solubility data which can guide further experimental or pharmaceutical use.

Interesting facts

Interesting Facts about 2-chloro-5-[2-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one

2-chloro-5-[2-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one is a fascinating member of the benzodiazepine family, which are clinically significant due to their psychoactive properties. Here are some intriguing aspects of this compound:

  • Mechanism of Action: Similar to other benzodiazepines, it is believed to enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor. This mechanism is crucial for its anxiolytic, sedative, and muscle relaxant properties.
  • Research Interest: Compounds like this one are often the focus of research to develop new medications, particularly for anxiety and sleep disorders. The structural modifications can lead to differing effects, making such research vital for therapeutic advancements.
  • Structural Features: The presence of both a chloro group and a dimethylamino side chain reflects the compound's complexity and can dictate its pharmacological profile. Structural diversity allows for tailored medicinal properties, contributing to its allure in medicinal chemistry.
  • Potential Side Effects: As with many benzodiazepines, understanding the side effects is crucial. Dependence and withdrawal symptoms can occur, emphasizing the importance of research on this compound in the context of safety and efficacy.
  • In the Lab: Synthetic routes to create this compound often involve multiple steps and careful control of reaction conditions, showcasing the challenges of organic synthesis and the skill required to produce high-purity products.

Overall, 2-chloro-5-[2-(dimethylamino)propyl]-11H-benzo[b][1,4]benzodiazepin-6-one exemplifies the intricate balance of chemistry, pharmacology, and therapeutic potential. As we delve into the world of chemical compounds, understanding such structures not only broadens our knowledge but also holds promise for future medical breakthroughs.

Synonyms
1163-08-2
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-7-chloro-10-(2-(dimethylamino-2-methyl)ethyl)-
BRN 0895123
DTXSID70921990
7-chloro-10-[2-(dimethylamino)propyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one