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Niflumic Acid

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Identification
Molecular formula
C13H8ClN3O4
CAS number
4394-00-7
IUPAC name
2-chloro-5-[[4-(3-nitrophenyl)-2,5-dioxo-pyrrol-3-yl]amino]benzoic acid
State
State

At room temperature, Niflumic Acid is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
202.00
Melting point (Kelvin)
475.15
Boiling point (Celsius)
748.00
Boiling point (Kelvin)
1 021.15
General information
Molecular weight
308.66g/mol
Molar mass
308.6610g/mol
Density
1.5624g/cm3
Appearence

Niflumic Acid appears as a yellow crystalline powder. The compound's crystalline nature gives it a distinct powdery texture.

Comment on solubility

Solubility of 2-chloro-5-[[4-(3-nitrophenyl)-2,5-dioxo-pyrrol-3-yl]amino]benzoic acid

The solubility of 2-chloro-5-[[4-(3-nitrophenyl)-2,5-dioxo-pyrrol-3-yl]amino]benzoic acid (C13H8ClN3O4) can be influenced by various factors, making it an interesting compound to study. Here are some key points regarding its solubility:

  • Polarity: The presence of both polar (–COOH, –Cl, –NO2) and non-polar (aromatic) groups in the compound affects its interaction with solvents.
  • Solvent Type: It may show different solubility behaviors in various solvents. For instance, it is likely to be more soluble in polar solvents like water or dimethyl sulfoxide (DMSO) due to hydrogen bonding with the carboxylic acid group, while being less soluble in non-polar solvents.
  • pH Dependency: The solubility of acids typically increases in higher pH environments (aqueous solutions) due to deprotonation, forming a conjugate base, which is usually more soluble.
  • Temperature Effects: These compounds often exhibit increased solubility at higher temperatures due to enhanced molecular motion and solvation processes.

In summary, predicting the solubility of this compound involves a careful consideration of its chemical structure and the environment in which it is placed. As noted, “solubility is a complex interplay of molecular interactions”, and for this compound, understanding these interactions is key to effectively assessing its solubility characteristics.

Interesting facts

Interesting Facts about 2-Chloro-5-[[4-(3-Nitrophenyl)-2,5-dioxo-pyrrol-3-yl]amino]benzoic Acid

This fascinating compound, 2-chloro-5-[[4-(3-nitrophenyl)-2,5-dioxo-pyrrol-3-yl]amino]benzoic acid, is notable for its diverse applications in the fields of medicinal chemistry and organic synthesis.

Key Features of the Compound

  • Unique Structure: The presence of both chlorine and nitro groups in its structure contributes to its chemical reactivity, leading to various possible derivatives that can be synthesized further.
  • Biological Activity: Many compounds containing the benzoic acid moiety exhibit biological activity, making this compound a potential candidate for drug development. Researchers are interested in its efficacy as an antimicrobial or anti-inflammatory agent.
  • Versatile Building Block: This compound can serve as a building block for creating more complex organic molecules, featuring in the synthesis of advanced materials or pharmaceuticals.

Applications

Its applications extend beyond pharmaceuticals as it is useful in:

  • Pesticide development: Compounds with similar structures have been investigated for their effectiveness in agricultural chemicals.
  • Coordination compounds: The presence of nitrogen within the structure opens routes to form coordination complexes with metals.

Research Implications

A major area of research focuses on modifying the compound's structure to enhance its biological properties. The intricate balance between its functional groups allows for:

  • Substituent Variation: Changing substituents can amplify or diminish certain properties.
  • Combinatorial Chemistry: The compound can be utilized in high-throughput screening to discover new therapeutic agents.

In summary, 2-chloro-5-[[4-(3-nitrophenyl)-2,5-dioxo-pyrrol-3-yl]amino]benzoic acid showcases a promising intersection of synthetic organic chemistry and medicinal applications. Its ability to inspire further research highlights the dynamic nature of organic compounds in the pursuit of novel discoveries.

Synonyms
CHEMBL156379
4-arylmaleimide deriv. 6bb
BDBM8271
BDBM50373079
2-chloro-5-{[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid