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Dichloramine-T

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Identification
Molecular formula
C9H13ClN2O3S
CAS number
127-65-1
IUPAC name
2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide
State
State

At room temperature, 2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide exists as a solid, which is characteristic of many small organic molecules with similar functional groups.

Melting point (Celsius)
226.00
Melting point (Kelvin)
499.15
Boiling point (Celsius)
760.00
Boiling point (Kelvin)
1 033.15
General information
Molecular weight
268.72g/mol
Molar mass
268.7230g/mol
Density
1.2180g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. It may have a slight odor depending on the purity and form in which it is available.

Comment on solubility

Solubility of 2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide

The solubility of 2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide is influenced by its structural features, which include a sulfonamide group and a chlorine substituent on a benzene ring. Here are some key points to consider regarding its solubility:

  • Polarity: The presence of polar functional groups, such as the sulfonamide, may enhance solubility in polar solvents like water.
  • Hydrogen bonding: The sulfonamide group can engage in hydrogen bonding, which may contribute to solubility, particularly in polar environments.
  • Non-polar characteristics: Despite its polar groups, the benzene ring introduces non-polar characteristics, possibly limiting solubility in strictly polar solvents.
  • Solvent dependency: Solubility can vary significantly with different solvents. It may be more soluble in organic solvents than in water.

In summary, while 2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide shows potential for solubility due to its polar groups, one must consider the balance between its polar and non-polar regions, which ultimately affects its solubility profile. Understanding these interactions is key to predicting its behavior in various chemical environments.

Interesting facts

Interesting Facts about 2-Chloro-5-(Dimethylaminocarbamoyl)benzenesulfonamide

2-Chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide, often referred to as a sulfonamide compound, presents a diverse range of applications and fascinating characteristics that are worth exploring. This compound is particularly notable in the realm of medicinal chemistry and drug development, where its unique structural components contribute to its biological activity.

Key Attributes

  • Pharmaceutical Relevance: Sulfonamides like this compound are significant as antibacterial agents. They work by inhibiting bacterial folic acid synthesis, a vital process for bacterial growth and replication.
  • Versatility: The presence of both chloro and dimethylamino groups allows for modifications that can enhance the compound's activity, making it a candidate for various pharmaceutical derivatives.
  • Targeting Mechanism: The specific configuration of the benzenesulfonamide group allows for selective interactions with bacterial enzymes, which can lead to potent drug formulations with minimal side effects.

As a scientist, one might wonder about the synthesis and modification potential of this compound. The ability to tweak the substituents on the benzene ring can lead to a vast library of analogs, which can be screened for antimicrobial efficacy. “Structure-activity relationship (SAR) studies are crucial in drug development,” says many a medicinal chemist. The exploration of such relationships is pivotal in understanding how modifications can enhance or diminish biological activity.

Research Potential

This compound is a valuable participant in ongoing research aimed at overcoming antibiotic resistance, a critical challenge in modern medicine. By investigating the interactions and stability of sulfonamide compounds, researchers hope to pave the way for new antimicrobial therapies that meet public health needs.

Overall, the study of 2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide and related compounds not only enriches our understanding of medicinal chemistry but also reinforces the importance of innovative approaches in tackling bacterial infections and antibiotic resistance.

Synonyms
ALIPAMIDE
3184-59-6
Alipamida
2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide
CI-546
CN-38,474
PE8925K9EY
Benzoic acid, 4-chloro-3-sulfamoyl-, 2,2-dimethylhydrazide
D-1721
4-Chloro-3-sulfamoylbenzoic acid 2,2-dimethylhydrazide
Alipamidum
CN-38474
Alipamid
Benzoic acid, 3-(aminosulfonyl)-4-chloro-2,2-dimethylhydrazide
UNII-PE8925K9EY
Alipamide [USAN:INN:BAN]
CI 546
CN 38474
ALIPAMIDE [INN]
Alipamide (USAN/INN)
ALIPAMIDE [USAN]
D 1721
4-Chlor-2,2'-dimethyl-3-sulfamoylbenzohydrazid
SCHEMBL120853
CHEMBL2106662
DTXSID40185704
AKOS040750321
NS00123772
D02813
Q27286504
2-chloro-5-[(2,2-dimethylhydrazino)carbonyl]benzenesulfonamide